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    The NC1/Endostatin Domain of Caenorhabditis elegans Type XVIII Collagen Affects Cell Migration and Axon Guidance

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    Ackley_2001_NC1Endostatin.pdf (995.9Kb)
    Issue Date
    2001-03-19
    Author
    Ackley, Brian D.
    Crew, Jennifer R.
    Elamaa, Harri
    Pihlajaniemi, Tania
    Kuo, Calvin J.
    Kramer, James M.
    Publisher
    The Rockefeller University Press
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
    Metadata
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    Abstract
    Type XVIII collagen is a homotrimeric basement membrane molecule of unknown function, whose COOH-terminal NC1 domain contains endostatin (ES), a potent antiangiogenic agent. The Caenorhabditis elegans collagen XVIII homologue, cle-1, encodes three developmentally regulated protein isoforms expressed predominantly in neurons. The CLE-1 protein is found in low amounts in all basement membranes but accumulates at high levels in the nervous system. Deletion of the cle-1 NC1 domain results in viable fertile animals that display multiple cell migration and axon guidance defects. Particular defects can be rescued by ectopic expression of the NC1 domain, which is shown to be capable of forming trimers. In contrast, expression of monomeric ES does not rescue but dominantly causes cell and axon migration defects that phenocopy the NC1 deletion, suggesting that ES inhibits the promigratory activity of the NC1 domain. These results indicate that the cle-1 NC1/ES domain regulates cell and axon migrations in C. elegans.
    Description
    This is the publisher's version, also available electronically from http://jcb.rupress.org/content/152/6/1219.
    URI
    http://hdl.handle.net/1808/15182
    DOI
    https://doi.org/10.1083/jcb.152.6.1219
    ISSN
    0021-9525
    Collections
    • Molecular Biosciences Scholarly Works [458]
    Citation
    Ackley, B.D.; Crew, J.R.; Elamaa, H.; Pihlajaniemi, T.; Kuo, C.J.; Kramer, J.M. (2001). "The NC1/Endostatin Domain of Caenorhabditis elegans Type XVIII Collagen Affects Cell Migration and Axon Guidance." Journal of Cellular Biology, 152(6):1219. http://www.dx.doi.org/10.1083/jcb.152.6.1219.

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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