Metal-free transannulation reaction of indoles with nitrostyrenes: a simple practical synthesis of 3-substituted 2-quinolones

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Issue Date
2016-07-15Author
Aksenov, Alexander V.
Smirnov, Alexander N.
Aksenov, Nicolai A.
Aksenova, Inna V.
Frolova, Liliya V.
Kornienko, Alexander
Magedov, Igor V.
Rubin, Michael
Publisher
Royal Society of Chemistry
Type
Article
Article Version
Scholarly/refereed, author accepted manuscript
Metadata
Show full item recordAbstract
3-Substituted 2-quinolones are obtained via a novel, metal-free transannulation reaction of 2-substituted indoles with 2-nitroalkenes in polyphosphoric acid. The reaction can be used in conjunction with the Fisher indole synthesis offering a practical three-component heteroannulation methodology to produce 2-quinolones from arylhydrazines, 2-nitroalkenes and acetophenone.
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Citation
Aksenov, Alexander V., Alexander N. Smirnov, Nicolai A. Aksenov, Inna V. Aksenova, Liliya V. Frolova, Alexander Kornienko, Igor V. Magedov, and Michael Rubin. "Metal-free Transannulation Reaction of Indoles with Nitrostyrenes: A Simple Practical Synthesis of 3-substituted 2-quinolones." Chemical Communications 49.81 (2013): 9305.
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