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Chemistry: Recent submissions
Now showing items 381-400 of 964
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Reaction Pairing: A Diversity-Oriented Synthesis Strategy for the Synthesis of Diverse Benzofused Sultams
(American Chemical Society, 2011-10-07)A reaction pairing strategy centered on utilization of a reaction triad (sulfonylation, SNAr addition and Mitsunobu alkylation) generating skeletally diverse benzofused tricyclic and bicyclic sultams is reported. Pairing ... -
Structural basis for activation of calcineurin by calmodulin
(Elsevier, 2011-11-12)The highly conserved phosphatase calcineurin plays vital roles in numerous processes including T-cell activation, development and function of the central nervous system, and cardiac growth. It is activated by the calcium ... -
Rapid, Scalable Assembly of Stereochemically Rich, Mono- and Bicyclic Acyl Sultams
(American Chemical Society, 2014-01-03)A one-pot, sequential protocol is reported that involves complementary ambiphile pairing (CAP) of a vinyl sulfonamide with a variety of unprotected amino acids via aza-Michael addition and subsequent intramolecular amidation. ... -
Rapid decarboxylative allylation of nitroalkanes
(American Chemical Society, 2010-02-19)Allyl nitroacetates undergo decarboxylative allylation to provide tertiary nitroalkanes in high yield. Moreover, the transformations are complete within several minutes under ambient conditions. High yields result because ... -
Palladium-catalyzed Transformations of Salvinorin A, a Neoclerodane Diterpene from Salvia divinorum
(American Chemical Society, 2013-12-06)Transformations that selectively modify the furan ring present in a variety of naturals products would be useful in the synthesis of biological probes but remain largely underexplored. The neoclerodane diterpene salvinorin ... -
Monomer-on-Monomer (MoM) Mitsunobu Reaction: Facile Purification Utilizing Surface-Initiated Sequestration
(American Chemical Society, 2011-01-07)A monomer-on-monomer (MoM) Mitsunobu reaction utilizing norbornenyl-tagged (Nb-tagged) reagents is reported, whereby purification was rapidly achieved by employing ring-opening metathesis polymerization which is initiated ... -
Mild Decarboxylative Allylation of Coumarins
(American Chemical Society, 2009-08-06)Allyl esters of 3-carboxylcoumarins undergo facile decarboxylative coupling at just 25–50 °C. This represents the first extension of decarboxylative C–C bond-forming reactions to the coupling of aromatics with sp3-hybridized ... -
Mechanistic origin of the stereodivergence in decarboxylative allylation
(American Chemical Society, 2010-07-02)A stereochemical test has been used to probe the mechanism of decarboxylative allylation. This probe suggests that the mechanism of DcA reactions can change based on the substitution pattern at the α-carbon of the nucleophile, ... -
Ligand-controlled Regioselective Cu-Catalyzed Trifluoromethylation to Generate Trifluoromethylallenes
(American Chemical Society, 2015-05-17)“Cu–CF3” species have been used historically for a broad spectrum of nucleophilic trifluoromethylation reactions. Although recent advancements have employed ligands to stabilize and harness the reactivity of this key ... -
High-Load, Hybrid Si-ROMP Reagents
(American Chemical Society, 2011-01-07)The combination of norbornenyl-tagged (Nb-tagged) silica particles and functionalized Nb-tagged monomers for the generation of hybrid Si-ROMP reagents and scavengers is reported. Specifically Si-ROMP-derived bis-acid ... -
Formal [4+3] Epoxide Cascade Reaction via a Complementary Ambiphilic Pairing Strategy
(American Chemical Society, 2010-03-19)A formal [4+3] epoxide cascade protocol utilizing ambiphilic sulfonamides and a variety of epoxides (masked ambiphiles) has been developed for the generation of benzothiaoxazepine-1,1′-dioxides and oxathiazepine-1,1′-dioxides. ... -
Microsphere-Based Scaffolds Encapsulating Tricalcium Phosphate And Hydroxyapatite For Bone Regeneration
(Springer Verlag, 2016-07-27)Bioceramic mixtures of tricalcium phosphate (TCP) and hydroxyapatite (HAp) are widely used for bone regeneration because of their excellent cytocompatibility, osteoconduction, and osteoinduction. Therefore, we hypothesized ... -
Engineered Chimeric Peptides as Antimicrobial Surface Coating Agents toward Infection-Free Implants
(American Chemical Society, 2016-03-02)Prevention of bacterial colonization and consequent biofilm formation remains a major challenge in implantable medical devices. Implant-associated infections are not only a major cause of implant failures but also their ... -
Label-free, in-solution screening of peptide libraries for binding to protein targets using hydrogen exchange-mass spectrometry (HX-MS)
(American Chemical Society, 2016-02-03)There is considerable interest in the discovery of peptide ligands that bind to protein targets. Discovery of such ligands is usually approached by screening large peptide libraries. However, the individual peptides must ... -
An Efficient, Modular Approach for the Synthesis of (+)-Strictifolione and a Related Natural Product
(American Chemical Society, 2014-01-03)An efficient, library amenable, “pot economical” total synthesis of (+)-strictifolione and the related natural product, (6R)-6[(E,4R,6R)-4,6-dihydroxy-10-phenyl-1-decenyl]-5,6-dihydro-2H-2-pyrone are reported. This modular ... -
A Phosphate Tether-Mediated, One-pot, Sequential RCM/CM/Chemo-selective Hydrogenation Protocol
(American Chemical Society, 2012-05-18)A versatile three-step, one-pot, sequential reaction protocol involving RCM, CM, and chemoselective hydrogenation is reported. This phosphate tether-mediated process occurs without intermediate isolation, is chemoselective ... -
A Formal [4+4] Complementary Ambiphile Pairing (CAP) Reaction: A New Cyclization Pathway for ortho-Quinone Methides
(American Chemical Society, 2010-03-21)A formal, one-pot, [4+4] cyclization pathway for the generation of 8-member sultams via in-situ generation of an ortho-quinone methide (o-QM) is reported. The pairing of ambiphilic synthons in a complementary fashion is ... -
A Concise, Phosphate-Mediated Approach to the Total Synthesis of (−)-Tetrahydrolipstatin
(American Chemical Society, 2010-04)An efficient synthesis of (−)-tetrahydrolipstatin (THL) is reported. This method takes advantage of a phosphate tether-mediated, one-pot, sequential RCM/CM/hydrogenation protocol to deliver THL in 8 total steps from a ... -
“Click”-Capture, ROMP, Release: Facile Triazolation Utilizing ROMP-derived Oligomeric Phosphates
(American Chemical Society, 2011-04-15)Soluble, high-load ROMP-derived oligomeric triazole phosphates (OTP) are reported for application as efficient triazolating reagents of nucleophilic species. Utilizing a “Click”-capture, ROMP, release protocol, the efficient ...