Synthesis of epoxybenzo[d]isothiazole 1,1-dioxides via a reductive-Heck, metathesis-sequestration protocol

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Issue Date
2012-09-07Author
Asad, Naeem
Hanson, Paul R.
Long, Toby R.
Rayabarapu, Dinesh Kumar
Rolfe, Alan
Publisher
Royal Society of Chemistry
Type
Article
Article Version
Scholarly/refereed, author accepted manuscript
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Show full item recordAbstract
An atom-economical purification protocol, using solution phase processing via ring-opening metathesis polymerization (ROMP) has been developed for the synthesis of tricyclic sultams. This chromatography-free method allows for convenient isolation of reductive-Heck products and reclamation of excess starting material via sequestration involving metathesis catalysts and a catalyst-armed Si-surface.
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Citation
Asad, Naeem, Paul R. Hanson, Toby R. Long, Dinesh K. Rayabarapu, and Alan Rolfe. "Synthesis of Epoxybenzo[d]isothiazole 1,1-dioxides via a Reductive-Heck, Metathesis-sequestration Protocol." Chemical Communications 47.33 (2011): 9528.
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