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Molecular Biosciences: Recent submissions
Now showing items 621-640 of 887
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T cell receptor alpha-chain gene rearrangements in B-precursor leukemia are in contrast to the findings in T cell acute lymphoblastic leukemia. Comparative study of T cell receptor gene rearrangement in childhood leukemia.
(The American Society for Clinical Investigation, 1987-12)We have analyzed T cell receptor alpha-chain gene configuration using three genomic joining (J) region probes in 64 children with acute lymphoblastic leukemia (ALL). 11 out of 18 T-ALLs were T3 positive; alpha-chain gene ... -
Comparison of T cell receptor alpha, beta, and gamma gene rearrangement and expression in T cell acute lymphoblastic leukemia.
(The American Society for Clinical Investigation, 1988-04)We have analyzed the configuration of the T cell receptor (TCR) alpha gene using newly developed genomic joining region (J alpha) probes, which cover approximately 80 kb of the J alpha region upstream from the constant ... -
Rearrangement of Variable Region T Cell Receptor y Genes in Acute Lymphoblastic Leukemia Vy Gene Usage Differs in Mature and Immature T Cells
(The American Society for Clinical Investigation, 1989-04-01)Using probes recognizing variable regions (V gamma) and joining regions (J gamma) of the T cell receptor (TCR) gamma gene, we have analyzed the usage of V gamma genes in 24 patients with T cell acute lymphoblastic leukemia ... -
An ABC Transporter Is Required for Secretion of Peptide Sex Pheromones in Enterococcus faecalis
(The American Society for Microbiology, 2014-09-23)Enterococci are leading causes of hospital-acquired infection in the United States and continue to develop resistances to new antibiotics. Many Enterococcus faecalis isolates harbor pheromone-responsive plasmids that mediate ... -
Interaction between Tumor Suppressor Adenomatous Polyposis Coli and Topoisomerase IIα: Implication for the G2/M Transition
(American Society for Cell Biology, 2008-10-01)The tumor suppressor adenomatous polyposis coli (APC) is implicated in regulating multiple stages of the cell cycle. APC participation in G1/S is attributed to its recognized role in Wnt signaling. APC function in the G2/M ... -
SUSP1 antagonizes formation of highly SUMO2/3-conjugated species
(The Rockefeller University Press, 2006-09-21)Small ubiquitin-related modifier (SUMO) processing and deconjugation are mediated by sentrin-specific proteases/ubiquitin-like proteases (SENP/Ulps). We show that SUMO-specific protease 1 (SUSP1), a mammalian SENP/Ulp, ... -
SUMO-2/3 regulates topoisomerase II in mitosis
(The Rockefeller University Press, 2003-11-03)We have analyzed the abundance of SUMO-conjugated species during the cell cycle in Xenopus egg extracts. The predominant SUMO conjugation products associated with mitotic chromosomes arose from SUMO conjugation of topoisomerase ... -
Ewing Sarcoma Protein Ewsr1 Maintains Mitotic Integrity and Proneural Cell Survival in the Zebrafish Embryo
(Public Library of Science, 2007-10-03)Background The Ewing sarcoma breakpoint region 1 gene (EWSR1), also known as EWS, is fused to a number of different partner genes as a result of chromosomal translocation in diverse sarcomas. Despite the involvement of ... -
Tomosyn Inhibits Synaptic Vesicle Priming in Caenorhabditis elegans
(Public Library of Science, 2006-07-25)Caenorhabditis elegans TOM-1 is orthologous to vertebrate tomosyn, a cytosolic syntaxin-binding protein implicated in the modulation of both constitutive and regulated exocytosis. To investigate how TOM-1 regulates exocytosis ... -
Standardized Assessment of Concussion in football players
(American Academy of Neurology, 1997-01-01)Article abstract-The recent formulation of guidelines for the management of concussion in sports adopted by the American Academy of Neurology specifically calls for the development of a standardized, systematic sideline ... -
The NC1/Endostatin Domain of Caenorhabditis elegans Type XVIII Collagen Affects Cell Migration and Axon Guidance
(The Rockefeller University Press, 2001-03-19)Type XVIII collagen is a homotrimeric basement membrane molecule of unknown function, whose COOH-terminal NC1 domain contains endostatin (ES), a potent antiangiogenic agent. The Caenorhabditis elegans collagen XVIII ... -
Oligomerization-dependent Regulation of Motility and Morphogenesis by the Collagen XVIII NC1/Endostatin Domain
(The Rockefeller University Press, 2001-03-19)Collagen XVIII (c18) is a triple helical endothelial/epithelial basement membrane protein whose noncollagenous (NC)1 region trimerizes a COOH-terminal endostatin (ES) domain conserved in vertebrates, Caenorhabditis elegans ... -
A Smac-mimetic sensitizes prostrate cancer cells to TRAIL-induced apoptosis via modulating IAPs and NF-kappaB
(BioMed Central, 2009-11-06)Background: Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising agent for human cancer therapy, prostate cancer still remains resistant to TRAIL. Both X-linked inhibitor of apoptosis ... -
Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres
(BioMed Central, 2008-09-21)Background: MicroRNAs (miRNAs), some of which function as oncogenes or tumor suppressor genes, are involved in carcinogenesis via regulating cell proliferation and/or cell death. MicroRNA miR-34 was recently found to be a ... -
A low-cost open-source SNP genotyping platform for association mapping applications
(BioMed Central, 2005-12-02)Association mapping aimed at identifying DNA polymorphisms that contribute to variation in complex traits entails genotyping a large number of single-nucleotide polymorphisms (SNPs) in a very large panel of individuals. ... -
Fine scale structural variants distinguish the genomes of Drosophilia melanogaster and D. pseudoobscura
(BioMed Central, 2006-07-07)Background: A primary objective of comparative genomics is to identify genomic elements of functional significance that contribute to phenotypic diversity. Complex changes in genome structure (insertions, duplications, r ... -
Intracellular lumen extension requires ERM-1-dependent apical membrane expansion and AQP-8-mediated flux
(Nature Publishing Group, 2013-02-01)Many unicellular tubes such as capillaries form lumens intracellularly, a process that is not well understood. Here we show that the cortical membrane organizer ERM-1 is required to expand the intracellular apical/lumenal ... -
HSV-1 ICP0: An E3 Ubiquitin Ligase That Counteracts Host Intrinsic and Innate Immunity
(MDPI, 2014-05-20)The herpes simplex virus type 1 (HSV-1) encoded E3 ubiquitin ligase, infected cell protein 0 (ICP0), is required for efficient lytic viral replication and regulates the switch between the lytic and latent states of HSV-1. ... -
MECHANISM AND FUNCTION OF SPLICEOSOMAL CLEAVAGE IN FISSION YEAST
(University of Kansas, 2013-08-31)Telomerase is the ribonucleoprotein complex that replenishes lost DNA sequences at the ends of chromosomes. At its core, telomerase consists of an RNA subunit (TERC) that provides the template and a catalytic protein ... -
Nova Mediates Experience Dependent Processing of Orb2A mRNA
(University of Kansas, 2013-08-31)Memory serves the vital function of associating disparate stimuli to modify future behavior for fitness. For instance, Drosophila melanogaster can learn to associate neutral odors with sweet metabolically available sugars ...