• 

  Wearable Sensing System for NonInvasive Monitoring of Intracranial BioFluid Shifts in Aerospace Applications 

  Griffith, Jacob L.; Cluff, Kim; Downes, Grant M.; Eckerman, Brandon; Bhandari, Subash; Loflin, Benjamin E.; Becker, Ryan; Alruwaili, Fayez; Mohammed, Noor (MDPI, 2023-01-14)

  The alteration of the hydrostatic pressure gradient in the human body has been associated with changes in human physiology, including abnormal blood flow, syncope, and visual impairment. The focus of this study was to ...
• 

  Rational inhibitor design for Pseudomonas aeruginosa salicylate adenylation enzyme PchD 

  Shelton, Catherine L.; Meneely, Kathleen M.; Ronnebaum, Trey A.; Chilton, Annemarie S.; Riley, Andrew P.; Prisinzano, Thomas E.; Lamb, Audrey L. (Springer, 2022-05-05)

  Pseudomonas aeruginosa is an increasingly antibiotic-resistant pathogen that causes severe lung infections, burn wound infections, and diabetic foot infections. P. aeruginosa produces the siderophore pyochelin through the ...
• 

  Mapping monoclonal anti-SARS-CoV-2 antibody repertoires against diverse coronavirus antigens 

  de Souza, Matheus Oliveira; Madan, Bharat; Teng, I-Ting; Huang, Aric; Liu, Lihong; Fahad, Ahmed S.; Lopez Acevedo, Sheila N.; Pan, Xiaoli; Sastry, Mallika; Gutierrez-Gonzalez, Matias; Yin, Michael T.; Zhou, Tongqing; Ho, David D.; Kwong, Peter D.; DeKosky, Brandon J. (Frontiers Media, 2022-09-02)

  Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged continuously, challenging the effectiveness of vaccines, diagnostics, and treatments. Moreover, the possibility of the appearance of a ...
• 

  Novel Approaches for Overcoming Biological Barriers 

  Agrahari, Vibhuti; Kumar, Prashant (MDPI, 2022-09-02)
• 

  Structural Design and Synthesis of Novel Cyclic Peptide Inhibitors Targeting Mycobacterium tuberculosis Transcription 

  Stephanie, Filia; Saragih, Mutiara; Tambunan, Usman Sumo Friend; Siahaan, Teruna J. (MDPI, 2022-08-28)

  Tuberculosis (TB) remains one of the deadliest infectious diseases in the world. Although several established antitubercular drugs have been found, various factors obstruct efforts to combat this disease due to the existence ...
• 

  Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates 

  Padilla, Angel M.; Wang, Wei; Akama, Tsutomu; Carter, David S.; Easom, Eric; Freund, Yvonne; Halladay, Jason S.; Liu, Yang; Hamer, Sarah A.; Hodo, Carolyn L.; Wilkerson, Gregory K.; Orr, Dylan; White, Brooke; George, Arlene; Shen, Huifeng; Jin, Yiru; Zhuo Wang, Michael; Tse, Susanna; Jacobs, Robert T.; Tarleton, Rick L. (Nature Research, 2022-09-05)

  Trypanosoma cruzi, the agent of Chagas disease, probably infects tens of millions of people, primarily in Latin America, causing morbidity and mortality. The options for treatment and prevention of Chagas disease are limited ...
• 

  Doxorubicin-Loaded Polymeric Micelles Conjugated with CKR- and EVQ-FLT3 Peptides for Cytotoxicity in Leukemic Stem Cells 

  Chueahongthong, Fah; Tima, Singkome; Chiampanichayakul, Sawitree; Dejkriengkraikul, Pornngarm; Okonogi, Siriporn; Sasarom, Mathurada; Rodwattanagul, Soraya; Berkland, Cory; Anuchapreeda, Songyot (MDPI, 2022-10-04)

  Doxorubicin (Dox) is the standard chemotherapeutic agent for acute myeloblastic leukemia (AML) treatment. However, 40% of Dox-treated AML cases relapsed due to the presence of leukemic stem cells (LSCs). Thus, poloxamer ...
• 

  Immune Modulation by Antigenic Peptides and Antigenic Peptide Conjugates for Treatment of Multiple Sclerosis 

  Mahadik, Rucha; Kiptoo, Paul; Tolbert, Tom; Siahaan, Teruna J. (Elsevier, 2022-06-01)

  The immune system defends our body by fighting infection from pathogens utilizing both the innate and adaptive immune responses. The innate immune response is generated rapidly as the first line of defense. It is followed ...
• 

  Spermidine/Spermine N1-Acetyltransferase 1 (SAT1)—A Potential Gene Target for Selective Sensitization of Glioblastoma Cells Using an Ionizable Lipid Nanoparticle to Deliver siRNA 

  Yathindranath, Vinith; Safa, Nura; Sajesh, Babu V.; Schwinghamer, Kelly; Vanan, Magimairajan Issai; Bux, Rashid; Sitar, Daniel S.; Pitz, Marshall; Siahaan, Teruna J.; Miller, Donald W. (MDPI, 2022-10-22)

  Spermidine/spermine N1-acetyltransferase 1 (SAT1) responsible for cell polyamine catabolism is overexpressed in glioblastoma multiforme (GB). Its role in tumor survival and promoting resistance towards radiation therapy ...
• Measurement of Adenovirus-Based Vector Heterogeneity (Dataset) 

  Hickey, John M.; Jacob, Shaleem I.; Tait, Andrew S.; Dastjerdi, Fatemeh V.; Barritt, Joseph; Rouse, Sarah; Douglas, Alexander; Joshi, Sangeeta B.; Volkin, David B.; Bracewell, Daniel G. (Elsevier, 2022)

  Adenovirus vectors have become an important class of vaccines with the recent approval of Ebola and COVID-19 products. In-process quality attribute data collected during Adenovirus vector manufacturing has focused on ...
• Multi-dose Formulation Development for a Quadrivalent Human Papillomavirus Virus-Like Particle-Based Vaccine: Part II- Real-time and Accelerated Stability Studies (Dataset) 

  Sharma, Nitya; Jerajani, Kaushal; Wan, Ying; Kumru, Ozan S.; Pullagurla, Swathi R.; Ogun, Oluwadara; Mapari, Shweta; Brendle, Sarah; Christensen, Neil D.; Batwal, Saurabh; Mahedvi, Mustafa; Rao, Harish; Dogar, Vikas; Chandrasekharan, Rahul; Shaligram, Umesh; Volkin, David B.; Joshi, Sangeeta B. (Elsevier, 2022-11-21)

  This work describes Part 2 of multi-dose formulation development of a Human Papillomavirus (HPV) Virus-Like Particles (VLPs) containing vaccine (see Part 1 in companion paper). Storage stability studies with candidate ...
• 

  Ultrasound-assisted laser thrombolysis with endovascular laser and high-intensity focused ultrasound 

  Jo, Janggun; Forrest, M. Laird; Yang, Xinmai (Wiley, 2020-12-05)

  Purpose The combination of laser and ultrasound can significantly improve the efficiency of thrombolysis through an enhanced cavitation effect. We developed a fiber optics-based laser-ultrasound thrombolysis device and ...
• 

  Sterol profiling of Leishmania parasites using a new HPLC-tandem mass spectrometry-based method and antifungal azoles as chemical probes reveals a key intermediate sterol that supports a branched ergosterol biosynthetic pathway 

  Feng, Mei; Jin, Yiru; Yang, Sihyung; Joachim, Arline M.; Ning, Yu; Mori-Quiroz, Luis M.; Fromm, Jacob; Perera, Chamani; Zhang, Kai; Werbovetz, Karl A.; Wang, Michael Zhuo (Elsevier, 2022-08-15)

  Human leishmaniasis is an infectious disease caused by Leishmania protozoan parasites. Current chemotherapeutic options against the deadly disease have significant limitations. The ergosterol biosynthetic pathway has been ...
• 

  A Novel Drug Modulator Diarylheptanoid (trans-1,7-Diphenyl-5-hydroxy-1-heptene) from Curcuma comosa Rhizomes for P-glycoprotein Function and Apoptosis Induction in K652/ADR Leukemic Cells 

  Viriyaadhammaa, Natsima; Duangmano, Suwit; Saiai, Aroonchai; Tungjai, Montree; Dejkriengkraikul, Pornngarm; Tima, Singkome; Chiampanichayakul, Sawitree; Krise, Jeffrey; Anuchapreeda, Songyot (MDPI, 2022-08-12)

  Curcuma comosa has been used in traditional Thai medicine to treat menstrual cycle-related symptoms in women. This study aims to evaluate the diarylheptanoid drug modulator, trans-1,7-diphenyl-5-hydroxy-1-heptene (DHH), ...
• 

  Concordance of in vitro and in vivo measures of non-replicating rotavirus vaccine potency 

  McAdams, David; Estrada, Marcus; Holland, David; Singh, Jasneet; Sawant, Nishant; Hickey, John M.; Kumar, Prashant; Plikaytis, Brian; Joshi, Sangeeta B.; Volkin, David B.; Sitrin, Robert; Cryz, Stan; White, Jessica A. (Elsevier, 2022-07-22)

  Rotavirus infections remain a leading cause of morbidity and mortality among infants residing in low- and middle-income countries. To address the large need for protection from this vaccine-preventable disease we are ...
• 

  Development of a Broadly Protective, Self-Adjuvanting Subunit Vaccine to Prevent Infections by Pseudomonas aeruginosa 

  Das, Sayan; Howlader, Debaki R.; Zheng, Qi; Ratnakaram, Siva Sai Kumar; Whittier, Sean K.; Lu, Ti; Keith, Johnathan D.; Picking, William D.; Birket, Susan E.; Picking, Wendy L. (Frontiers Media, 2020-11-17)

  Infections caused by the opportunistic pathogen Pseudomonas aeruginosa can be difficult to treat due to innate and acquired antibiotic resistance and this is exacerbated by the emergence of multi-drug resistant strains. ...
• Multi-dose Formulation Development for a Quadrivalent Human Papillomavirus Virus-Like Particle-Based Vaccine: Part I- Screening of Preservative Combinations (Dataset) 

  Jerajani, Kaushal; Wan, Ying; Kumru, Ozan S.; Pullagurla, Swathi R.; Kumar, Prashant; Sharma, Nitya; Ogun, Oluwadara; Mapari, Shweta; Brendle, Sarah; Christensen, Neil D.; Batwal, Saurabh; Mahedvi, Mustafa; Rao, Harish; Dogar, Vikas; Chandrasekharan, Rahul; Shaligram, Umesh; Joshi, Sangeeta B.; Volkin, David B. (Elsevier, 2022-08)

  The development of multi-dose, subunit vaccine formulations can be challenging since antimicrobial preservatives (APs) often destabilize protein antigens. In this work, we evaluated Human Papillomavirus (HPV) Virus-Like ...
• 

  Development of spirulina for the manufacture and oral delivery of protein therapeutics 

  Jester, Benjamin W.; Zhao, Hui; Gewe, Mesfin; Adame, Thomas; Perruzza, Lisa; Bolick, David T.; Agosti, Jan; Khuong, Nhi; Kuestner, Rolf; Gamble, Caitlin; Cruickshank, Kendra; Ferrara, Jeremy; Lim, Rachelle; Paddock, Troy; Brady, Colin; Ertel, Stacey; Zhang, Miaohua; Pollock, Alex; Lee, Jamie; Xiong, Jian; Tasch, Michael; Saveria, Tracy; Doughty, David; Marshall, Jacob; Carrieri, Damian; Goetsch, Lauren; Dang, Jason; Sanjaya, Nathaniel; Fletcher, David; Martinez, Anissa; Kadis, Bryce; Sigmar, Kristjan; Afreen, Esha; Nguyen, Tammy; Randolph, Amanda; Taber, Alexandria; Krzeszowski, Ashley; Robinett, Brittney; Volkin, David B.; Grassi, Fabio; Guerrant, Richard; Takeuchi, Ryo; Finrow, Brian; Behnke, Craig; Roberts, James (Nature Research, 2022-03-21)

  The use of the edible photosynthetic cyanobacterium Arthrospira platensis (spirulina) as a biomanufacturing platform has been limited by a lack of genetic tools. Here we report genetic engineering methods for stable, ...
• 

  Strategies to Screen Anti-AQP4 Antibodies from Yeast Surface Display Libraries 

  Huang, Aric; Jin, Wei; Fahad, Ahmed S.; Mussman, Brooklyn K.; Nicchia, Grazia Paola; Madan, Bharat; de Souza, Matheus Oliveira; Griffin, J. Daniel; Bennett, Jeffrey L.; Frigeri, Antonio; Berkland, Cory J.; DeKosky, Brandon J. (MDPI, 2022-06-05)

  A rapid and effective method to identify disease-specific antibodies from clinical patients is important for understanding autoimmune diseases and for the development of effective disease therapies. In neuromyelitis optica ...
• Analytical and Preformulation Characterization Studies of Human Papillomavirus Virus-Like Particles to Enable Quadrivalent Multi-Dose Vaccine Formulation Development (Dataset) 

  Jerajani, Kaushal; Wan, Ying; Hickey, John M.; Kumru, Ozan S.; Sharma, Nitya; Pullagurla, Swathi R.; Ogun, Oluwadara; Mapari, Shweta; Whitaker, Neal; Brendle, Sarah; Christensen, Neil D.; Batwal, Saurabh; Mahedvi, Mustafa; Rao, Harish; Dogar, Vikas; Chandrasekharan, Rahul; Shaligram, Umesh; Joshi, Sangeeta B.; Volkin, David B. (Elsevier, 2022)

  Introducing multi-dose formulations of Human Papillomavirus (HPV) vaccines will reduce costs and enable improved global vaccine coverage, especially in low- and middle-income countries. This work describes the development ...

View more