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Deep Learning Dynamic Allostery of G-Protein-Coupled Receptors
(ACS Publications, 2023-11-02)G-protein-coupled receptors (GPCRs) make up the largest superfamily of human membrane proteins and represent primary targets of ∼1/3 of currently marketed drugs. Allosteric modulators have emerged as more selective drug ... -
Evolution of a ZW sex chromosome system in willows
(Nature Research, 2023-11-06)Transitions in the heterogamety of sex chromosomes (e.g., XY to ZW or vice versa) fundamentally alter the genetic basis of sex determination, however the details of these changes have been studied in only a few cases. In ... -
Fungal secondary metabolism is governed by an RNA-binding protein CsdA/RsdA complex
(Nature Research, 2023-11-14)Production of secondary metabolites is controlled by a complicated regulatory network in eukaryotic cells. Several layers of regulators are involved in this process, ranging from pathway-specific regulation, to epigenetic ... -
Unlocking the microbiome
(eLife Sciences Publications, 2023-10-11)Individual species of bacteria and yeast present in the food of wild fruit flies work together to provide the nutrients needed for larval growth. -
A heterologous expression platform in Aspergillus nidulans for the elucidation of cryptic secondary metabolism biosynthetic gene clusters: discovery of the Aspergillus fumigatus sartorypyrone biosynthetic pathway
(Royal Society of Chemistry, 2023-06-26)Aspergillus fumigatus is a serious human pathogen causing life-threatening Aspergillosis in immunocompromised patients. Secondary metabolites (SMs) play an important role in pathogenesis, but the products of many SM ... -
Evolution of five environmentally responsive gene families in a pine‐feeding sawfly, Neodiprion lecontei (Hymenoptera: Diprionidae
(Wiley Open Access, 2023-10-01)A central goal in evolutionary biology is to determine the predictability of adaptive genetic changes. Despite many documented cases of convergent evolution at individual loci, little is known about the repeatability of ... -
Functional inhibition of the RNA‐binding protein HuR sensitizes triple‐negative breast cancer to chemotherapy
(FEBS PRESS, 2023-07-19)Chemotherapy remains the standard treatment for triple‐negative breast cancer (TNBC); however, chemoresistance compromises its efficacy. The RNA‐binding protein Hu antigen R (HuR) could be a potential therapeutic target ... -
An Update on the Current State of SARS-CoV-2 Mac1 Inhibitors
(MDPI, 2023-10-07)Non-structural protein 3 (nsp3) from all coronaviruses (CoVs) contains a conserved macrodomain, known as Mac1, that has been proposed as a potential therapeutic target for CoVs due to its critical role in viral pathogenesis. ... -
Hybrid Inquiry-Based Laboratory Curriculum Highlights Scientific Method Using Bacterial Conjugation as a Model
(American Society for Microbiology, 2023-05-01)Undergraduate microbiology students are exposed to the theory of the scientific method throughout their undergraduate coursework, but laboratory course curricula often focus on technical skills rather than fully integrating ... -
Structural basis of agonist specificity of α1A-adrenergic receptor
(Nature Research, 2023-08-10)α1-adrenergic receptors (α1-ARs) play critical roles in the cardiovascular and nervous systems where they regulate blood pressure, cognition, and metabolism. However, the lack of specific agonists for all α1 subtypes has ... -
The genetic basis of variation in immune defense against Lysinibacillus fusiformis infection in Drosophila melanogaster
(Public Library of Science, 2023-08-07)The genetic causes of phenotypic variation often differ depending on the population examined, particularly if the populations were founded by relatively small numbers of genotypes. Similarly, the genetic causes of phenotypic ... -
Use of gene sequences as type for naming prokaryotes: Recommendations of the international committee on the taxonomy of chlamydiae
(Elsevier, 2023-09)The International Committee on Systematics of Prokaryotes (ICSP) discussed and rejected in 2020 a proposal to modify the International Code of Nomenclature of Prokaryotes to allow the use of gene sequences as type for ... -
Repurposing Niclosamide as a Novel Anti-SARS-CoV-2 Drug by Restricting Entry Protein CD147
(MDPI, 2023-07-18)The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the global coronavirus disease 2019 (COVID-19) pandemic, and the search for effective treatments has been limited. Furthermore, the ... -
Targeting RNA-binding protein HuR to inhibit the progression of renal tubular fibrosis
(BMC, 2023-06-30)Background Upregulation of an RNA-binding protein HuR has been implicated in glomerular diseases. Herein, we evaluated whether it is involved in renal tubular fibrosis. Methods HuR was firstly examined in human kidney ... -
Protein folds vs. protein folding: Differing questions, different challenges
(National Academy of Sciences, 2022-12-29) -
Herpes Simplex Virus 1 (HSV-1) Infected Cell Protein 0 (ICP0) Targets of Ubiquitination during Productive Infection of Primary Adult Sensory Neurons
(MDPI, 2023-02-02)Herpes simplex virus 1 (HSV-1) enters sensory neurons with the potential for productive or latent infection. For either outcome, HSV-1 must curtail the intrinsic immune response, regulate viral gene expression, and remove ... -
Methylated histones on mitotic chromosomes promote topoisomerase IIα function for high fidelity chromosome segregation
(Cell Press, 2023-05-19)DNA Topoisomerase IIα (TopoIIα) decatenates sister chromatids, allowing their segregation in mitosis. Without the TopoIIα Strand Passage Reaction (SPR), chromosome bridges and ultra-fine DNA bridges (UFBs) arise in anaphase. ... -
Genetic variation in chromatin state across multiple tissues in Drosophila melanogaster
(Public Library of Science, 2023-05-05)We use ATAC-seq to examine chromatin accessibility for four different tissues in Drosophila melanogaster: adult female brain, ovaries, and both wing and eye-antennal imaginal discs from males. Each tissue is assayed in ... -
Cross-species activation of hydrogen cyanide production by a promiscuous quorum-sensing receptor promotes Chromobacterium subtsugae competition in a dual-species model
(Microbiology Society, 2023-02-15)Many saprophytic bacteria have LuxR-I-type acyl-homoserine lactone (AHL) quorum-sensing systems that may be important for competing with other bacteria in complex soil communities. LuxR AHL receptors specifically interact ... -
Conversion of Polyethylenes into Fungal Secondary Metabolites
(Wiley, 2022-11-03)Waste plastics represent major environmental and economic burdens due to their ubiquity, slow breakdown rates, and inadequacy of current recycling routes. Polyethylenes are particularly problematic, because they lack robust ...