Molecular Biosciences
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Efflux Pumps Represent Possible Evolutionary Convergence onto the Beta Barrel Fold
(bioRxiv, 2018-02-19)There are around 100 types of integral outer membrane proteins in each Gram negative bacteria. All of these proteins have the same fold—an up-down β-barrel. It has been suggested that all membrane β-barrels other than ... -
Naturally Segregating Variation at Ugt86Dd Contributes to Nicotine Resistance in Drosophila melanogaster
(ASTM International, 2017-07-10)Identifying the sequence polymorphisms underlying complex trait variation is a key goal of genetics research, since knowing the precise causative molecular events allows insight into the pathways governing trait variation. ... -
Identification of novel small molecule Beclin 1 mimetics activating autophagy
(Impact Journals, 2017-05-18)Anti-apoptotic proteins Bcl-2 and Bcl-xL could block autophagy by binding to Beclin 1 protein, an essential inducer of autophagy. Compounds mimicking Beclin 1 might be able to disrupt Bcl-xL/2-Beclin 1 interaction, free ... -
HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells
(Nature Research, 2017-08-30)Human antigen (Hu) R is an RNA-binding protein whose overexpression in human cancer correlates with aggressive disease, drug resistance, and poor prognosis. HuR inhibition has profound anticancer activity. Pharmacologic ... -
Human oncoprotein Musashi-2 N-terminal RNA recognition motif backbone assignment and identification of RNA-binding pocket
(Impact Journals, 2017-11-20)RNA-binding protein Musashi-2 (MSI2) is a key regulator in stem cells, it is over-expressed in a variety of cancers and its higher expression is associated with poor prognosis. Like Musashi-1, it contains two N-terminal ... -
The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro
(Public Library of Science, 2017-04-17)The RNA-binding protein Hu antigen R (HuR) binds to AU-rich elements (ARE) in the 3’-untranslated region (UTR) of target mRNAs. The HuR-ARE interactions stabilize many oncogenic mRNAs that play important roles in tumorigenesis. ... -
Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus
(BMC, 2017-02-14)Background The fungal genus Aspergillus is of critical importance to humankind. Species include those with industrial applications, important pathogens of humans, animals and crops, a source of potent carcinogenic ... -
Flavin monooxygenases regulate Caenorhabditis elegans axon guidance and growth cone protrusion with UNC-6/Netrin signaling and Rac GTPases
(Public Library of Science, 2017-08-31)The guidance cue UNC-6/Netrin regulates both attractive and repulsive axon guidance. Our previous work showed that in C. elegans, the attractive UNC-6/Netrin receptor UNC-40/DCC stimulates growth cone protrusion, and that ... -
Non-Catalytic Roles of the Topoisomerase IIα C-Terminal Domain
(MDPI, 2017)DNA Topoisomerase II (Topo II ) is a ubiquitous enzyme in eukaryotes that performs the strand passage reaction where a double helix of DNA is passed through a second double helix. This unique reaction is critical for ... -
Identification of a new small ubiquitin-like modifier (SUMO)-interacting motif in the E3 ligase PIASy
(American Society for Biochemistry and Molecular Biology, 2017)Small ubiquitin-like modifier (SUMO) conjugation is a reversible post-translational modification process implicated in the regulation of gene transcription, DNA repair, and cell cycle. SUMOylation depends on the sequential ... -
Draft Genome Sequence of Lysinibacillus fusiformis Strain Juneja, a Laboratory-Derived Pathogen of Drosophila melanogaster
(American Society for Microbiology, 2018-02-01)Drosophila melanogaster is a model for the study of innate immunity, yet we have limited knowledge of its natural pathogens. In this study, we sequenced the genome of Lysinibacillus fusiformis strain Juneja, isolated from ... -
MTBP inhibits the Erk1/2-Elk-1 signaling in hepatocellular carcinoma
(Impact Journals, 2018-04-20)Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and the prognosis of HCC patients, especially those with metastasis, remains extremely poor. This is partly due to unclear molecular mechanisms ... -
Bacterial Quorum Sensing and Microbial Community Interactions
(American Society for Microbiology, 2018-05-22)Many bacteria use a cell-cell communication system called quorum sensing to coordinate population density-dependent changes in behavior. Quorum sensing involves production of and response to diffusible or secreted signals, ... -
Transmission Dynamics of Bovine Anaplasmosis in a Cattle Herd
(Hindawi Publishing Corporation, 2018-05-02)Bovine anaplasmosis is an infectious disease of cattle caused by the obligate intercellular bacterium, Anaplasma marginale, and it primarily occurs in tropical and subtropical regions of the world. In this study, an ... -
Ligand Binding Pathways and Conformational Transitions of the HIV Protease
(Biochemistry, 2018-03-06)It is important to determine the binding pathways and mechanisms of ligand molecules to target proteins to effectively design therapeutic drugs. Molecular dynamics (MD) is a promising computational tool that allows us to ... -
Characterization of Small Molecule Scaffolds that Bind to the Shigella Type III Secretion System Protein IpaD
(Wiley, 2017-09-21)Many pathogens such as Shigella and other bacteria assemble the type III secretion system (T3SS) nanoinjector to inject virulence proteins into their target cells to cause infectious diseases in humans. The rise of drug ... -
Template-Based Modeling of Protein-RNA Interactions
(Public Library of Science, 201-09-23)Protein-RNA complexes formed by specific recognition between RNA and RNA-binding proteins play an important role in biological processes. More than a thousand of such proteins in human are curated and many novel RNA-binding ... -
EGL-20/Wnt and MAB-5/Hox Act Sequentially to Inhibit Anterior Migration of Neuroblasts in C. elegans
(Public Library of Science, 2016-02-10)Directed neuroblast and neuronal migration is important in the proper development of nervous systems. In C. elegans the bilateral Q neuroblasts QR (on the right) and QL (on the left) undergo an identical pattern of cell ... -
Cellular Growth Arrest and Persistence from Enzyme Saturation
(Public Library of Science, 2016-03-24)Metabolic efficiency depends on the balance between supply and demand of metabolites, which is sensitive to environmental and physiological fluctuations, or noise, causing shortages or surpluses in the metabolic pipeline. ... -
Annual Greenland accumulation rates (2009–2012) from airborne snow radar
(European Geosciences Union, 2016-08-11)Contemporary climate warming over the Arctic is accelerating mass loss from the Greenland Ice Sheet through increasing surface melt, emphasizing the need to closely monitor its surface mass balance in order to improve ...
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