Chemistry
Browse by
Collections in this community
Recent Submissions
-
Integrating single-molecule FRET and biomolecular simulations to study diverse interactions between nucleic acids and proteins
(Portland Press, 2021-04-16)The conformations of biological macromolecules are intimately related to their cellular functions. Conveniently, the well-characterized dipole–dipole distance-dependence of Förster resonance energy transfer (FRET) makes ... -
Mobilization of Iron Stored in Bacterioferritin Is Required for Metabolic Homeostasis in Pseudomonas aeruginosa
(MDPI, 2020-11-24)Iron homeostasis offers a significant bacterial vulnerability because pathogens obtain essential iron from their mammalian hosts, but host-defenses maintain vanishingly low levels of free iron. Although pathogens have ... -
Synthesis of imidazo[1,5-a]pyridines via cyclocondensation of 2-(aminomethyl)pyridines with electrophilically activated nitroalkanes
(Beilstein-Institut, 2020-11-26)Imidazo[1,5-a]pyridines were efficiently prepared via the cyclization of 2-picolylamines with nitroalkanes electrophilically activated in the presence of phosphorous acid in polyphosphoric acid (PPA) medium. -
Tuning π-Acceptor/σ-Donor Ratio of the 2-Isocyanoazulene Ligand: Non-Fluorinated Rival of Pentafluorophenyl Isocyanide and Trifluorovinyl Isocyanide Discovered
(MDPI, 2021-02-12)Isocyanoazulenes (CNAz) constitute a relatively new class of isocyanoarenes that offers rich structural and electronic diversification of the organic isocyanide ligand platform. This article considers a series of ... -
Fc galactosylation follows consecutive reaction kinetics and enhances immunoglobulin G hexamerization for complement activation
(Taylor & Francis Open Access, 2021-03-08)Fc galactosylation is a critical quality attribute for anti-tumor recombinant immunoglobulin G (IgG)-based monoclonal antibody (mAb) therapeutics with complement-dependent cytotoxicity (CDC) as the mechanism of action. ... -
Dataset of why inclusion matters for Alzheimer's disease biomarker discovery in plasma
(Elsevier, 2021-04)Here we present a plasma proteomics dataset that was generated to understand the importance of self-reported race for biomarker discovery in Alzheimer's disease. This dataset is related to the article “Why inclusion matters ... -
Solid-phase XRN1 reactions for RNA cleavage: application in single-molecule sequencing
(Oxford University Press, 2021-01-28)Modifications in RNA are numerous (∼170) and in higher numbers compared to DNA (∼5) making the ability to sequence an RNA molecule to identify these modifications highly tenuous using next generation sequencing (NGS). The ... -
Organophotoredox/palladium dual catalytic decarboxylative Csp3–Csp3 coupling of carboxylic acids and π-electrophiles
(Royal Society of Chemistry, 2020-07-16)A dual catalytic decarboxylative allylation and benzylation method for the construction of new C(sp3)–C(sp3) bonds between readily available carboxylic acids and functionally diverse carbonate electrophiles has been ... -
Spatial confinement alters the ultrafast photoisomerization dynamics of azobenzenes
(Royal Society of Chemistry, 2020-08-24)Ultrafast transient absorption spectroscopy reveals new excited-state dynamics following excitation of trans-azobenzene (t-Az) and several alkyl-substituted t-Az derivatives encapsulated in a water-soluble supramolecular ... -
Length Dependent Folding Kinetics of Alanine-Based Helical Peptides from Optimal Dimensionality Reduction
(MDPI, 2021-04-24)We present a computer simulation study of helix folding in alanine homopeptides (ALA)n of length n = 5, 8, 15, and 21 residues. Based on multi-microsecond molecular dynamics simulations at room temperature, we found helix ... -
Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines
(MDPI, 2021-07-14)Nitroalkanes activated with polyphosphoric acid serve as efficient electrophiles in reactions with various nucleophilic amines. Strategically placed second functionality allows for the design of annulation reactions enabling ... -
Emerging Approaches to Understanding Microvascular Endothelial Heterogeneity: A Roadmap for Developing Anti-Inflammatory Therapeutics
(MDPI, 2021-07-21)The endothelium is the inner layer of all blood vessels and it regulates hemostasis. It also plays an active role in the regulation of the systemic inflammatory response. Systemic inflammatory disease often results in ... -
The Combination of Cigarette Smoking and Alcohol Consumption Synergistically Increases Reactive Carbonyl Species in Human Male Plasma
(MDPI, 2021-08-22)Cigarette smoking and alcohol consumption are major risk factors for lifestyle-related diseases. Although it has been reported that the combination of these habits worsens risks, the underlying mechanism remains elusive. ... -
Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-a]quinolines and 1,3,4-Oxadiazole Rings
(MDPI, 2021-09-20)Nitroalkanes activated with polyphosphoric acid could serve as efficient electrophiles in reactions with amines and hydrazines, enabling various cascade transformations toward heterocyclic systems. This strategy was developed ... -
Examining the Hofmeister Series through Activation Energies: Water Diffusion in Aqueous Alkali-Halide Solutions
(American Chemical Society, 2021-01-14)The effect of ions on the properties of aqueous solutions is often categorized in terms of the Hofmeister series that ranks them from chaotropes (“structure-breakers”), which weaken the surrounding hydrogen-bond network ... -
On the role of hydrogen-bond exchanges in the spectral diffusion of water
(2021-02-08)The dynamics ofa vibrational frequency in a condensed phase environment, i.e., the spectral diffusion, has attracted considerable interest over the last two decades. A significant impetus has been the development of ... -
Linear and Differential Ion Mobility Separations of Middle-Down Proteoforms
(American Chemical Society, 2018-01-23)Comprehensive characterization of proteomes comprising the same proteins with distinct post-translational modifications (PTMs) is a staggering challenge. Many such proteoforms are isomers (localization variants) that require ... -
Microfluidic-based solid phase extraction of cell free DNA
(Royal Society of Chemistry, 2018-10-04)Cell-free DNA (cfDNA) is a liquid biopsy marker that can carry signatures (i.e., mutations) associated with certain pathological conditions. Therefore, the extraction of cfDNA from a variety of clinical samples can be an ... -
Two New Tools for Glycopeptide Analysis Researchers: A Glycopeptide Decoy Generator and a Large Data Set of Assigned CID Spectra of Glycopeptides
(American Chemical Society, 2017-07-10)The glycopeptide analysis field is tightly constrained by a lack of effective tools that translate mass spectrometry data into meaningful chemical information, and perhaps the most challenging aspect of building effective ... -
Correction: Directed nucleophilic addition of phenoxides to cyclopropenes
(Royal Society of Chemistry, 2018-07-30)Correction for ‘Directed nucleophilic addition of phenoxides to cyclopropenes’ by Pavel Yamanushkin et al., Org. Biomol. Chem., 2017, 15, 8153–8165. The authors regret that there was an omission in the Acknowledgement ...
RSS 1.0