Pharmacy, School of: Recent submissions
Now showing items 401-417 of 417
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MECHANISMS OF MITOCHONDRIA-MEDIATED APOPTOSIS INDUCED BY CYTOTOXIC STRESS
(University of Kansas, 2010-06-04)Defects within the apoptotic pathway are thought to contribute to tumorigenesis and therapeutic resistance. Although most cytotoxic anti-cancer drugs are thought to activate the mitochondria-mediated apoptotic pathway, the ... -
SEX DIFFERENCES IN GENE EXPRESSION AND PAIN-RELATED BEHAVIORS IN A PRECLINICAL MODEL OF MIGRAINE
(University of Kansas, 2010-06-01)Many laboratory animal studies of migraine have employed electrophysiological techniques to assess neuronal sensitization, but few have examined behaviors using International Headache Society criteria, which are based on ... -
MODULATION OF COX I AND COX II-MEDIATED FORMATION OF VARIOUS ARACHIDONIC ACID METABOLITES IN VITRO AND IN VIVO BY DIETARY POLYPHENOLS
(University of Kansas, 2009-12-03)Cyclooxygenase (COX) is a key enzyme required for the conversion of arachidonic acid (AA) to various prostaglandins (PGs), thromboxanes (TXs), and hydroxyeicosatetraenoic acids (HETEs), by which AA exert numerous biological ... -
PROTECTIVE STRATEGIES AGAINST ACETAMINOPHEN INDUCED HEPATOTOXICITY
(University of Kansas, 2010-01-07)Acetaminophen (APAP) is a widely used analgesic, which is safe at therapeutic levels. APAP is mainly conjugated with glucuronic acid and sulfate to form water-soluble, nontoxic metabolites. Only a small portion of APAP is ... -
Methionine Sulfoxide Reductase in Neurodegenerative Disease and Locomotor-Associated Dopamine Signaling
(University of Kansas, 2010-04-28)Reactive oxygen species can cause posttranslational modifications to amino acids, including sulfur-containing methionine. Methionine sulfoxide modifications are reduced by methionine sulfoxide reductase enzymes. The redox ... -
Development and validation of transgene constructs in order to generate bi-transgenic mice models for Diabetic Peripheral Neuropathy research
(University of Kansas, 2010-04-09)Diabetic peripheral neuropathy (DPN), a common complication of diabetes, involves nerve damage in the arms and legs. Segmental demyelination is one of the basic patterns observed in the pathology of DPN. Demyelinating ... -
Regulation of the Pregnane X Receptor Signaling Pathway
(University of Kansas, 2009-04-23)Liver-enriched nuclear receptors (NRs) collectively function as metabolic and toxicological `sensors' that mediate liver-specific gene-activation in mammals. NR-mediated gene-environment interaction regulates important ... -
NEW INSIGHTS INTO THE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION DURING APOPTOSIS
(University of Kansas, 2009-08-12)Disruption of normal apoptosis can contribute to the onset of cancer. Additionally, many cancer drugs are effective for their ability to initiate the apoptotic process. Often this involves the activation of the ... -
RETINOID-INDUCED APOPTOSIS AND PROLIFERATION OF HEPATOCYTES ARE MEDIATED BY DISTINCT NUCLEAR RECEPTORS
(University of Kansas, 2009-04-07)Retinoids, derivatives of vitamin A, are important signaling molecules regulating cellular homeostasis including differentiation, apoptosis, and proliferation. In this dissertation, we examined the versatile effects of ... -
Novel Role of the JAK-STAT Pathway in Mediating the Effects of Atypical Antipsychotics on 5-HT2A Receptor Signaling
(University of Kansas, 2008-05-06)The therapeutic benefits of atypical antipsychotics are proposed to be mediated by antagonism and subsequent desensitization of 5-HT2A receptor signaling; however, the mechanisms underlying this desensitization response ... -
Identification and Biochemical Characterization of PGC-1beta-Interacting Proteins
(University of Kansas, 2008-01-01)Nuclear receptors (NRs) are ligand-activated transcription factors. They regulate key biological processes including homeostasis of lipophilic molecules, organogenesis, development, and reproduction. The ability of NRs to ... -
Disruption of Orolingual Behavior in Rats Treated with Atypical Antipsychotic Drugs
(University of Kansas, 2008-01-01)The atypical antipsychotics are a group of second generation drugs used for the treatment of schizophrenia, schizoaffective disorder, as well as some forms of bipolar and major depressive disorder. First generation or the ... -
PHARMACOLOGIC AND TRANSGENIC ACTIVATION OF NUCLEAR FACTOR-ERYTHROID 2-RELATED FACTOR 2 (NRF2) ALTERS KINETICS AND TOXICODYNAMICS OF XENOBIOTICS
(University of Kansas, 2008-01-01)Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor, which, upon translocation into the nucleus, is capable of inducing a variety of cytoprotective genes, such as NAD(P)H:quinone oxidoreductase 1 ... -
Hyperglycemia Increases Mitochondrial Protein Expression in the Absence of Oxidative Stress
(University of Kansas, 2008-01-01)Long-term diabetes may cause diabetic peripheral neuropathy (DPN). Hyperglycemic-induced oxidative stress is widely accepted as the contributing factor in the development of diabetic complications. The mitochondrion has ... -
A REVIEW OF NUCLEAR RECEPTOR GENE ACTIVATION THROUGH COFACTOR PROTEIN INTERACTIONS
(University of Kansas, 2008-07-07)Humans are faced with a vast number of pathological conditions. Some the most prevalent and deadly disease states include cancer, obesity, and diabetes. A large amount of scientific research and development has gone into ... -
AURORA KINASES IN SOLELY ESTROGEN-INDUCED ONCOGENESIS: RELATION TO CENTROSOME AMPLIFICATION AND CHROMOSOMAL INSTABILITY
(University of Kansas, 2008-06-02)Estrogens play a crucial role in the causation and development of sporadic breast cancer, which accounts for ~ 90 - 95% of all breast cancer cases. To understand the molecular and cellular events involved in solely ... -
Mechanisms of Cutaneous Wound Healing are Mediated via Peripheral Neuropeptide Activity
(University of Kansas, 2008-07-16)Topically applied morphine is routinely used to alleviate pain in cutaneous wounds such as burns and pressure sores, yet evidence suggests the topical administration of exogenous opioid drugs may impair wound closure. This ...