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    Efflux transporters of the placenta

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    Audus Efflux Transporters author final.pdf (435.8Kb)
    Issue Date
    2003
    Author
    Young, Amber M.
    Allen, Courtni E.
    Audus, Kenneth L.
    Publisher
    Elsevier
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Metadata
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    Abstract
    The use of pharmaceuticals during pregnancy is often a necessity for the health of the mother. Until recently, the placenta was viewed as a passive organ through which molecules are passed indiscriminately between mother and fetus. In reality, the placenta contains a plethora of transporters, some of which appear to be specifically dedicated to removal of xenobiotics and toxic endogenous compounds. Drug efflux transporters such as P-glycoprotein (P-gp), several multidrug resistant associated proteins (MRPs) and breast cancer resistant protein (BCRP) may provide mechanisms that protect the developing fetus. Bile acid transporters may also play a role in exporting compounds back into the maternal compartment. Steroid hormones directly influence the level of expression and function in some of these transporters. Investigating the link between the hormones of pregnancy and these drug efflux transporters is one possible key in developing strategies to deliver drugs to the mother with minimal fetal risk.
    Description
    This is the author's accepted manuscript, post peer review. For the published version, please see the link in this record.
    URI
    http://hdl.handle.net/1808/7380
    DOI
    https://doi.org/10.1016/S0169-409X(02)00174-6
    Collections
    • Pharmacy Scholarly Works [286]
    Citation
    Young, A.M., Allen, C.E., and Audus, K.L.* (2003) Efflux transporters of the placenta. Advanced Drug Delivery Reviews 55, 125-132. PMID: 12535577

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    KU Libraries
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    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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