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    Ultrastructural localization of the high molecular weight proteins associated with in vitro-assembled brain microtubules

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    Dentler_April1-1975.pdf (1.131Mb)
    Issue Date
    1975-04-01
    Author
    Dentler, William L., Jr
    Granett, S.
    Rosenbaum, J. L.
    Publisher
    Rockefeller University Press
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
    Metadata
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    Abstract
    Microtubules isolated from brain extracts by in vitro assembly (1, 19, 23) are composed principally of two tubulins and two high molecular weight proteins (microtubule-associated proteins [MAPS] 1 and 2) (2,5,7,20). Recently, it was demonstrated that in vitro-assembled brain microtubules (neurotubules) are coated with filaments (5, 7) which are similar to the filaments attached to neurotubules in situ (4, 15, 21, 24, 25), and it was suggested that the filaments are composed of the higher molecular weight MAPs (5, 7, 12). In this study, microtubules were assembled in the presence and absence of the MAPs, and thin sections of the microtubules were examined by electron microscopy. The results show that the filaments only occur on microtubules assembled in the presence of the MAPs and it is therefore concluded that the filaments are composed of the high molecular weight MAP's.
    Description
    This is the publisher's version, also available electronically from http://jcb.rupress.org/content/65/1/237.
    URI
    http://hdl.handle.net/1808/17004
    DOI
    https://doi.org/10.1083/jcb.65.1.237
    ISSN
    0021-9525
    Collections
    • Molecular Biosciences Scholarly Works [458]
    Citation
    Dentler, William L.; Granett, S.; Rosenbaum, J. L. (1975). "Ultrastructural localization of the high molecular weight proteins associated with in vitro-assembled brain microtubules." Journal of Cell Biology, 65(1):237-241. http://www.dx.doi.org/10.1083/jcb.65.1.237.

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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