Molecular Biosciences
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Characterization of Small Molecule Scaffolds that Bind to the Shigella Type III Secretion System Protein IpaD
(Wiley, 2017-09-21)Many pathogens such as Shigella and other bacteria assemble the type III secretion system (T3SS) nanoinjector to inject virulence proteins into their target cells to cause infectious diseases in humans. The rise of drug ... -
Template-Based Modeling of Protein-RNA Interactions
(Public Library of Science, 201-09-23)Protein-RNA complexes formed by specific recognition between RNA and RNA-binding proteins play an important role in biological processes. More than a thousand of such proteins in human are curated and many novel RNA-binding ... -
EGL-20/Wnt and MAB-5/Hox Act Sequentially to Inhibit Anterior Migration of Neuroblasts in C. elegans
(Public Library of Science, 2016-02-10)Directed neuroblast and neuronal migration is important in the proper development of nervous systems. In C. elegans the bilateral Q neuroblasts QR (on the right) and QL (on the left) undergo an identical pattern of cell ... -
Cellular Growth Arrest and Persistence from Enzyme Saturation
(Public Library of Science, 2016-03-24)Metabolic efficiency depends on the balance between supply and demand of metabolites, which is sensitive to environmental and physiological fluctuations, or noise, causing shortages or surpluses in the metabolic pipeline. ... -
Annual Greenland accumulation rates (2009–2012) from airborne snow radar
(European Geosciences Union, 2016-08-11)Contemporary climate warming over the Arctic is accelerating mass loss from the Greenland Ice Sheet through increasing surface melt, emphasizing the need to closely monitor its surface mass balance in order to improve ... -
Mapping QTL Contributing to Variation in Posterior Lobe Morphology between Strains of Drosophila melanogaster
(PLoS, 2016-09-08)Closely-related, and otherwise morphologically similar insect species frequently show striking divergence in the shape and/or size of male genital structures, a phenomenon thought to be driven by sexual selection. Comparative ... -
Genetic analysis of variation in lifespan using a multiparental advanced intercross Drosophila mapping population
(BioMed Central, 2016-08-02)Background: Considerable natural variation for lifespan exists within human and animal populations. Genetically dissecting this variation can elucidate the pathways and genes involved in aging, and help uncover the genetic ... -
Quorum Sensing Influences Burkholderia thailandensis Biofilm Development and Matrix Production
(American Society for Microbiology, 2016-04-11)Members of the genus Burkholderia are known to be adept at biofilm formation, which presumably assists in the survival of these organisms in the environment and the host. Biofilm formation has been linked to quorum sensing ... -
Draft Genome Sequence of Chromobacterium violaceum Strain CV017
(American Society for Microbiology, 2016-03-03)We announce the draft genome sequence for Chromobacterium violaceum strain CV017, used as a model and tool to understand acyl-homoserine lactone-dependent quorum sensing. The assembly consists of 4,774,638-bp contained in ... -
Gemcitabine enhances cell invasion via activating HAb18G/CD147-EGFR-pSTAT3 signaling
(Impact Journals, 2016-08-19)Pancreatic cancer, one of the most lethal cancers, has very poor 5-year survival partly due to gemcitabine resistance. Recently, it was reported that chemotherapeutic agents may act as stressors to induce adaptive responses ... -
Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis
(Impact Journals, 2016-09-22)Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-related mortality. Observed during CRC tumorigenesis is loss of post-transcriptional regulation of tumor-promoting genes such as COX-2, ... -
Overcoming chemo/radio-resistance of pancreatic cancer by inhibiting STAT3 signaling
(Impact Journals, 2016-02-12)Chemo/radio-therapy resistance to the deadly pancreatic cancer is mainly due to the failure to kill pancreatic cancer stem cells (CSCs). Signal transducer and activator of transcription 3 (STAT3) is activated in pancreatic ... -
SUMOylation of DNA topoisomerase IIα regulates histone H3 kinase Haspin and H3 phosphorylation in mitosis
(Rockefeller University Press, 2016-06-20)DNA topoisomerase II (TOP2) plays a pivotal role in faithful chromosome separation through its strand-passaging activity that resolves tangled genomic DNA during mitosis. Additionally, TOP2 controls progression of mitosis ... -
Natural product (L)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1
(Wiley Open Access, 2015-04-10)Musashi-1 (MSI1) is an RNA-binding protein that acts as a translation activator or repressor of target mRNAs. The best-characterized MSI1 target is Numb mRNA, whose encoded protein negatively regulates Notch signaling. ... -
Overexpression of the Aspergillus nidulans histone 4 acetyltransferase EsaA increases activation of secondary metabolite production
(Wiley, 2012-10)Regulation of secondary metabolite (SM) gene clusters in Aspergillus nidulans has been shown to occur through cluster specific transcription factors or through global regulators of chromatin structure such as histone ... -
Chlamydia trachomatis protein CT009 is a structural and functional homolog to the key morphogenesis component RodZ and interacts with division septal plane localized MreB
(Wiley, 2015-02)Cell division in Chlamydiae is poorly understood as apparent homologs to most conserved bacterial cell division proteins are lacking and presence of elongation (rod shape) associated proteins indicate non-canonical mechanisms ... -
A de novo protein binding pair by computational design and directed evolution
(Elsevier, 2011-04-22)The de novo design of protein-protein interfaces is a stringent test of our understanding of the principles underlying protein-protein interactions and would enable new approaches to biological and medical challenges. Here ... -
Molecular genetic analysis of the orsellinic acid/F9775 gene cluster of Aspergillus nidulans†,‡
(Royal Society of Chemistry, 2010-03)F-9775A and F-9775B are cathepsin K inhibitors that arise from a chromatin remodelling deletant strain of Aspergillus nidulans. A polyketide synthase gene has been determined to be responsible for their formation and for ... -
Identification and molecular genetic analysis of the cichorine gene cluster in Aspergillus nidulans
(Royal Society of Chemistry, 2012-08-01)We recently demonstrated that the phytotoxin cichorine is produced by Aspergillus nidulans. Through a set of targeted deletions, we have found a cluster of seven genes that are required for its biosynthesis. Two of the ... -
Sec61á is required for dorsal closure during Drosophila embryogenesis through its regulation of Dpp signaling
(Wiley, 2010-03)During dorsal closure in Drosophila, signaling events in the dorsalmost row of epidermal cells (DME cells) direct the migration of lateral epidermal sheets towards the dorsal midline where they fuse to enclose the embryo. ...
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