Pharmacy, School of: Recent submissions
Now showing items 381-400 of 417
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Evaluation of the role of P-glycoprotein in ivermectin uptake by primary cultures of bovine brain microvessel endothelial cells
(Springer Verlag, 1998)The P-glycoprotein efflux system located on the apical membrane of brain capillary endothelial cells functions as part of the blood-brain barrier. In this study, primary cultures of bovine brain microvessel endothelial ... -
Receptor-mediated angiotensin II transcytosis by brain mcrovessel endothelial cells
(Elsevier, 1998)ROSE, J. M. AND K. L. AUDUS. Receptor-mediated angiotensin II transcytosis by brain microvessel endothelial cells. PEPTIDES __( ) _____, 199_. - Angiotensin II (Ang II) uptake and transport across monolayers of bovine brain ... -
AT1 receptors mediate angiotensin II uptake and transport by brain microvessel endothelial cells in primary culture
(Lippincott Williams & Wilkins, 1999)The endothelial lining of the blood-brain barrier tightly controls the distribution of peptide hormones between the central nervous system and the circulation. Using primary cultures of brain microvessel endothelial cells, ... -
Drug disposition and targeting: Transport across the blood-brain barrier
(Springer Verlag, 1999) -
Transport mechanisms for the antidepressant citalopram in brain microvessel endothelium
(Elsevier, 1999)Blood-brain barrier transport of the selective serotonin reuptake inhibitor and antidepressant, citalopram, was studied using monolayers of bovine brain microvessel endothelial cells (BMECs). This study provides for the ... -
Overcoming the blood-brain barrier to taxane delivery for brain tumors and neurodegenerative diseases and brain tumors
(Springer Verlag, 2003)The blood-brain barrier (BBB) effectively prevents microtubule stabilizing drugs from readily entering the central nervous system (CNS). A major limiting factor for microtubule stabilizing drug permeation across the BBB ... -
Modulation of P-glycoprotein activity in Calu-3 cells using steroids and β-ligands
(Elsevier, 2001)The purpose of this work was to investigate if P-glycoprotein (Pgp) efflux pump activity could be inhibited in the sub-bronchial epithelial cell line, Calu-3, by glucocorticosteroids and β-ligands. The Pgp modulation ... -
Synthesis and Interactions of 7-Deoxy-, 10-Deacetoxy, and 10-Deacetoxy-7-Deoxypaclitaxel with NCI/ADR-RES Cancer Cells and Bovine Brain Microvessel Endothelial Cells
(Elsevier, 2006)7-Deoxypaclitaxel, 10-deacetoxypaclitaxel and 10-deacetoxy-7-deoxypaclitaxel were prepared and evaluated for their ability to promote assembly of tubulin into microtubules, their cytotoxicity against NCI/ADR-RES cells and ... -
Investigation of the metabolism of Substance-P at the blood-brain barrier using LC-MS/MS
(Elsevier, 2007)Substance P (SP) has been associated with pain, depression as well as neurodegenerative diseases. Many of these diverse actions of SP can potentially be attributed to SP metabolites generated at the blood-brain barrier ... -
The Presence of Inducible Cytochrome P450 Types 1A1 and 1A2 in the BeWo Cell Line
(Elsevier, 2003)The activity and inducibility of cytochrome P450 systems (CYP1A1:1A2) of the human placenta were assessed in a representative human trophoblast-like cell line, BeWo. The activity of CYP1A1 and CYP1A2 in microsome preparations ... -
Transport and Metabolism of Opioid Peptides across BeWo Cells, An In Vitro Model of the Placental Barrier
(Elsevier, 2002)In keeping with the advance of biotechnology, cell culture becomes an important tool for investigating the transport and the metabolism phenomena. A cell line of human origin, the BeWo choriocarcinoma cell line, was used ... -
AT1 receptors mediate angiotensin II uptake and transport by brain microvessel endothelial cells in primary culture
(Lippincott Williams & Wilkins, 1999-01) -
Computational Molecular Modeling Studies of the Interactions of Estrogens with Their Receptors and Intracellular Estrogen Binding Protein PDIp
(University of Kansas, 2010-09-27)The endogenous estrogens are vitally-important female sex hormones with diverse biological functions. Disruption of their actions contributes to the pathogenesis of a number of disease states in humans, such as endocrine ... -
STRUCTURAL REQUIREMENTS OF ORGANIC ANION TRANSPORTING POLYPEPTIDE MEDIATED TRANSPORT
(University of Kansas, 2010-04-12)The organic anion transporting polypeptides (human: OATP; other: Oatp) form a mammalian transporter superfamily that mediates the transport of structurally unrelated compounds across the cell membrane. Members in this ... -
Efflux transporters of the placenta
(Elsevier, 2003)The use of pharmaceuticals during pregnancy is often a necessity for the health of the mother. Until recently, the placenta was viewed as a passive organ through which molecules are passed indiscriminately between mother ... -
Nitric oxide and blood-brain barrier integrity
(Mary Ann Liebert, 2001)The blood-brain barrier (BBB) is comprised of the endothelial cells that line the capillaries of the brain. The unique characteristics of this barrier include tight intercellular junctions, a complex glycocalyx, a paucity ... -
Cultured Brain Microvessel Endothelial Cells as In Vitro Models of the Blood-Brain Barrier
(National Institutes of Health, 1992) -
Adsorptive endocytosis and membrane recycling by cultured primary bovine brain microvessel endothelial cell monolayers
(Company of Biologists, 1990)The dynamics of membrane recycling were examined in primary cultures of brain microvessel endothelial cells (BMECs). Because the BMEC surface was dominated by galactosylated glycoconjugates, ricin agglutinin (RCAI) was ... -
DEVELOPMENTAL REGULATION OF THE DRUG-PROCESSING GENOME IN MOUSE LIVER
(University of Kansas, 2010-07-29)Despite the recent progress in understanding the expression patterns and regulatory mechanisms of drug-processing genes, namely phase-I and -II drug metabolizing enzymes and transporters in adults, very little is known of ...