Formal [4+3] Epoxide Cascade Reaction via a Complementary Ambiphilic Pairing Strategy

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Issue Date
2010-03-19Author
Rolfe, Alan
Samarakoon, Thiwanka Bandara
Hanson, Paul R.
Publisher
American Chemical Society
Type
Article
Article Version
Scholarly/refereed, author accepted manuscript
Rights
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/ol100035e
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Show full item recordAbstract
A formal [4+3] epoxide cascade protocol utilizing ambiphilic sulfonamides and a variety of epoxides (masked ambiphiles) has been developed for the generation of benzothiaoxazepine-1,1′-dioxides and oxathiazepine-1,1′-dioxides. This protocol combines an epoxide ring-opening with either an SNAr or oxa-Michael cyclization pathway.
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Citation
Rolfe, A., Samarakoon, T. B., & Hanson, P. R. (2010). Formal [4+3] Epoxide Cascade Reaction via a Complementary Ambiphilic Pairing Strategy. Organic Letters, 12(6), 1216–1219. http://doi.org/10.1021/ol100035e
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