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    Computational Molecular Modeling Studies of the Interactions of Estrogens with Their Receptors and Intracellular Estrogen Binding Protein PDIp

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    Wang_ku_0099D_11163_DATA_1.pdf (3.571Mb)
    Issue Date
    2010-09-27
    Author
    Wang, Pan
    Publisher
    University of Kansas
    Format
    199 pages
    Type
    Dissertation
    Degree Level
    Ph.D.
    Discipline
    Pharmacology, Toxicology & Therapeutics
    Rights
    This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
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    Abstract
    The endogenous estrogens are vitally-important female sex hormones with diverse biological functions. Disruption of their actions contributes to the pathogenesis of a number of disease states in humans, such as endocrine disruption, infertility, and development of cancers. My dissertation research sought to explore the potential usefulness of computational molecular modeling tools in studying the interactions of various estrogen derivatives (e.g., endogenous estrogen metabolites, non-aromatic steroids, and synthetic antiestrogens) with human ERs as well as a recently-identified intracellular estrogen-binding protein. The results of my dissertation projects offer important insights into the three-dimensional structural characteristics of the binding interactions of various estrogen analogs with the human ERs and PDIp. These studies provide a platform for the future development of an automated docking-based computational approach that can screen numerous environmental compounds for their potential ability to bind to human ERs as well as other estrogen binding proteins in the body.
    URI
    http://hdl.handle.net/1808/7432
    Collections
    • Dissertations [3958]
    • Pharmacy Dissertations and Theses [70]

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    KU Libraries
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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