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Chemistry: Recent submissions
Now showing items 361-380 of 964
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Optimism and Physical Health: A Meta-analytic Review
(Springer Verlag, 2009-06)Background—Prior research links optimism to physical health, but the strength of the association has not been systematically evaluated. Purpose—The purpose of this study is to conduct a meta-analytic review to determine ... -
Deacylative allylation of nitroalkanes: unsymmetric bisallylation via 3-component coupling
(Wiley, 2011-02-11)Use it and lose it! Allylic alcohols were used directly for the synthesis of diallylated nitroalkanes in a three-component coupling based on the strategy of deacylative allylation for the in situ generation of a nucleophile ... -
1,3-Allylic Strain as a Strategic Diversification Element For Constructing Libraries of Substituted 2-Arylpiperidines
(Wiley, 2011-03-14)Flipping diversity—Minimization of 1,3-allylic strain is a recurring element in the design of a stereochemically- and spatially-diverse collection of 2-arylpiperidines. Here, stereochemicallydiverse scaffolding is first ... -
Separation and Detection of Peroxynitrite Using Microchip Electrophoresis with Amperometric Detection
(American Chemical Society, 2010-03-01)Peroxynitrite (ONOO-) is a highly reactive species implicated in the pathology of several cardiovascular and neurodegenerative diseases. It is generated in vivo by the diffusion-limited reaction of nitric oxide (NO•) and ... -
GlycoPep Grader: A web-based utility for assigning the composition of N-linked glycopeptides
(American Chemical Society, 2012-06-05)GlycoPep Grader (GPG) is a freely-available software tool designed to accelerate the process of accurately determining glycopeptide composition from tandem mass spectrometric data. GPG relies on the identification of unique ... -
GlycoPep Detector: A tool for assigning mass spectrometry data of N-linked glycopeptides based on their ETD spectra
(American Chemical Society, 2013-05-21)Electron transfer dissociation (ETD) is commonly used in fragmenting N-linked glycopeptides in their mass spectral analyses to complement collision induced dissociation (CID) experiments. The glycan remains intact through ... -
Characterizing O-linked glycopeptides by electron transfer dissociation: fragmentation rules and applications in data analysis
(American Chemical Society, 2013-08-22)Studying protein O-glycosylation remains an analytical challenge. Different from N-linked glycans, the O-glycosylation site is not within a known consensus sequence. Additionally, O-glycans are heterogeneous with numerous ... -
An Integrated Microfluidic Device for Monitoring Changes in Nitric Oxide Production in Single T-Lymphocyte (Jurkat) Cells
(American Chemical Society, 2013-11-05)A considerable amount of attention has been focused on the analysis of single cells in an effort to better understand cell heterogeneity in cancer and neurodegenerative diseases. Although microfluidic devices have several ... -
Multicapillary Flow Reactor: Synthesis of 1,2,5-Thiadiazepane 1,1-Dioxide Library Utilizing One-Pot Elimination and Inter-/Intramolecular Double aza-Michael Addition Via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS)
(Akadémiai Kiadó, 2012-12)A microwave-assisted, continuous-flow organic synthesis (MACOS) protocol for the synthesis of functionalized 1,2,5-thiadiazepane 1,1-dioxide library, utilizing a one-pot elimination and inter-/intramolecular double aza-Michael ... -
Accessing Stereochemically Rich Sultams via Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS) Scale-out
(Akadémiai Kiadó, 2011-08)The generation of stereochemically-rich benzothiaoxazepine-1,1′-dioxides for enrichment of high-throughput screening collections is reported. Utilizing a microwave-assisted, continuous flow organic synthesis platform ... -
A Simple Approach to Assign Disulfide Connectivity Using Extracted Ion Chromatograms of Electron Transfer Dissociation Spectra
(American Chemistry Society, 2013-01-03)Increasing interest in production of protein-based pharmaceuticals (biotherapeutics) is accompanied by an increased need for verification of protein folding and correct disulfide bonding. Recombinant protein expression may ... -
A general protease digestion procedure for optimal protein sequence coverage and PTM analysis of recombinant glycoproteins: Application to the characterization of hLOXL2 glycosylation
(American Chemistry Society, 2011-10-27)Using recombinant DNA technology for expression of protein therapeutics is a maturing field of pharmaceutical research and development. As recombinant proteins are increasingly utilized as biotherapeutics, improved ... -
Microchip electrophoresis with amperometric detection for the study of the generation of nitric oxide by NONOate salts
(Springer Verlag, 2012-03-14)Microchip electrophoresis (ME) with electrochemical detection was used to monitor nitric oxide (NO) production from diethylammonium (Z)-1-(N,N-diethylamino)diazen-1-ium-1,2-diolate (DEA/NO) and 1-(hydroxyl-NNO-azoxy)-L-proline ... -
Optimization of the Separation of NDA-Derivatized Methylarginines by Capillary and Microchip Electrophoresis
(SAGE Publications, 2012-02-17)The methylated arginines (MAs) monomethylarginine (MMA), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) have been shown to be independent predictors of cardiovascular disease. This article describes ... -
Reaction Landscape of a Pentadentate N5-Ligated MnII Complex with O2•− and H2O2 Includes Conversion of a Peroxomanganese(III) Adduct to a Bis(μ-oxo)dimanganese(III,IV) Species
(Royal Society of Chemistry, 2013-07-19)Herein we describe the chemical reactivity of the mononuclear [MnII(N4py)(OTf)](OTf) (1) complex with hydrogen peroxide and superoxide. Treatment of 1 with one equivalent superoxide at −40 °C in MeCN formed the ... -
Ultrathin Gold Nanowire-Functionalized Carbon Nanotubes for Hybrid Molecular Sensing
(ACS Nano, 2013-09-03)Carbon nanotubes (CNTs) have shown great potential as sensing component in the electrochemical, field effect transistor and optical sensors, because of their extraordinary onedimensional electronic structure, thermal ... -
The Power of Solvent in Altering the Course of Photorearrangements
(American Chemical Society, 2011-02-18)A clean bifurcation between two important photochemical reactions through competition of a triplet state Type II H-abstraction reaction with a photo-Favorskii rearrangement for (o/p)-hydroxy-o-methylphenacyl esters that ... -
Synthesis of Cruentaren A
(American Chemical Society, 2012-12-21)Cruentaren A, an antifungal benzolactone produced by the myxobacterium Byssovorax cruenta, is highly cytotoxic against various human cancer cell lines and a highly selective inhibitor of mitochondrial F-ATPase. A convergent ... -
ROMP-derived Oligomeric Phosphates for Application in Facile Benzylation
(American Chemical Society, 2010-07-12)The development of new ROMP-based oligomeric benzyl phosphates (OBPn) is reported for use as soluble, stable benzylating reagents. These oligomeric reagents are readily synthesized from commercially available materials and ... -
Regiospecific decarboxylative allylation of nitriles
(American Chemical Society, 2009-12-17)Palladium-catalyzed decarboxylative α-allylation of nitriles readily occurs using Pd2(dba)3 and rac-BINAP. This catalyst mixture also allows the highly regiospecific α-allylation of nitriles in the presence of much more ...