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    LFA-1 on Leukemic Cells as a Target for Therapy or Drug Delivery

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    berkland_leukemic.pdf (1.330Mb)
    Issue Date
    2014-10-23
    Author
    Phongpradist, Rungsinee
    Chittasupho, Chuda
    Okonogi, Siriporn
    Siahaan, Teruna J.
    Anuchapreeda, Songyot
    Ampasavate, Chadarat
    Berkland, Cory J.
    Publisher
    Bentham Science Publishers
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
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    Abstract
    Leukemia therapeutics are aiming for improved efficacy by targeting molecular markers differentially expressed on cancerous cells. Lymphocyte function-associated antigen-1 (LFA-1) expression on various types of leukemia has been well studied. Here, the role and expression of LFA-1 on leukemic cells and the possibility of using this integrin as a target for drug delivery is reviewed. To support this rationale, experimental results were also included where cIBR, a cyclic peptide derived from a binding site of LFA-1, was conjugated to the surface of polymeric nanoparticles and used as a targeting ligand. These studies revealed a correlation of LFA-1 expression level on leukemic cell lines and binding and internalization of cIBR-NPs suggesting a differential binding and internalization of cIBR-NPs to leukemic cells overexpressing LFA-1. Nanoparticles conjugated with a cyclic peptide against an accessible molecular marker of disease hold promise as a selective drug delivery system for leukemia treatment.
    URI
    http://hdl.handle.net/1808/23320
    DOI
    https://doi.org/10.2174/138161210791920450 
    Collections
    • Pharmaceutical Chemistry Scholarly Works [252]
    Citation
    Phongpradist, Rungsinee, Chuda Chittasupho, Siriporn Okonogi, Teruna Siahaan, Songyot Anuchapreeda, Chadarat Ampasavate, and Cory Berkland. "LFA-1 on Leukemic Cells as a Target for Therapy or Drug Delivery." Current Pharmaceutical Design 16.21 (2010): 2321-330.

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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