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Chemistry: Recent submissions
Now showing items 401-420 of 964
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Some studies in the ternary system : copper formate-ammonium formate-formic acid
(University of Kansas, 1930) -
A study of the lyophilic nature of cellulose acetate in liquid ammonia
(University of Kansas, 1932) -
Assessing smectic liquid-crystal continuum models for elastic bilayer deformations
(Elsevier, 2014-04-01)For four decades, since W. Helfrich’s pioneering study of smectic A liquid crystals in 1973, continuum elastic models (CEMs) have been employed as tools to understand the energetics of protein-induced lipid bilayer ... -
Synthesis of epoxybenzo[d]isothiazole 1,1-dioxides via a reductive-Heck, metathesis-sequestration protocol
(Royal Society of Chemistry, 2012-09-07)An atom-economical purification protocol, using solution phase processing via ring-opening metathesis polymerization (ROMP) has been developed for the synthesis of tricyclic sultams. This chromatography-free method allows ... -
Metal-free transannulation reaction of indoles with nitrostyrenes: a simple practical synthesis of 3-substituted 2-quinolones
(Royal Society of Chemistry, 2016-07-15)3-Substituted 2-quinolones are obtained via a novel, metal-free transannulation reaction of 2-substituted indoles with 2-nitroalkenes in polyphosphoric acid. The reaction can be used in conjunction with the Fisher indole ... -
Intramolecular monomer-on-monomer (MoM) mitsunobu cyclization for the synthesis of benzofused thiadiazepine-dioxides
(Royal Society of Chemistry, 2012-06-14)The utilization of a monomer-on-monomer (MoM) intramolecular Mitsunobu cyclization reaction employing norbornenyl-tagged (Nb-tagged) reagents is reported for the synthesis of benzofused thiadiazepine-dioxides. Facile ... -
Reagent based DOS: A "Click, Click, Cyclize" strategy to probe chemical space
(Royal Society of Chemistry, 2010-05-07)The synthesis of small organic molecules as probes for discovering new therapeutic agents has been an important aspect of chemical-biology. Herein we report a reagent-based, diversity-oriented synthetic (DOS) strategy to ... -
One-pot synthesis of GABA amides via the nucleophilic addition of amines to 3, 3-disubtituted cyclopropenes
(Royal Society of Chemistry, 2015-09-14)A one-pot synthesis of various GABA amides has been demostrated, employing the nucleophilic addition of primary and secondary amines across the double bond of cyclopropene-3-carboxamides, followed by ring-opening of the ... -
Quantification of Reserve Pool Dopamine in Methionine Sulfoxide Reductase A Null Mice
(Elsevier, 2011-03-17)Methionine sulfoxide reductase A knockout (MsrA−/−) mice, which serve as a potential model for neurodegeneration, suffer from increased oxidative stress and have previously been found to have chronically elevated brain ... -
Impaired dopamine release and uptake in R6/1 Huntington's disease model mice
(Elsevier, 2011-03-29)Huntington’s disease (HD) is a progressive, neurodegenerative movement disorder. Here, we used fast-scan cyclic voltammetry to measure dopamine release and uptake in striatal brain slices from R6/1 HD model mice. Peak ... -
Single molecule probes of membrane structure: Orientation of BODIPY probes in DPPC as a function of probe structure
(Royal Society of Chemistry, 2013-03-21)Single molecule fluorescence measurements have recently been used to probe the orientation of fluorescent lipid analogs doped into lipid films at trace levels. Using defocused polarized total internal reflection fluorescence ... -
Microchip Electrophoresis with Amperometric Detection Method for Profiling Cellular Nitrosative Stress Markers
(Royal Society of Chemistry, 2015-07-07)The overproduction of nitric oxide (NO) in cells results in nitrosative stress due to the generation of highly reactive species such as peroxynitrite and N2O3. These species disrupt the cellular redox processes through the ... -
Software for Automated Interpretation of Mass Spectrometry Data from Glycans and Glycopeptides
(Royal Society of Chemistry, 2014-05-21)The purpose of this review is to provide those interested in glycosylation analysis with the most updated information on the availability of automated tools for MS characterization of N-linked and O-linked glycosylation ... -
Integration of Microsphere Resonators with Bioassay Fluidics for Whispering Gallery Mode Imaging
(Royal Society of Chemistry, 2014-06-07)Whispering gallery mode resonators are small, radially symmetric dielectrics that trap light through continuous total internal reflection. The resonant condition at which light is efficiently confined within the structure ... -
Development of an On-animal Separation-based Sensor for Monitoring Drug Metabolism in Freely Roaming Sheep
(Royal Society of Chemistry, 2016-06-07)The development of an on-animal separation-based sensor that can be employed for monitoring drug metabolism in a freely roaming sheep is described. The system consists of microdialysis sampling coupled directly to microchip ... -
Recent advances in the analysis of therapeutic proteins by capillary and microchip electrophoresis
(Royal Society of Chemistry, 2015-07-08)The development of therapeutic proteins and peptides is an expensive and time-intensive process. Biologics, which have become a multi-billion dollar industry, are chemically complex products that require constant observation ... -
Determination of Methylarginines in Infant Plasma by CE-LIF
(Royal Society of Chemistry, 2015-06-21)Methylarginines (MAs) are a class of nitric oxide synthase inhibitors that have been implicated in respiratory complications of critically ill infants. This paper describes the development of an analytical method to measure ... -
Biomimetic Peroxo- and Oxo-manganese Complexes: Insights into Structure and Reactivity through Kinetic, Spectroscopic, and Computational Studies
(University of Kansas, 2014-08-31)Manganese centers that react with O2 and its reduced derivatives mediate a diverse array of biologically important reactions including the detoxification of superoxide, the conversion of nucleotides to deoxynucleotides, ... -
Discovery and Evaluation of Catalytic Allylation and Amination Reactions
(University of Kansas, 2016-08-31)Presented herein is the development and evaluation of several palladium-catalyzed allylic alkylation reactions and a method for visible light-mediated radical decarboxylative amination. These atom economical, environmentally ... -
Progress in Developing a Clinically Viable Diagnostics Using Whispering Gallery Mode Resonators
(University of Kansas, 2016-08-31)Whispering gallery mode (WGM) resonators enable the label-free detection of analytes based on refractive index sensing. These WGM microsphere resonators achieve high sensitivities by confining light within their cavity. ...