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Molecular Biosciences: Recent submissions
Now showing items 601-620 of 887
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Microtubule-membrane interactions in cilia. II. Photochemical cross-linking of bridge structures and the identification of a membrane-associated dynein-like ATPase
(Rockefeller University Press, 1980-02-01)Photochemical cross-linking of both Tetrahymena and Aequipecten ciliary membrane proteins with the lipophilic reagent 4,4'-dithiobisphenylazide links together a high molecular weight dynein-like ATPase, membrane tubulin, ... -
Microtubule-membrane interactions in cilia. I. Isolation and characterization of ciliary membranes from Tetrahymena pyriformis
(Rockefeller University Press, 1980-02-01)Tetrahymena ciliary membranes were prepared by four different techniques, and their protein composition was analyzed by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), electron microscopy, and ... -
Flagellar elongation and shortening in Chlamydomonas. III. structures attached to the tips of flagellar microtubules and their relationship to the directionality of flagellar microtubule assembly
(Rockefeller University Press, 1977-09-01)Two structures on the distal ends of Chlamydomonas flagellar microtubules are described. One of these, the central microbutule cap, attaches the distal ends of the central pair microtubules to the tip of the flagellar ... -
Ultrastructural localization of the high molecular weight proteins associated with in vitro-assembled brain microtubules
(Rockefeller University Press, 1975-04-01)Microtubules isolated from brain extracts by in vitro assembly (1, 19, 23) are composed principally of two tubulins and two high molecular weight proteins (microtubule-associated proteins [MAPS] 1 and 2) (2,5,7,20). Recently, ... -
Sizing Up Allometric Scaling Theory
(Public Library of Science, 2008-09-12)Metabolic rate, heart rate, lifespan, and many other physiological properties vary with body mass in systematic and interrelated ways. Present empirical data suggest that these scaling relationships take the form of power ... -
Protein structure and evolutionary history determine sequence space topology
(Cold Spring Harbor Laboratory Press, 2005-01-01)Understanding the observed variability in the number of homologs of a gene is a very important unsolved problem that has broad implications for research into coevolution of structure and function, gene duplication, pseudogene ... -
Prokaryotic phylogenies inferred from protein structural domains
(Cold Spring Harbor Laboratory Press, 2005-01-01)The determination of the phylogenetic relationships among microorganisms has long relied primarily on gene sequence information. Given that prokaryotic organisms often lack morphological characteristics amenable to ... -
Semiconservative replication in the quasispecies model
(American Physical Society, 2004-06-16)This paper extends Eigen’s quasispecies equations to account for the semiconservative nature of DNA replication. We solve the equations in the limit of infinite sequence length for the simplest case of a static, sharply ... -
Equilibrium Distribution of Mutators in the Single Fitness Peak Model
(American Physical Society, 2003-09-26)This Letter develops an analytically tractable model for determining the equilibrium distribution of mismatch repair deficient strains in unicellular populations. The approach is based on the single fitness peak model, ... -
Structure of the Yersinia pestis tip protein LcrV refined to 1.65 A resolution
(International Union of Crystallography, 2013-05-01)The human pathogen Yersinia pestis requires the assembly of the type III secretion system (T3SS) for virulence. The structural component of the T3SS contains an external needle and a tip complex, which is formed by LcrV ... -
The structure of the hantavirus zinc finger domain is conserved and represents the only natively folded region of the Gn cytoplasmic tail
(Frontiers, 2011-12-01)Hantaviruses, of the family Bunyaviridae, are present throughout the world and cause a variety of infections ranging from the asymptomatic to mild and severe hemorrhagic fevers. Hantaviruses are enveloped anti-sense RNA ... -
The UNC-6/Netrin receptors UNC-40/DCC and UNC-5 inhibit growth cone filopodial protrusion via UNC-73/Trio, Rac-like GTPases and UNC-33/CRMP
(Company of Biologists, 2014-11-15)UNC-6/Netrin is a conserved axon guidance cue that can mediate both attraction and repulsion. We previously discovered that attractive UNC-40/DCC receptor signaling stimulates growth cone filopodial protrusion and that ... -
A Phospho-SIM in the Antiviral Protein PML is Required for Its Recruitment to HSV-1 Genomes
(MDPI, 2014-12-10)Herpes simplex virus type 1 (HSV-1) is a significant human pathogen that infects a large portion of the human population. Cells deploy a variety of defenses to limit the extent to which the virus can replicate. One such ... -
Ewing Sarcoma Eswa Protein Regulates Chondrogenesis of Meckel's Cartilage through Modulation of Sox9 in Zebrafish
(Public Library of Science, 2015-01-24)Ewing sarcoma is the second most common skeletal (bone and cartilage) cancer in adolescents, and it is characterized by the expression of the aberrant chimeric fusion gene EWS/FLI1. Wild-type EWS has been proposed to play ... -
Elucidation of the Mechanisms of Nucleosome Binding and Repositioning by a Chromatin Remodeler: Monomeric ISWI Remodels Nucleosomes Through a Random Walk
(University of Kansas, 2014-05-31)The regulation of chromatin structure is controlled by a family of molecular motors called chromatin remodelers. The ability of these enzymes to remodel chromatin structure is dependent on their ability to couple ATP binding ... -
Developing A Bitwise Macromolecular Assembly Simulator
(University of Kansas, 2014-08-31)Macromolecular machines play fundamental roles in many cellular tasks, from intracellular transport to protein synthesis and degradation. The majority of these machines must adopt a particular quaternary structure in order ... -
IDENTIFYING AND CHARACTERIZING THE ROLES OF TRANSMEMBRANE PROTEINS IN DIRECTING ASYMMETRIC Q NEUROBLAST MIGRATIONS
(University of Kansas, 2014-08-31)Migration of neurons is essential for proper nervous system development. Defects in neural development can lead to several neurological disorders. Hence it is important to understand the mechanism of neuronal migration ... -
MicroRNA Expression can be a Promising Strategy for the Detection of Barrett's Esophagus: A Pilot Study
(Nature Publishing Group, 2014-12-11)Patient outcomes for esophageal adenocarcinoma (EAC) have not improved despite huge advances in endoscopic therapy because cancers are being diagnosed late. Barrett's esophagus (BE) is the primary precursor lesion for EAC, ... -
MIP-1α Induces Differential MAP Kinase Activation and IκB Gene Expression in Human B Lymphocytes
(Mary Ann Liebert, Inc., 2004-07-24)The chemokine macrophage inflammatory protein-1α (MIP-1α) stimulates migration of B cells and affects B cell immunoglobulin production. However, the molecular mechanisms by which MIP-1α modulates these biologic effects ... -
Adherence-dependent Increase in Human Monocyte PDGF(B) mRNA Is Associated with Increases in c-fos, c-jun, and EGR2 mRNA
(The Rockefeller University Press, 1990-11-01)Adherence is an important initial step in the transition of a circulating monocyte to a tissue macrophage. This differentiation is accompanied by an augmented capacity to generate growth factors. We hypothesized that ...