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Pharmaceutical Chemistry Scholarly Works: Recent submissions
Now showing items 221-240 of 358
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Improving the Stability of the EC1 Domain of E-cadherin by Thiol Alkylation of the Cysteine Residue
(Elsevier, 2013-07-15)The objective of this work was to improve chemical and physical stability of the EC1 protein derived from the extracellular domain of E-cadherin. In solution, the EC1 protein has been shown to form a covalent dimer via a ... -
Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent
(Elsevier, 2011-05-31)Aerosolized contrast agents may improve the resolution of biomedical imaging modalities and enable more accurate diagnosis of lung diseases. Many iodinated compounds, such as diatrizoic acid, have been shown to be safe and ... -
Protein thiyl radical reactions and product formation: a kinetic simulation
(Elsevier, 2016-11-22)Protein thiyl radicals are important intermediates generated in redox processes of thiols and disulfides. Thiyl radicals efficiently react with glutathione and ascorbate, and the common notion is that these reactions serve ... -
Myeloperoxidase-derived oxidants inhibit sarco/endoplasmic reticulum Ca2+-ATPase activity, and perturb Ca2+ homeostasis in human coronary artery endothelial cells
(Elsevier, 2013-08-07)The sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) plays a critical role in Ca2+ homeostasis via sequestration of this ion into the sarco/endoplasmic reticulum. The activity of this pump is inhibited by oxidants and ... -
Introduction: What we do and do not know regarding redox processes of thiols in signaling pathways
(Elsevier, 2016-03-01)Due to their susceptibility towards redox modification, protein thiols represent primary targets for the modulation of protein activity, conformation and oligomerization. Until fairly recently, such modifications were ... -
Lymphatic trafficking kinetics and near-infrared imaging using star polymer architectures with controlled anionic character
(Elsevier, 2015-01-21)Targeted lymphatic delivery of nanoparticles for drug delivery and imaging is primarily dependent on size and charge. Prior studies have observed increased lymphatic uptake and retentions of over 48 hrs for negatively ... -
ICAM-1 Targeting of Doxorubicin-Loaded PLGA Nanoparticles to Lung Epithelial Cells
(Elsevier, 2010-05-12)Interaction of leukocyte function associated antigen-1 (LFA-1) on T-lymphoctytes and intercellular adhesion molecule-1 (ICAM-1) on epithelial cells controls leukocyte adhesion, spreading, and extravasation. This process ... -
Opioid Peptides: Potential for Drug Development
(Elsevier, 2013-04-01)Opioid receptors are important targets for the treatment of pain and potentially for other disease states (e.g. mood disorders and drug abuse) as well. Significant recent advances have been made in identifying opioid peptide ... -
The role of thiols and disulfides in protein chemical and physical stability
(Bentham Science Publishers, 2012-04-04) -
LFA-1 on Leukemic Cells as a Target for Therapy or Drug Delivery
(Bentham Science Publishers, 2014-10-23)Leukemia therapeutics are aiming for improved efficacy by targeting molecular markers differentially expressed on cancerous cells. Lymphocyte function-associated antigen-1 (LFA-1) expression on various types of leukemia ... -
Microsphere-based scaffolds encapsulating chondroitin sulfate or decellularized cartilage
(SAGE Publications, 2016-09)Extracellular matrix materials such as decellularized cartilage (DCC) and chondroitin sulfate (CS) may be attractive chondrogenic materials for cartilage regeneration. The goal of the current study was to investigate the ... -
Biodegradable PLGA Based Nanoparticles for Sustained Regional Lymphatic Drug Delivery
(Elsevier, 2010-04)The purpose of this work is to evaluate biodegradable drug carriers with defined size, hydrophobicity, and surface charge density for preferential lymphatic uptake and retention for sustained regional drug delivery. ... -
Subcutaneous Delivery of Nanoconjugated Doxorubicin and Cisplatin for Locally Advanced Breast Cancer Demonstrates Improved Efficacy and Decreased Toxicity at Lower Doses Than Standard Systemic Combination Therapy In Vivo
(Elsevier, 2011-10-08)Background—Combination cytotoxic agents in breast cancer carry dose-limiting toxicities. We hypothesize that nanocarrier-conjugated doxorubicin and cisplatin will have improved tumor efficacy with decreased systemic ... -
Toxicity of nanomaterials
(Royal Society of Chemistry, 2016-01-06)Nanoscience has matured significantly during the last decade as it has transitioned from bench top science to applied technology. Presently, nanomaterials are used in a wide variety of commercial products such as electronic ... -
Suppression of EAE and Prevention of Blood-Brain Barrier Breakdown after Vaccination with Novel Bifunctional Peptide Inhibitor
(Elsevier, 2012-03)The efficacy of bifunctional peptide inhibitor (BPI) in preventing blood-brain barrier (BBB) breakdown during onset of experimental autoimmune encephalomyelitis (EAE) and suppression of the disease was evaluated in mice. ... -
A Novel Intralymphatic Nanocarrier-Delivery System for Cisplatin Therapy in Breast Cancer with Improved Tumor Efficacy and Lower Systemic Toxicity In Vivo
(Elsevier Masson, 2010-12-01)Background A lymphatically delivered nanoconjugate of cisplatin was evaluated in an orthotopic mouse model of locoregionally metastatic breast cancer (LABC) to determine if it can overcome some of the limitations of ... -
Lymphatic drug delivery: therapy, imaging and nanotechnology
(Elsevier, 2016-04-11) -
Effects of nanomaterial physicochemical properties on in vivo toxicity
(Elsevier, 2010-06-21)It is well recognized that physical and chemical properties of materials can alter dramatically at nanoscopic scale, and the growing use of nanotechnologies requires careful assessment of unexpected toxicities and biological ... -
Advances in Lymphatic Imaging and Drug Delivery
(Elsevier, 2012-09-10)Cancer remains the second leading cause of death after heart disease in the US. While metastasized cancers such as breast, prostate, and colon are incurable, before their distant spread, these diseases will have invaded ... -
In vivo photoacoustic imaging of breast cancer tumor with HER2-targeted nanodiamonds
(Society of Photo-optical Instrumentation Engineers, 2013-09-20)Radiation-damaged nanodiamonds (NDs) are ideal optical contrast agents for photoacoustic (PA) imaging in biological tissues due to their good biocompatibility and high optical absorbance in the near-infrared (NIR) range. ...