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Molecular Biosciences: Recent submissions
Now showing items 581-600 of 887
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Precursors to 16S and 23S ribosomal RNA from a ribonuclease III− strain of Escherichia coli contain intact RNase III processing sites
(Oxford University Press, 1980)Escherichia coli cells lacking the ribosomal RNA processing enzyme RNase III do not excise the normal RNA precursors pl6a (17S) and p23a from nascent rRNA transcripts. These cells produce, instead, slightly larger pl6b and ... -
Studies in organisms of colon-aerogenes group : Isolated from various sources /
(University of Kansas, 1919.) -
Inhibition of Tau Aggregation by Three Aspergillus nidulans Secondary Metabolites: 2,ω-Dihydroxyemodin, Asperthecin, and Asperbenzaldehyde
(Georg Thieme Verlag, 2014-01-10)The aggregation of the microtubule-associated protein tau is a significant event in many neurodegenerative diseases including Alzheimerʼs disease. The inhibition or reversal of tau aggregation is therefore a potential ... -
Intraflagellar transport (IFT) during assembly and disassembly of Chlamydomonas flagella
(The Rockefeller University Press, 2005-08-15)Intraflagellar transport (IFT) of particles along flagellar microtubules is required for the assembly and maintenance of eukaryotic flagella and cilia. In Chlamydomonas, anterograde and retrograde particles viewed by light ... -
Monoclinic guanidinoacetate methyltransferase and gadolinium ion-binding characteristics
(International Union of Crystallography, 2003-09-01)Guanidinoacetate methyltransferase (GAMT) is the enzyme that catalyzes the last step of creatine biosynthesis. The enzyme is found in abundance in the livers of all vertebrates. Recombinant rat liver GAMT truncated at amino ... -
Crystallization and preliminary X-ray diffraction studies of d(ACGTAGCTACGT)2:[actinomycin D, (echinomycin)2] and d(ACGTAGCTACGT)2: [actinomycin D, (triostin A)2] complexes
(International Union of Crystallography, 2000-01-01)A DNA-multiple drug complex, d(ACGTAGCTACGT)2:[actinomycin D, (echinomycin)2] has been crystallized. The crystals belong to the monoclinic space group C2, with unit-cell parameters a = 85.6, b = 72.8, c = 56.6 Å, [beta] = ... -
Crystallization and preliminary X-ray diffraction studies of guanidinoacetate methyltransferase from rat liver
(International Union of Crystallography, 1999-01-01)Guanidinoacetate methyltransferase is the enzyme which catalyzes the last step of creatine biosynthesis. The enzyme is found ubiquitously and in abundance in the livers of all vertebrates. Recombinant rat-liver guanidinoacetate ... -
Hydrogen bond studies. 85. A very short, asymmetrical, intramolecular hydrogen bond: A neutron diffraction study of pyridine‐2,3‐dicarboxylic acid (C7H5NO4)
(American Institute of Physics, 1974-01-01)A neutron diffraction study of pyridine‐2,3‐dicarboxylic acid (quinolinic acid) has been carried out. The intensities for 3780 reflexions were measured at the Brookhaven High Flux Beam Reactor. The structure was refined ... -
Seawi—a sea urchin piwi/argonaute family member is a component of MT-RNP complexes
(Cold Spring Harbor Laboratory Press, 2005-01-01)The piwi/argonaute family of proteins is involved in key developmental processes such as stem cell maintenance and axis specification through molecular mechanisms that may involve RNA silencing. Here we report on the cloning ... -
Polyribosome targeting to microtubules: enrichment of specific mRNAs in a reconstituted microtubule preparation from sea urchin embryos
(Rockefeller University Press, 1994-11-15)A subset of mRNAs, polyribosomes, and poly(A)-binding proteins copurify with microtubules from sea urchin embryos. Several lines of evidence indicate that the interaction of microtubules with ribosomes is specific: a ... -
Purification and characterization of oocyte cytoplasmic tubulin and meiotic spindle tubulin of the surf clam Spisula solidissima
(Rockefeller University Press, 1984-01-01)Assembly-competent tubulin was purified from the cytoplasm of unfertilized and parthogenetically activated oocytes, and from isolated meiotic spindles of the surf clam, Spisula solidissima. At 22 degrees C or 37 degrees ... -
Anti-RNA polymerase I antibodies in sera of MRL lpr/lpr and MRL +/+ autoimmune mice. Correlation of antibody production with delayed onset of lupus-like disease in MRL +/+ mice
(Rockefeller University Press, 1985-12-01)Sera from individual MRL/lpr and MRL/++ mice, which develop an autoimmune disease similar to human systemic lupus erythematosus (SLE), were screened over a period of approximately 30 wk for the presence of anti-RNA polymerase ... -
Defective flagellar assembly and length regulation in LF3 null mutants in Chlamydomonas
(The Rockefeller University Press, 2003-11-10)Four long-flagella (LF) genes are important for flagellar length control in Chlamydomonas reinhardtii. Here, we characterize two new null lf3 mutants whose phenotypes are different from previously identified lf3 mutants. ... -
Selectivity by Small-Molecule Inhibitors of Protein Interactions Can Be Driven by Protein Surface Fluctuations
(Public Library of Sciences, 2015-02-23)Small-molecules that inhibit interactions between specific pairs of proteins have long represented a promising avenue for therapeutic intervention in a variety of settings. Structural studies have shown that in many cases, ... -
Cytoplasmic Dynein Heavy Chain 1b Is Required for Flagellar Assembly in Chlamydomonas
(American Society for Cell Biology, 1999-03-01)A second cytoplasmic dynein heavy chain (cDhc) has recently been identified in several organisms, and its expression pattern is consistent with a possible role in axoneme assembly. We have used a genetic approach to ask ... -
Ciliary microtubule capping structures contain a mammalian kinetochore antigen
(Rockefeller University Press, 1990-03-01)Structures that cap the plus ends of microtubules may be involved in the regulation of their assembly and disassembly. Growing and disassembling microtubules in the mitotic apparatus are capped by kinetochores and ciliary ... -
Release of intact microtubule-capping structures from Tetrahymena cilia
(Rockefeller University Press, 1988-12-01)The distal ends of ciliary microtubules are attached to the membrane by microtubule-capping structures. The capping structures are located at the sites of tubulin addition and loss in vivo and may be part of the regulatory ... -
Fractionation of Tetrahymena ciliary membranes with triton X-114 and the identification of a ciliary membrane ATPase
(Rockefeller University Press, 1988-12-01)Cilia were isolated from Tetrahymena thermophila, extracted with Triton X-114, and the detergent-soluble membrane + matrix proteins separated into Triton X-114 aqueous and detergent phases. The aqueous phase polypeptides ... -
Association between endocrine pancreatic secretory granules and in-vitro-assembled microtubules is dependent upon microtubule-associated proteins
(Rockefeller University Press, 1982-04-01)By use of dark-field light microscopy, secretory granules isolated from the anglerfish endocrine pancreas were observed to attach to and release from microtubules assembled in vitro from brain homogenates. Secretory granules ... -
Microtubule-associated proteins (MAPs) and the organization of actin filaments in vitro
(Rockefeller University Press, 1981-08-01)When purified muscle actin was mixed with microtubule-associated proteins (MAPs) prepared from brain microtubules assembled in vitro, actin filaments were organized into discrete bundles, 26 nm in diameter. MAP-2 was the ...