Pharmacy, School of: Recent submissions
Now showing items 361-380 of 417
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Action of Pyrroloquinolinequinol As an Antioxidant Against Lipid Peroxidation in Solution
(Mary Ann Liebert, 1999)The activities of pyrroloquinoline quinone (PQQ), a coenzyme of methanol dehydrogenase and amine oxidase, and its reduced form pyrroloquinoline quinol (PQQH2 ) as an antioxidant have been measured in solution. PQQH2 was ... -
Differential Effects of HIF-1 Inhibition by YC-1 on the Overall Outcome and Blood-Brain Barrier Damage in a Rat Model of Ischemic Stroke
(Public Library of Science, 2011-11-16)Hypoxia-inducible factor 1 (HIF-1) is a master regulator of cellular adaptation to hypoxia and has been suggested as a potent therapeutic target in cerebral ischemia. Here we show in an ischemic stroke model of rats that ... -
Hepcidin Is Involved in Iron Regulation in the Ischemic Brain
(Public Library of Science, 2011-09-21)Oxidative stress plays an important role in neuronal injuries caused by cerebral ischemia. It is well established that free iron increases significantly during ischemia and is responsible for oxidative damage in the brain. ... -
THE ROLE OF EPIGENETICS IN TRANSCRIPTIONAL REGULATION OF FXR AND SILENCING FXR EXPRESSION IN HUMAN COLON CANCER
(University of Kansas, 2011-08-31)Farnesoid X receptor (FXR) is a ligand activated transcription factor belonging to the nuclear receptor superfamily and bile acids are its endogenous ligands. FXR is a critical regulator of the enterohepatic circulation ... -
CHARACTERIZATION OF ORGANIC ANION TRANSPORTING POLYPEPTIDE 1A1 (OATP1A1) IN THE BILE ACID HOMEOSTASIS OF MICE
(University of Kansas, 2011-04-20)Organic anion transporting polypeptides (human: OATPs; all other species: Oatps; gene symbol: SLCO/Slco) are sodium-independent transport systems that mediate the transmembrane transport of a wide range of amphipathic ... -
SEX STEROIDS MODULATE NOCICEPTION, AND ESTROGEN MODIFIES SUPRASPINAL NOCICEPTIVE ACTIVATION
(University of Kansas, 2010-12-10)Chronic pain leads neurological disorders in the US both in terms of numbers of cases and economic cost. The understanding of sex differences in the sensory experience of pain is emerging. For example, the incidence of ... -
NEW APPROACHES IN UNDERSTANDING DRUG METABOLISM
(University of Kansas, 2011-02-22)Limitations in technology, such as DNA sequencing and appropriate model systems, have made it difficult to understand the genetic and non-genetic factors that influence the liver's role in metabolizing drugs. New approaches ... -
Mechanisms of Proinflammatory Signaling during Cholestasis
(University of Kansas, 2011-04-11)Cholestasis is a condition in which bile flow from the liver to the intestines is inhibited. Loss of bile flow leads to increased concentrations of bile constituents, including bilirubin and bile acids within the liver. ... -
EFFECT OF BILE ACID FEEDING AND SEQUESTRATION ON LIVER BILE ACID COMPOSITION AND GENE REGULATION IN MICE
(University of Kansas, 2010-12-16)The dissertation investigates the non-hepatotoxic doses of five bile acids (BAs) in the feed of mice, as well as adaptations in the expression of genes involved in BA homeostasis and the possible roles of FXR-mediated ... -
Molecular Mechanism of Polybrominated Diphenyl Ether Disposition in the Liver
(University of Kansas, 2010-10-01)Polybrominated diphenyl ethers (PBDEs) were introduced in the late 1970's as additive flame retardants incorporated into textiles, electronics, plastics and furniture. Although 2,2',3,3',4,4',5,5',6,6'-decabromodiphenyl ... -
Tetrazole compounds: The effect of structure and pH on Caco-2 cell permeability
(Wiley-Liss, 2006)A tetrazole ring is often used in drug discovery as a replacement for the carboxylic acid group. Previous work indicates that compounds containing a tetrazole moiety show asymmetric permeability in Caco-2 cells characteristic ... -
Multidrug resistance-associated protein (MRP) isoforms and the breast cancer resistance protein (BCRP) mediate sulfate conjugate efflux out of BeWo cells
(Elsevier, 2010)The breast cancer resistance protein (BCRP) and the multidrug resistance-associated proteins (MRPs) have the ability to eliminate sulfate conjugates but it is not known if this constitutes one of their roles in the placenta. ... -
Controlling drug delivery across the placenta: A commentary
(Elsevier, 1999)A challenge in modern drug therapy is to develop strategies for safer and more selective targeting of drug delivery in pregnancy. Specifically, approaches are needed that would restrict unnecessary drug exposure to either ... -
Characterization of Dextromethorphan And Dextrorphan Uptake by a Putative Glutamic Acid Carrier and Passive Diffusion Across Brain Microvessel Endothelium
(Informa Healthcare, 1993)The mechanisms of uptake and transcellular passage of dextromethorphan (DM) and its major metabolite dextrorphan (DX) across the endothelial component of the blood–brain barrier have been investigated with primary cultures ... -
Effect of Bisphenol A on Drug Efflux in BeWo, a Human Trophoblast-like Cell Line
(Elsevier, 2005)Bisphenol A (BPA) is a monomer of polycarbonate plastics that has estrogenic activities and has been shown to be a substrate for multidrug resistant efflux mechanisms, specifically, P-glycoprotein. Since the natural hormone ... -
21-aminosteroid and 2-(aminomethyl)chromans inhibition of arachidonic acid-induced lipid peroxidation and permeability enhancement in bovine brain microvessel endothelial cell monolayers
(Elsevier, 1995-09)Selected 21-aminosteroids (U74500A, U74006F, and U74389G) and a 2-(aminomethyl)chromans (U78517F) were tested for their efficacy in preventing arachidonate-induced lipid peroxidation and permeability alterations in brain ... -
Functional expression of P-glycoprotein in primary cultures of human cytotrophoblasts and BeWo cells
(Elsevier, 2000)The objective of this study was to investigate the functional expression of the efflux transporter, P-glycoprotein (P-gp), in primary cultures of human cytotrophoblasts and BeWo cell monolayers. Uptake studies with primary ... -
Carrier-mediated transport of monocarboxylic acids in BeWo cell monolayers as a model of the human trophoblast
(John Wiley & Sons, 1999)The monolayer-forming, human choriocarcinoma cell line, BeWo, was used to study the mechanisms of monocarboxylic acid transport across the human trophoblast. Benzoic acid, acetic acid, and lactic acid were used as markers ... -
Carrier-mediated transport of valproic acid in BeWo cells, a human trophoblast cell line
(Elsevier, 2000)The biochemical mechanisms mediating the rapid distribution of valproic acid across placenta are not precisely known. We have characterized valproic acid transport by the human trophoblast using the human choriocarcinoma ... -
Paclitaxel Succinate Analogs: Anionic Introduction as a Strategy to Impart Blood Brain Barrier Permeability
(Elsevier, 2008)A focused library of TX-67 (C10 hemi-succinate) analogs have been prepared including regioisomeric, functional group, and one-carbon homologs. These were prepared to investigate TX-67’s lack of interaction with P-glycoprotein ...