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Mitotic SUMOylation: Unraveling the role of DNA Topoisomerase IIα SUMOylation and PIASy SUMO E3 ligase in mitosis
(University of Kansas, 2019-12-31)A post-translational modification with SUMO (SUMOylation) can regulate various cellular events such as DNA replication, repair, transcription and cell cycle regulation. Many studies have indicated that SUMOylation is crucial ... -
Polycyclic aromatic hydrocarbons influence naive CD4+ T cell differentiation
(University of Kansas, 2019-12-31)CD4+ T cells are essential for the effective functioning and appropriate regulation of the immune system. Antigen-naïve T cells require two distinct costimulatory signals to activate and differentiate into effector and ... -
The phage gene wmk is a candidate for male killing by a bacterial endosymbiont
(Public Library of Science, 2019-09-10)Wolbachia are the most widespread maternally-transmitted bacteria in the animal kingdom. Their global spread in arthropods and varied impacts on animal physiology, evolution, and vector control are in part due to parasitic ... -
MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infection
(Public Library of Science, 2018-01-25)Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel human coronavirus that emerged in 2012, causing severe pneumonia and acute respiratory distress syndrome (ARDS), with a case fatality rate of ~36%. When ... -
THE ROAD LESS TRAVELLED: UTILIZATION OF FORMATE IN TWO BIOCHEMICAL REACTIONS IN GRAM-NEGATIVE BACTERIA
(University of Kansas, 2019-08-31)Formate is an important intermediate in a number of metabolic reactions. Most of the formate pool in cells is generated from the degradation of primary metabolites (glucose, pyruvate, amino acids) and further degraded into ... -
The Biosynthesis of Opine Metallophores
(University of Kansas, 2019-08-31)Metal acquisition is a necessity for all cells as metals are essential for the function of numerous metalloproteins and metalloenzymes. Bacterial pathogens employ several strategies for obtaining necessary metal including ... -
Gene silencing in the nucleus: mechanisms and new phenomena
(University of Kansas, 2019-08-31)Silencing of homologous genes by exogenously introduced dsRNA was first observed in C. elegans. Endogenous small RNAs (siRNAs, piRNAs, miRNAs) mediate regulation of expression of genes post-transcriptionally or at the level ... -
Cyclin A Degradation by Primate Cytomegalovirus Protein pUL21a Counters Its Innate Restriction of Virus Replication
(Public Library of Science, 2013-12-26)Cyclin A is critical for cellular DNA synthesis and S phase progression of the cell cycle. Human cytomegalovirus (HCMV) can reduce cyclin A levels and block cellular DNA synthesis, and cyclin A overexpression can repress ... -
Proteasome-Dependent Disruption of the E3 Ubiquitin Ligase Anaphase-Promoting Complex by HCMV Protein pUL21a
(Public Library of Science, 2012-07-05)The anaphase-promoting complex (APC) is an E3 ubiquitin ligase which controls ubiquitination and degradation of multiple cell cycle regulatory proteins. During infection, human cytomegalovirus (HCMV), a widespread pathogen, ... -
Assembly of a heptameric STRIPAK complex is required for coordination of light-dependent multicellular fungal development with secondary metabolism in Aspergillus nidulans
(Public Library of Science, 2019-03-18)Eukaryotic striatin forms striatin-interacting phosphatase and kinase (STRIPAK) complexes that control many cellular processes including development, cellular transport, signal transduction, stem cell differentiation and ... -
RHO-1 and the Rho GEF RHGF-1 interact with UNC-6/Netrin signaling to regulate growth cone protrusion and microtubule organization in Caenorhabditis elegans
(Public Library of Science, 2019-06-24)UNC-6/Netrin is a conserved axon guidance cue that directs growth cone migrations in the dorsal-ventral axis of C. elegans and in the vertebrate spinal cord. UNC-6/Netrin is expressed in ventral cells, and growth cones ... -
The Non-Coding RNA Journal Club: Highlights on Recent Papers—7
(MDPI, 2019-06-11) -
Disordered RNA chaperones can enhance nucleic acid folding via local charge screening
(Nature Research, 2019-06-05)RNA chaperones are proteins that aid in the folding of nucleic acids, but remarkably, many of these proteins are intrinsically disordered. How can these proteins function without a well-defined three-dimensional structure? ... -
Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses
(American Society for Microbiology, 2018-05-01)Selective packaging is a mechanism used by multiple virus families to specifically incorporate genomic RNA (gRNA) into virions and exclude other types of RNA. Lineage A betacoronaviruses incorporate a 95-bp stem-loop ... -
Topoisomerase II SUMOylation activates a metaphase checkpoint via Haspin and Aurora B kinases
(Rockefeller University Press, 2019-11-11)Topoisomerase II (Topo II) is essential for mitosis since it resolves sister chromatid catenations. Topo II dysfunction promotes aneuploidy and drives cancer. To protect from aneuploidy, cells possess mechanisms to delay ... -
Staphylopine and pseudopaline dehydrogenase from bacterial pathogens catalyze reversible reactions and produce stereospecific metallophores
(American Society for Biochemistry and Molecular Biology, 2019-11-22)Pseudopaline and staphylopine are opine metallophores biosynthesized by Pseudomonas aeruginosa and Staphylococcus aureus, respectively. The final step in opine metallophore biosynthesis is the condensation of the product ... -
Host-pathogen coevolution increases genetic variation in susceptibility to infection
(eLife Sciences Publications, 2019-04-30)It is common to find considerable genetic variation in susceptibility to infection in natural populations. We have investigated whether natural selection increases this variation by testing whether host populations show ... -
Detachment Activated CyPA/CD147 Induces Cancer Stem Cell Potential in Non-stem Breast Cancer Cells
(Frontiers Media, 2020-10-16)Background: Cancer stem cells (CSCs), responsible for cancer metastasis and recurrence, are generated from non-CSCs after chemo-radiation therapy. This study investigated the induction of CSC potential in non-stem breast ... -
A Computational Modeling Approach Predicts Interaction of the Antifungal Protein AFP from Aspergillus giganteus with Fungal Membranes via Its γ-Core Motif
(American Society for Microbiology, 2018-10-03)Fungal pathogens kill more people per year globally than malaria or tuberculosis and threaten international food security through crop destruction. New sophisticated strategies to inhibit fungal growth are thus urgently ... -
Structural Basis for Binding of Allosteric Drug Leads in the Adenosine A1 Receptor
(Nature Research, 2018-11-15)Despite intense interest in designing positive allosteric modulators (PAMs) as selective drugs of the adenosine A1 receptor (A1AR), structural binding modes of the receptor PAMs remain unknown. Using the first X-ray structure ...
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