Intramolecular monomer-on-monomer (MoM) mitsunobu cyclization for the synthesis of benzofused thiadiazepine-dioxides

Maity, Pradip K.; Kainz, Quirin M.; Faisal, Saqib; Rolfe, Alan; Samarakoon, Thiwanka Bandara; Basha, Fatima Z.; Reiser, Oliver; Hanson, Paul R.

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Issue Date

2012-06-14

Author

Maity, Pradip K.

Kainz, Quirin M.

Faisal, Saqib

Rolfe, Alan

Samarakoon, Thiwanka Bandara

Basha, Fatima Z.

Reiser, Oliver

Hanson, Paul R.

Publisher

Royal Society of Chemistry

Type

Article

Article Version

Scholarly/refereed, author accepted manuscript

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Abstract

The utilization of a monomer-on-monomer (MoM) intramolecular Mitsunobu cyclization reaction employing norbornenyl-tagged (Nb-tagged) reagents is reported for the synthesis of benzofused thiadiazepine-dioxides. Facile purification was achieved via ring-opening metathesis (ROM) polymerization initiated by one of three metathesis catalyst methods: (i) free metathesis catalyst, (ii) surface-initiated catalyst-armed silica, or (iii) surface-initiated catalyst-armed Co/C magnetic nanoparticles.

Citation

Maity, Pradip K., Quirin M. Kainz, Saqib Faisal, Alan Rolfe, Thiwanka. B. Samarakoon, Fatima Z. Basha, Oliver Reiser, and Paul R. Hanson. "Intramolecular Monomer-on-monomer (MoM) Mitsunobu Cyclization for the Synthesis of Benzofused Thiadiazepine-dioxides." Chemical Communications 47.46 (2011): 12524.

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