Chemistry
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Experimental and Theoretical Study of Resonance Raman Spectroscopy in Ground and Excited Electronic States
(University of Kansas, 2019-12-31)Spectroscopy is a powerful tool for the identification, study, and selective control of molecular processes. Raman scattering is particularly useful in observing the vibrational properties of molecules, and identifying ... -
Dynamic elements and kinetics: Most favorable conformations of peptides in solution with measurements and simulations
(American Institute of Physics, 2019-12-12)Small peptides in solution adopt a specific morphology as they function. It is of fundamental interest to examine the structural properties of these small biomolecules in solution and observe how they transition from one ... -
Kinetic pathway analysis of an α-helix in two protonation states: Direct observation and optimal dimensionality reduction
(American Institute of Physics, 2019-02-21)Thermodynamically stable conformers of secondary structural elements make a stable tertiary/quaternary structure that performs its proper biological function efficiently. Formation mechanisms of secondary and tertiary/quaternary ... -
Electrophilically activated nitroalkanes in reaction with aliphatic diamines en route to imidazolines
(Royal Society of Chemistry, 2019-11-29)A novel synthetic methodology for the assembly of imidazolines via an unusual reaction between nitroalkanes and aliphatic 1,2-diamines in the presence of phosphorous acid is described. In contrast to the related highly ... -
Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles
(Royal Society of Chemistry, 2019-02-26)A novel methodology for general and chemoselective preparation of non-symmetric 1,3,4-oxadiazoles is developed. This unusual reaction proceeds via polyphosphoric acid-assisted activation of nitroalkanes towards nucleophilic ... -
Anion Relay Cyclopropanation and Aryl Vinyl Cyclopropane Cope Rearrangements
(University of Kansas, 2019-08-31)Anion Relay Chemistry is a powerful tool for the rapid development of molecular complexity in an operationally simple manner. Much of the work in this field has been pioneered and developed by the Smith group, whose work ... -
Molecular Simulation of the Passive Permeation of Small Peptides across Lipid Bilayers
(University of Kansas, 2019-08-31)The passive permeation of small peptides across lipid bilayers was studied by using molecular dynamics simulations and umbrella sampling. The knowledge gained in this work furthers our understanding of permeation across ... -
Genetic and Chemical Intervention of the BfrB:Bfd Interaction Dysregulate Iron Homeostasis in Pseudomonas aeruginosa and Affect its Broader Metabolism
(University of Kansas, 2020-05-31)Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that is accountable for multiple types of infections, including pneumonia, wound, burn, and urinary tract infections. P. aeruginosa is an emerging threat in ... -
Stabilization of the V2 loop improves the presentation of V2 loop–associated broadly neutralizing antibody epitopes on HIV-1 envelope trimers
(American Society for Biochemistry and Molecular Biology, 2019-04-05)A successful HIV-1 vaccine will likely need to elicit broadly neutralizing antibodies (bNAbs) that target the envelope glycoprotein (Env) spike on the virus. Native-like recombinant Env trimers of the SOSIP design now serve ... -
Multiplexed immunophenotyping of circulating exosomes on nano-engineered ExoProfile chip towards early diagnosis of cancer
(Royal Society of Chemistry, 2019-04-22)Circulating exosomes have been studied as a promising biomarker for non-invasive cancer diagnosis, as they are implicated in tumor initiation, progression, and metastasis. However, the clinical significance of circulating ... -
Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1
(MDPI, 2019-01-17)Carnosine (β-alanyl-L-histidine), a dipeptide, is an endogenous antioxidant widely distributed in excitable tissues like muscles and the brain. Carnosine is involved in cellular defense mechanisms against oxidative stress, ... -
Carnosine Decreases PMA-Induced Oxidative Stress and Inflammation in Murine Macrophages
(MDPI, 2019-08-06)Carnosine is an endogenous dipeptide composed of β-alanine and L-histidine. This naturally occurring molecule is present at high concentrations in several mammalian excitable tissues such as muscles and brain, while it can ... -
Single-Electron Redox Chemistry on the [Cp*Rh] Platform Enabled by a Nitrated Bipyridyl Ligand
(MDPI, 2018-11-02)[Cp*Rh] complexes (Cp* = pentamethylcyclopentadienyl) are attracting renewed interest in coordination chemistry and catalysis, but these useful compounds often undergo net two-electron redox cycling that precludes observation ... -
Sub-Toxic Human Amylin Fragment Concentrations Promote the Survival and Proliferation of SH-SY5Y Cells via the Release of VEGF and HspB5 from Endothelial RBE4 Cells
(MDPI, 2018-11-20)Human amylin is a 37-residue peptide hormone (hA1-37) secreted by β-cells of the pancreas and, along with insulin, is directly associated with type 2 diabetes mellitus (T2DM). Amyloid deposits within the islets of the ... -
Impact of Tryptophan Oxidation in Complementarity-Determining Regions of Two Monoclonal Antibodies on Structure-Function Characterized by Hydrogen-Deuterium Exchange Mass Spectrometry and Surface Plasmon Resonance
(Springer, 2018-12-10)Purpose Tryptophan’s (Trp) unique hydrophobic and structural properties make it an important antigen binding motif when positioned in complementarity-determining regions (CDRs) of monoclonal antibodies (mAbs). Oxidation ... -
A Collection of Single-Domain Antibodies that Crowd Ricin Toxin’s Active Site
(MDPI, 2018-12-17)In this report, we used hydrogen exchange-mass spectrometry (HX-MS) to identify the epitopes recognized by 21 single-domain camelid antibodies (VHHs) directed against the ribosome-inactivating subunit (RTA) of ricin toxin, ... -
Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1
(MDPI, 2019-01-17)Carnosine (β-alanyl-L-histidine), a dipeptide, is an endogenous antioxidant widely distributed in excitable tissues like muscles and the brain. Carnosine is involved in cellular defense mechanisms against oxidative stress, ... -
Stabilization of the V2 loop improves the presentation of V2 loop–associated broadly neutralizing antibody epitopes on HIV-1 envelope trimers
(American Society for Biochemistry and Molecular Biology, 2019-02-06)A successful HIV-1 vaccine will likely need to elicit broadly neutralizing antibodies (bNAbs) that target the envelope glycoprotein (Env) spike on the virus. Native-like recombinant Env trimers of the SOSIP design now serve ... -
Multiplexed immunophenotyping of circulating exosomes on nano-engineered ExoProfile chip towards early diagnosis of cancer
(Royal Society of Chemistry, 2019-04-22)Circulating exosomes have been studied as a promising biomarker for non-invasive cancer diagnosis, as they are implicated in tumor initiation, progression, and metastasis. However, the clinical significance of circulating ... -
Microfluidics as a Novel Tool for Biological and Toxicological Assays in Drug Discovery Processes: Focus on Microchip Electrophoresis
(MDPI, 2020-06-15)The last decades of biological, toxicological, and pharmacological research have deeply changed the way researchers select the most appropriate ‘pre-clinical model’. The absence of relevant animal models for many human ...
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