Pharmaceutical Chemistry
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Formulation development and comparability studies with an aluminum-salt adjuvanted SARS-CoV-2 Spike ferritin nanoparticle vaccine antigen produced from two different cell lines (Dataset)
(Elsevier, 2023)The development of safe and effective second-generation COVID-19 vaccines to improve affordability and storage stability requirements remains a high priority to expand global coverage. In this report, we describe formulation ... -
Physicochemical characterization of biological and synthetic forms of two lipid A-based TLR4 agonists
(Elsevier, 2023-07-08)Toll-like receptor (TLR) agonists are recognized as potential immune-enhancing adjuvants and are included in several licensed vaccines. Monophosphoryl lipid A (MPL®, GlaxoSmithKline) is one such TLR4 agonist that has been ... -
Immunogenicity and protective efficacy of nanoparticle formulations of L-SseB against Salmonella infection
(Frontiers Media, 2023-06-30)Salmonella enterica, a Gram-negative pathogen, has over 2500 serovars that infect a wide range of hosts. In humans, S. enterica causes typhoid or gastroenteritis and is a major public health concern. In this study, SseB ... -
Primary Processes of Free Radical Formation in Pharmaceutical Formulations of Therapeutic Proteins
(MDPI, 2023-07-17)Oxidation represents a major pathway for the chemical degradation of pharmaceutical formulations. Few specific details are available on the mechanisms that trigger oxidation reactions in these formulations, specifically ... -
Large-scale antibody immune response mapping of splenic B cells and bone marrow plasma cells in a transgenic mouse model
(Frontiers Media, 2023-06-05)Molecular characterization of antibody immunity and human antibody discovery is mainly carried out using peripheral memory B cells, and occasionally plasmablasts, that express B cell receptors (BCRs) on their cell surface. ... -
Development of an In Vitro System To Emulate an In Vivo Subcutaneous Environment: Small Molecule Drug Assessment
(American Chemical Society, 2022-10-24)A reliable in vitro system can support and guide the development of subcutaneous (SC) drug products. Although several in vitro systems have been developed, they have some limitations, which may hinder them from getting ... -
Development of Drug Release Model for Suspensions in ESCAR (Emulator of SubCutaneous Absorption and Release)
(Springer, 2023-03-22)We recently developed an in vitro testing system, namely, ESCAR (Emulator of SubCutaneous Absorption and Release). The objective of this work was to investigate drug release behaviors of unmilled and milled suspensions in ... -
The HRA2pl fusion peptide exerts in vitro antiviral activity against human respiratory paramyxoviruses and pneumoviruses
(Frontiers Media, 2023-04-20)Acute respiratory infections are a group of diseases caused by viruses, bacteria, and parasites that mainly affect children until the age of 5 and immunocompromised senior adults. In Mexico, these infections are the main ... -
Cell activation-based screening of natively paired human T cell receptor repertoires
(Nature Research, 2023-05-17)Adoptive immune therapies based on the transfer of antigen-specific T cells have been used successfully to treat various cancers and viral infections, but improved techniques are needed to identify optimally protective ... -
Correlating physicochemical and biological properties to define critical quality attributes of a recombinant AAV vaccine candidate (Dataset)
(Cell Press, 2023)Recombinant adeno-associated viruses (rAAVs) are a preferred vector system in clinical gene transfer. A fundamental challenge to formulate and deliver rAAVs as stable and efficacious vaccines is to elucidate interrelationships ... -
Noninvasive Brain Delivery and Efficacy of BDNF to Stimulate Neuroregeneration and Suppression of Disease Relapse in EAE Mice
(American Chemical Society, 2019-12-17)The number of FDA-approved protein drugs (biologics), such as antibodies, antibody–drug conjugates, hormones, and enzymes, continues to grow at a rapid rate; most of these drugs are used to treat diseases of the peripheral ... -
Challenges in the Development of Intravenous Neurokinin-1 Receptor Antagonists: Results of a Safety and Pharmacokinetics Dose-Finding, Phase 1 Study of Intravenous Fosnetupitant
(Wiley, 2022-10-20)Oral NEPA is the fixed-combination antiemetic comprising netupitant (neurokinin-1 receptor antagonist [NK1RA]) and palonosetron (5-hydroxytryptamine-3 receptor antagonist [5-HT3 RA]). Intravenous (IV) NEPA, containing ... -
A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates
(Nature Research, 2023-04-17)While the rapid development of COVID-19 vaccines has been a scientific triumph, the need remains for a globally available vaccine that provides longer-lasting immunity against present and future SARS-CoV-2 variants of ... -
Nanoalum formulations containing aluminum hydroxide and CpG 1018 adjuvants: The effect on stability and immunogenicity of a recombinant SARS-CoV-2 RBD antigen
(MDPI, 2023)Aluminum-salt vaccine adjuvants (alum) are commercially available as micron-sized particles with varying chemical composition and crystallinity. There are reports of enhanced adjuvanticity when the alum’s particle size is ... -
Current and next-generation formulation strategies for inactivated polio vaccines to lower costs, increase coverage, and facilitate polio eradication
(Taylor and Francis Group, 2022-12-28)Implementation of inactivated polio vaccines (IPV) containing Sabin strains (sIPV) will further enable global polio eradication efforts by improving vaccine safety during use and containment during manufacturing. Moreover, ... -
A protein subunit vaccine elicits a balanced immune response that protects against Pseudomonas pulmonary infection
(Nature Research, 2023-03-14)The opportunistic pathogen Pseudomonas aeruginosa (Pa) causes severe nosocomial infections, especially in immunocompromised individuals and the elderly. Increasing drug resistance, the absence of a licensed vaccine and ... -
Designing Formulation Strategies for Enhanced Stability of Therapeutic Peptides in Aqueous Solutions: A Review
(MDPI, 2023-03-14)Over the past few decades, there has been a tremendous increase in the utilization of therapeutic peptides. Therapeutic peptides are usually administered via the parenteral route, requiring an aqueous formulation. ... -
Wearable Sensing System for NonInvasive Monitoring of Intracranial BioFluid Shifts in Aerospace Applications
(MDPI, 2023-01-14)The alteration of the hydrostatic pressure gradient in the human body has been associated with changes in human physiology, including abnormal blood flow, syncope, and visual impairment. The focus of this study was to ... -
Rational inhibitor design for Pseudomonas aeruginosa salicylate adenylation enzyme PchD
(Springer, 2022-05-05)Pseudomonas aeruginosa is an increasingly antibiotic-resistant pathogen that causes severe lung infections, burn wound infections, and diabetic foot infections. P. aeruginosa produces the siderophore pyochelin through the ... -
Mapping monoclonal anti-SARS-CoV-2 antibody repertoires against diverse coronavirus antigens
(Frontiers Media, 2022-09-02)Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged continuously, challenging the effectiveness of vaccines, diagnostics, and treatments. Moreover, the possibility of the appearance of a ...