A formal [4+3] epoxide cascade protocol utilizing ambiphilic sulfonamides and a variety of epoxides (masked ambiphiles) has been developed for the generation of benzothiaoxazepine-1,1′-dioxides and oxathiazepine-1,1′-dioxides. This protocol combines an epoxide ring-opening with either an SNAr or oxa-Michael cyclization pathway.
Rolfe, A., Samarakoon, T. B., & Hanson, P. R. (2010). Formal [4+3] Epoxide Cascade Reaction via a Complementary Ambiphilic Pairing Strategy. Organic Letters, 12(6), 1216–1219. http://doi.org/10.1021/ol100035e
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