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    Receptor-mediated angiotensin II transcytosis by brain mcrovessel endothelial cells

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    Audus_AFD_Rose Audus Peptides 1998.pdf (209.6Kb)
    Issue Date
    1998
    Author
    Rose, Jayna M.
    Audus, Kenneth L.
    Publisher
    Elsevier
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
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    Abstract
    ROSE, J. M. AND K. L. AUDUS. Receptor-mediated angiotensin II transcytosis by brain microvessel endothelial cells. PEPTIDES __( ) _____, 199_. - Angiotensin II (Ang II) uptake and transport across monolayers of bovine brain microvessel endothelial cells (BMECs) was demonstrated. Ang II transport was linear up to 2 hours, saturable with a Km of 1.7 nM, and tended to be polarized with the apical-to-basolateral transport being greater. [3H]-Ang II transport was found to be inhibited by excess unlabeled Ang II, by the Ang II analog sarathrin, and by the endocytic inhibitor phenylarsine oxide. Ang II-(2-8) and -(3-8) were shown to significantly increase the transport of Ang II. These results demonstrate for the first time the receptor-mediated transcytosis of Ang II across brain microvessel endothelium.
    URI
    http://hdl.handle.net/1808/7492
    DOI
    https://doi.org/10.1016/S0196-9781(98)00054-0
    Collections
    • Pharmacy Scholarly Works [286]
    Citation
    Rose, J.M. and Audus, K.L. (1998) Receptor-mediated angiotensin II transcytosis by brain mcrovessel endothelial cells. Peptides 19, 1023-1030. PMID: 9700750 http://dx.doi.org/10.1016/S0196-9781(98)00054-0

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    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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