Selectivity by Small-Molecule Inhibitors of Protein Interactions Can Be Driven by Protein Surface Fluctuations
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Antiparallel Dimers of the Small Multidrug Resistance Protein EmrE Are More Stable Than Parallel Dimers Lloris-Garcerá, Pilar; Bianchi, Frans; Slusky, Joanna; Seppälä, Susanna; Daley, Daniel O.; von Heijne, Gunnar (American Society for Biochemistry and Molecular Biology, 2012-06-14)The bacterial multidrug transporter EmrE is a dual-topology membrane protein and as such is able to insert into the membrane in two opposite orientations. The functional form of EmrE is a homodimer; however, the relative ...
Wang, Jinan; Miao, Yinglong (Elsevier, 2019-01-03)Protein-protein interactions are key in cellular signaling. G protein-coupled receptors (GPCRs), the largest superfamily of human membrane proteins, are able to transduce extracellular signals (e.g., hormones and ...
Karanicolas, John; Kuhlman, Brian (Elsevier, 2009-08)The computer-based design of protein-protein interactions is a rigorous test of our understanding of molecular recognition and an attractive approach for creating novel tools for cell and molecular research. Considerable ...