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Chemistry: Recent submissions
Now showing items 421-440 of 964
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Organic Leachates from Water Service Line Liners and Coatings and Their Fate in Drinking Water
(University of Kansas, 2015-05-31)There is growing interest in using pipe lining and coating technologies to control corrosion and prevent release of metals (lead and copper) into drinking water from water service lines and from water pipes in homes, ... -
Synthesis of an Isoindoline-Annulated, Tricyclic Sultam Library via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS)
(Thieme Publishing, 2012-07-04)A microwave-assisted, continuous-flow organic synthesis (MACOS) protocol for the synthesis of an isoindoline-annulated, tricyclic sultam library, utilizing a Heck–aza-Michael (HaM) strategy, is reported. This sequence ... -
Application of a Double Aza-Michael Reaction in a ‘Click, Click, Cy-Click’ Strategy: From Bench to Flow
(Thieme Publishing, 2011-03-18)The development of a ‘click, click, cy-click’ process utilizing a double aza-Michael reaction to generate functionalized 1,2,5-thiadiazepane 1,1-dioxides is reported. Optimization in flow, followed by scale out of the ... -
Synthesis of Chiral Nonracemic Tertiary α-Thio and α-Sulfonyl Acetic Esters via SN2 Reactions of Tertiary Mesylates
(Thieme Publishing, 2009-09-08)Syntheses of enantioenriched sulfides and sulfones via substitution of tertiary mesylate with thiolate nucleophile were achieved with modest to excellent success. -
Catalytic Intermolecular Hydroamination of Vinyl Ethers
(Thieme Publishing, 2009-07-30)This manuscript details the development of a palladium-catalyzed hydroamination of vinyl ethers. It is proposed that palladium catalyzes the hydroamination via Brønsted base catalysis, where palladium is protonated by the ... -
Energy-Related Applications of Molecular Simulations
(University of Kansas, 2016-08-31)We employ molecular simulations to investigate two key issues pertinent to sustainable energy: reducing emissions of CO2 into the atmosphere and the use of renewable energy sources. Specifically, we use Monte Carlo simulations ... -
Conformational Analysis of Intrinsically Disordered Proteins Using Mass Spectrometry-Based Approaches
(University of Kansas, 2016-08-31)Intrinsically disordered proteins (IDPs) have regions that are highly flexible and lack stable secondary or tertiary structure. Recently, there has been a growing interest in IDPs due to their important roles in many ... -
Characterization of Matrix Metalloproteinase-8 (MMP-8) Structure and Stability and the Effects of Its Interaction with the Inhibitory Metal Abstraction Peptide NCC Using High-Resolution Solution NMR
(University of Kansas, 2016-08-31)Matrix metalloproteinases (MMPs) are important enzymes for extracellular matrix degradation. Cleavage of collagen by MMP-8 is an important regulator of tissue remodeling in wound healing and repair, but it also contributes ... -
Solute location in a nanoconfined liquid depends on charge distribution
(AIP Publishing, 2015-07)Nanostructured materials that can confine liquids have attracted increasing attention for their diverse properties and potential applications. Yet, significant gaps remain in our fundamental understanding of such nanoconfined ... -
A graph-theoretical representation of multiphoton resonance processes in superconducting quantum circuits
(Nature Publishing Group, 2016-11-21)We propose a graph-theoretical formalism to study generic circuit quantum electrodynamics systems consisting of a two level qubit coupled with a single-mode resonator in arbitrary coupling strength regimes beyond rotating-wave ... -
Unravelling the dynamical origin of below- and near-threshold harmonic generation of H2+ in an intense NIR laser field
(Nature Publishing Group, 2016-11-24)Recently, the study of near- and below- threshold regime harmonics as a potential source of intense coherent vacuum-ultraviolet radiation has received considerable attention. However, the dynamical origin of these lower ... -
Studies on ethyl benzene and some new derivatives of diphenyl
(University of Kansas, 1930) -
Native Conformation and Canonical Disulfide Bond Formation Are Interlinked Properties of HIV-1 Env Glycoproteins
(Science Publications, 2016-03)We investigated whether there is any association between a native-like conformation and the presence of only the canonical (i.e., native) disulfide bonds in the gp120 subunits of a soluble recombinant human immunodeficiency ... -
Influences on the Design and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers
(Science Publications, 2015-08-26)We have investigated factors that influence the production of native-like soluble, recombinant trimers based on the env genes of two isolates of human immunodeficiency virus type 1 (HIV-1), specifically 92UG037.8 (clade ... -
Comparative Analysis of the Glycosylation Profiles of Membrane-Anchored HIV-1 Envelope Glycoprotein Trimers and Soluble gp140
(Science Publications, 2015-05-27)The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer, which consists of the gp120 and gp41 subunits, is the focus of multiple strategies for vaccine development. Extensive Env glycosylation ... -
Recent advances in the discovery and design of multicomponent reactions for the generation of small-molecule libraries
(Dove Medical Press, 2015-09-04)The current drug discovery process is dependent on the ability of synthetic chemistry to deliver libraries of small molecules with ever increasing levels of structural complexity and diversity. Sequencing multicomponent ... -
Synthesis and Applications of Amide-Based Pd(II) NNN-pincer Complexes
(University of Kansas, 2016-05-31)The first project is described in Chapter 2, and details the synthesis of a series of mono- and multimetallic Pd(II) NNN-pincer complexes which—to the best of our knowledge—represent the first examples of these types of ... -
Increasing the Understanding of Chemical Concepts: The Effectiveness of Multiple Exposures
(University of Kansas, 2016-05-31)Chemistry is difficult because it has multilevels of knowledge with each level presenting challenges in vocabulary, abstract thinking, and symbolic language. Students have to be able to transfer between levels to understand ... -
Development of a Separation-Based Sensor using Microdialysis Coupled to Microchip Electrophoresis with Electrochemical Detection for Monitoring Catecholamines
(University of Kansas, 2015-12-31)Microdialysis is a powerful separation technique capable of simultaneously monitoring multiple analytes in the extracellular fluid of the brain. This technique generates small sample volumes in a continuous flow stream. ... -
New Methods for Palladium-catalyzed Decarboxylative Benzylation, Arylation and Dearomatization Reactions
(University of Kansas, 2015-12-31)Development of novel synthetic methods for the efficient generation of new carbon-carbon bonds is a valuable endeavor in organic synthesis. In this regard, palladium-catalyzed decarboxylative cross-coupling has significant ...