Monomer-on-Monomer (MoM) Mitsunobu Reaction: Facile Purification Utilizing Surface-Initiated Sequestration

Maity, Pradip K.; Rolfe, Alan; Samarakoon, Thiwanka Bandara; Faisal, Saqib; Kurtz, Ryan D.; Long, Toby R.; Schätz, Alexander; Flynn, Daniel L.; Grass, Robert N.; Stark, Wendelin J.; Reiser, Oliver; Hanson, Paul R.

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Issue Date

2011-01-07

Author

Maity, Pradip K.

Rolfe, Alan

Samarakoon, Thiwanka Bandara

Faisal, Saqib

Kurtz, Ryan D.

Long, Toby R.

Schätz, Alexander

Flynn, Daniel L.

Grass, Robert N.

Stark, Wendelin J.

Reiser, Oliver

Hanson, Paul R.

Publisher

American Chemical Society

Type

Article

Article Version

Scholarly/refereed, author accepted manuscript

Rights

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/ol1022382.

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Abstract

A monomer-on-monomer (MoM) Mitsunobu reaction utilizing norbornenyl-tagged (Nb-tagged) reagents is reported, whereby purification was rapidly achieved by employing ring-opening metathesis polymerization which is initiated by any of three methods utilizing Grubbs catalyst (i) free catalyst in solution, (ii) surface-initiated catalyst-armed silica or (iii) surface-initiated catalyst-armed Co/C magnetic nanoparticles.

Citation

Maity, P. K., Rolfe, A., Samarakoon, T. B., Faisal, S., Kurtz, R. D., Long, T. R., … Hanson, P. R. (2011). Monomer-on-Monomer (MoM) Mitsunobu Reaction: Facile Purification Utilizing Surface-Initiated Sequestration. Organic Letters, 13(1), 8–10. http://doi.org/10.1021/ol1022382

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