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Molecular Biosciences: Recent submissions
Now showing items 561-580 of 887
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Changes in Temporal and Spatial Patterns of Outer Surface Lipoprotein Expression Generate Population Heterogeneity and Antigenic Diversity in the Lyme Disease Spirochete, Borrelia burgdorferi
(American Society for Microbiology, 2002-07)Borrelia burgdorferi differentially expresses many of the OspE/F/Elp paralogs during tick feeding. These findings, combined with the recent report that stable B. burgdorferi infection of mammals occurs only after 53 h of ... -
Regulation of OspE-Related, OspF-Related, and Elp Lipoproteins of Borrelia burgdorferi Strain 297 by Mammalian Host-Specific Signals
(American Society for Microbiology, 2001-06)In previous studies we have characterized the cp32/18 loci inBorrelia burgdorferi 297 which encode OspE and OspF orthologs and a third group of lipoproteins which possess OspE/F-like leader peptides (Elps). To further these ... -
Evidence for an RNA-based catalytic mechanism in eukaryotic nuclear ribonuclease P.
(RNA Society, 2000)Ribonuclease P is the enzyme responsible for removing the 5'-leader segment of precursor transfer RNAs in all organisms. All eukaryotic nuclear RNase Ps are ribonucleoproteins in which multiple protein components and a ... -
Enzyme nomenclature: Functional or structural?
(Cambridge University Press, 2000-12)Altman and colleagues (this issue) call attention to the inability of current standardized enzyme nomenclature to distinguish between enzymatic activities that reside in nonhomologous macromolecules. This issue is highlighted ... -
Chloroplast ribonuclease P does not utilize the ribozyme-type pre-tRNA cleavage mechanism.
(RNA Society, 2000)The transfer RNA 5' maturation enzyme RNase P has been characterized in Bacteria, Archaea, and Eukarya. The purified enzyme from all three kingdoms is a ribonucleoprotein containing an essential RNA subunit; indeed, the ... -
Cleavage specificity of chloroplast and nuclear tRNA 3'-processing nucleases.
(American Society for Microbiology, 1992-02)tRNAs in eukaryotic nuclei and organelles are synthesized as precursors lacking the 3'-terminal CCA sequence and possessing 5' (leader) and 3' (trailer) extensions. Nucleolytic cleavage of the 3' trailer and addition of ... -
Chasing Funnels on Protein-Protein Energy Landscapes at Different Resolutions
(Biophysical Society, 2008-09-01)Studies of intermolecular energy landscapes are important for understanding protein association and adequate modeling of protein interactions. Landscape representation at different resolutions can be used for the refinement ... -
Sequence composition and environment effects on residue fluctuations in protein structures
(American Institute of Physics, 2010-10-15)Structure fluctuations in proteins affect a broad range of cell phenomena, including stability of proteins and their fragments, allosteric transitions, and energy transfer. This study presents a statistical-thermodynamic ... -
A Conserved Functional Domain of Drosophila Coracle Is Required for Localization at the Septate Junction and Has Membrane-organizing Activity
(Rockefeller University Press, 1998-03-23)The protein 4.1 superfamily is comprised of a diverse group of cytoplasmic proteins, many of which have been shown to associate with the plasma membrane via binding to specific transmembrane proteins. Coracle, a Drosophila ... -
Drosophila coracle, a Member of the Protein 4.1 Superfamily, Has Essential Structural Functions in the Septate Junctions and Developmental Functions in Embryonic and Adult Epithelial Cells
(American Society for Cell Biology, 1998-09-15)Although extensively studied biochemically, members of the Protein 4.1 superfamily have not been as well characterized genetically. Studies of coracle, a DrosophilaProtein 4.1 homologue, provide an opportunity to examine ... -
Bcl2:Beclin 1 complex: multiple mechanisms regulating autophagy/apoptosis toggle switch
(e-Century Publishing, 2012-02-28)Cancer cells have developed novel mechanisms for evading chemotherapy-induced apoptosis and autophagy-associated cell death pathways. Upon the discovery that chemotherapeutics could target these cell death pathways in a ... -
Tumor-targeted RNA-interference: functional non-viral nanovectors
(e-Century Publishing, 2010-10-05)While small interfering RNA (siRNA) and microRNA (miRNA) have attracted extensive attention and showed significant promise for the study, diagnosis and treatment of human cancers, delivering siRNA or miRNA specifically and ... -
Natural IAP inhibitor Embelin enhances therapeutic efficacy of ionizing radiation in prostate cancer
(e-Century Publishing, 2011-01-01)Embelin is an active ingredient of traditional herbal medicine that exhibits anti-tumor effects in human prostate cancer cells. However, therapeutic effect of embelin in combination with conventional radiation therapy is ... -
No small matter: microRNAs -- key regulators of cancer stem cells
(e-Century Publishing, 2010-02-05)Emerging evidence demonstrates that both tumor suppressor and oncogenic miRNAs play an essential role in stem cell self-renewal and differentiation by negatively regulating the expression of certain key genes in stem ... -
Overcoming cancer therapy resistance by targeting inhibitors of apoptosis proteins and nuclear factor-kappa B
(e-Century Publishing, 2008-10-25)Chemo- or radioresistance markedly impairs the efficacy of cancer therapy and involves anti-apoptotic signal transduction pathways that prevent cell death. In resistant cancer cells, both inhibitors of apoptosis proteins ... -
MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells
(Public Library of Science, 2009-08-28)Background MicroRNAs (miRNAs) have been implicated in cancer initiation and progression via their ability to affect expression of genes and proteins that regulate cell proliferation and/or cell death. Transcription of ... -
Self-Assembly of a Virus-Mimicking Nanostructure System for Efficient Tumor-Targeted Gene Delivery
(Mary Ann Liebert, 2002-02-10)Molecular therapy, including gene therapy, is a promising strategy for the treatment of human disease. However, delivery of molecular therapeutics efficiently and specifically to the target tissue remains a significant ... -
Transferrin-Liposome-Mediated Systemic p53 Gene Therapy in Combination with Radiation Results in Regression of Human Head and Neck Cancer Xenografts
(Mary Ann Liebert, 1999-12-10)The use of cationic liposomes as nonviral vehicles for the delivery of therapeutic molecules is becoming increasingly prevalent in the field of gene therapy. We have previously demonstrated that the use of the transferrin ... -
Substrate masking: binding of RNA by EGTA-inactivated micrococcal nuclease results in artifactual inhibition of RNA processing reactions
(Oxford University Press, 1991)Inhibition of an RNA processing reaction after treatment with the Ca2+- dependent micrococcal nuclease (MN) is often used as a criterion for the presence of a required RNA or ribonucleoproteln component in the system. ... -
Electronic fingerprinting of RNA
(Oxford University Press, 1988)Software has been developed to assist RNA fingerprinting analysis. One program generates, from a DNA sequence data file, the oligonucleotides resulting from digestion of an RNA transcript labeled with any specified ...