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    Synthesis and Interactions of 7-Deoxy-, 10-Deacetoxy, and 10-Deacetoxy-7-Deoxypaclitaxel with NCI/ADR-RES Cancer Cells and Bovine Brain Microvessel Endothelial Cells

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    Audus_AFD_Ge et al BMCL 2006.pdf (107.2Kb)
    Issue Date
    2006
    Author
    Ge, Haibo
    Vasandani, Veena
    Huff, Jacquelyn K.
    Audus, Kenneth L.
    Himes, Richard H.
    Seelig, Anna
    Georg, Gunda I.
    Publisher
    Elsevier
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Metadata
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    Abstract
    7-Deoxypaclitaxel, 10-deacetoxypaclitaxel and 10-deacetoxy-7-deoxypaclitaxel were prepared and evaluated for their ability to promote assembly of tubulin into microtubules, their cytotoxicity against NCI/ADR-RES cells and for their interactions with Pglycoprotein in bovine brain microvessel endothelial cells. The three compounds were essentially equivalent to paclitaxel in cytotoxicity against NCI/ADR-RES cells. They also appeared to interact with P-glycoprotein in the endothelial cells with the two 10-deacetoxy compounds having less interaction than paclitaxel and 7-deoxypaclitaxel. ©2000 Elsevier Science Ltd. All rights reserved.
    Description
    Please note that this is an author-produced PDF of an article accepted for publication following peer review. The publisher version is available on its site.
    URI
    http://hdl.handle.net/1808/7486
    DOI
    https://doi.org/10.1016/j.bmcl.2005.09.043
    Collections
    • Pharmacy Scholarly Works [286]
    Citation
    Ge, H., Vasandani, V., Huff, J.K., Audus, K.L., Himes, R.H., Seelig, A., and Georg, G.I. (2006) Synthesis and interactions of 7-deoxy-, 10-deacetoxy and 7,10-dideoxypaclitaxel with MCF7-ADR cancer cells and bovine brain microvessel endothelial cells. Bioorg. Med. Chem. Lett., 16, 433-436. PMID: 16271474 http://dx.doi.org/10.1016/j.bmcl.2005.09.043

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    KU Libraries
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    KU Libraries
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    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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