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    Biomimetic Peroxo- and Oxo-manganese Complexes: Insights into Structure and Reactivity through Kinetic, Spectroscopic, and Computational Studies

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    Leto_ku_0099D_13532_DATA_1.pdf (9.352Mb)
    Issue Date
    2014-08-31
    Author
    Leto, Domenick F.
    Publisher
    University of Kansas
    Format
    296 pages
    Type
    Dissertation
    Degree Level
    Ph.D.
    Discipline
    Chemistry
    Rights
    Copyright held by the author.
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    Abstract
    Manganese centers that react with O2 and its reduced derivatives mediate a diverse array of biologically important reactions including the detoxification of superoxide, the conversion of nucleotides to deoxynucleotides, and the generation of O2 from H2O. Peroxo-, oxo-, and hydroxo-manganese motifs are frequently invoked in the catalytic cycles of Mn enzymes. To that end, biomimetic complexes featuring peroxo-, oxo-, and hydroxo-manganese adducts were synthesized and studied using spectroscopic techniques, including variable-temperature electronic absorption, electron paramagnetic resonance (EPR), X-ray absorption (XAS), and magnetic circular dichroism (MCD) spectroscopies along with computational methods, such as density functional theory (DFT) and time-dependent DFT. The structural and spectroscopic properties of these species were investigated in order to better understand how the geometric and electronic structure of these complexes affects reactivity.
    URI
    http://hdl.handle.net/1808/22548
    Collections
    • Chemistry Dissertations and Theses [336]
    • Dissertations [4472]

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    KU Libraries
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    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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