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Molecular Biosciences: Recent submissions
Now showing items 641-660 of 887
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CHARACTERIZATION OF THE STRUCTURE, FUNCTION, AND PROTEIN-PROTEIN INTERACTIONS INVOLVED IN THE ASSEMBLY OF THE TYPE III SECRETION SYSTEM TIP COMPLEX AND THE TRANSLOCON OF SALMONELLA AND SHIGELLA
(University of Kansas, 2013-08-31)The type III secretion system (T3SS) is a macromolecular structure assembled by many Gram-negative bacteria in order to invade target host cells. A functional T3SS contains a syringe-like structural component known as the ... -
Driving Functional Behavioral Recovery Using Activity-Dependent Stimulation
(University of Kansas, 2012-12-31)The purpose of this project was to determine if artificially linking spared motor and sensory areas following a cortical lesion would lead to increased behavioral recovery on a skilled reaching task. Sensory-motor integration ... -
Hormonal regulation of microRNA expression in the ovary
(University of Kansas, 2012-12-31)The ovary is a dynamic organ that is charged with the responsibility of producing a viable gamete so that the circle of life can be reproduced for future generations. The ovary is also responsible for producing, secreting, ... -
MOLECULAR MECHANISMS OF THE DNA DAMAGE RESPONSE INDUCED DURING PARVOVIRUS INFECTION
(University of Kansas, 2012-12-31)DNA damage response (DDR) is a critical safeguarding system to protect genomic stability and integrality through a cascade of phosphorylation events of three PI-3-kinase-like kinases: ATM (ataxia telangiectasia mutated), ... -
OUTPUT FROM MOTOR CORTEX TO CONTRALATERAL AND IPSILATERAL HINDLIMB MUSCLES IN THE PRIMATE
(University of Kansas, 2012-12-31)Although corticospinal control of the forelimb has been heavily studied for several decades, relatively little is known about corticospinal control of the hindlimb despite its importance. The overall goal of this project ... -
THE ROLE OF DMRT1 IN POSTNATAL TESTIS DIFFERENTIATION
(University of Kansas, 2012-01-01)DMRT1 (doublesex and maleabnormal-3 related transcription factor-1) is a transcription regulator that is expressed in Sertoli cells and germ cells of the testis, where it directs mammalian postnatal testis differentiation. ... -
Structure-Based Design of Non-Natural Amino Acid Inhibitors of Amyloid Fibrillation
(Nature Publishing Group, 2011-06-07)Many globular and natively disordered proteins can convert into amyloid fibers. These fibers are associated with numerous pathologies1 as well as with normal cellular functions2,3, and frequently form during protein ... -
Drug Resistance and Molecular Cancer Therapy: Apoptosis Versus Autophagy
(InTech, 2013-04-15) -
The Structure of the Herpes Simplex Virus DNA-Packaging Terminase pUL15 Nuclease Domain Suggests an Evolutionary Lineage among Eukaryotic and Prokaryotic Viruses
(American Society of Microbiology, 2013-04-17)Herpes simplex virus 1 (HSV-1), the prototypic member of herpesviruses, employs a virally encoded molecular machine called terminase to package the viral double-stranded DNA (dsDNA) genome into a preformed protein shell. ... -
Structure of the NS1 Protein N-Terminal Origin Recognition/Nickase Domain from the Emerging Human Bocavirus
(American Society of Microbiology, 2013-08-21)Human bocavirus is a newly identified, globally prevalent, parvovirus that is associated with respiratory infection in infants and young children. Parvoviruses encode a large nonstructural protein 1 (NS1) that is essential ... -
The Development and Validation of a High-throughput Screening Method for Chlamydia trachomatis
(University of Kansas, 2014-05-31)High-throughput screening is a scientific method that can be used to identify small compounds with activity against a number of bacteria and other organisms, as well as diseases, such as cancer, in a cost efficient manner ... -
Calcium signaling components and their effect on synaptic morphology during neuronal development
(University of Kansas, 2014-05-31)Along with regulating synaptic transmission, voltage-gated calcium channel (VGCC) function is responsible for a myriad of cellular outputs, ranging from gene expression to shaping synaptic morphology. Despite the morphological ... -
Interplay Between Viral and Cellular Factors Determines the Fate of Herpes Simplex Virus type I Infection
(University of Kansas, 2014-05-31)The herpes simplex virus type I (HSV-1) is a major human pathogen that infects the majority of the world's population. The life cycle of HSV-1 is controlled by interactions with its hosts. Understanding virus-host interactions ... -
Spatial regulation of cell division by the nucleoid occlusion protein SlmA in Escherichia coli
(University of Kansas, 2014-05-31)Spatial regulation of cell division in bacteria occurs at the stage of Z ring formation, a cytoskeletal element that bacterial cells employ for assembly of the cell division machinery. In the model organism Escherichia ... -
Functional transcriptomic analysis of the role of MAB-5/Hox in Q neuroblast migration in Caenorhabditis elegans
(BioMed Central, 2013-05-04)Background: Directed cell migration is a fundamental process in normal development and in tumor metastasis. In C. elegans the MAB-5/Hox transcription factor is a determinant of posterior migration of the Q neuroblast ... -
Eep confers lysozyme resistance to enterococcus faecalis via the activation of the extracytoplasmic function sigma factor SigV
(American Society of Microbiology, 2013-05-03)Enterococcus faecalis is a commensal bacterium found in the gastrointestinal tract of most mammals, including humans, and is one of the leading causes of nosocomial infections. One of the hallmarks of E. faecalis pathogenesis ... -
Small-Molecule Inhibitor of the Shigella flexneri Master Virulence Regulator VirF
(American Society for Microbiology, 2013-09-03)VirF is an AraC family transcriptional activator that is required for the expression of virulence genes associated with invasion and cell-to-cell spread by Shigella flexneri, including multiple components of the type three ... -
N-Terminal Phosphorylation Sites of Herpes Simplex Virus 1 ICP0 Differentially Regulate Its Activities and Enhance Viral Replication
(American Society for Microbiology, 2013-02)The herpes simplex virus 1 (HSV-1) infected cell protein 0 (ICP0) is an immediate-early phosphoprotein that transactivates viral gene expression. Evidence suggests that phosphorylation regulates the functions of ICP0, and ... -
A Method of Differentiating Fibers in Textile Fabrics
(The University of Kansas, 1910) -
Studies of the Micro-Bacillus of Acne and Clinical Studies of Cases Treated by Vaccines
(The University of Kansas, 1911)