In vivo photoacoustic imaging of breast cancer tumor with HER2-targeted nanodiamonds
Forrest, M. Laird
Society of Photo-optical Instrumentation Engineers
Scholarly/refereed, author accepted manuscript
Copyright Society of Photo Optical Instrumentation Engineers (2013) Society of Photo Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
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Radiation-damaged nanodiamonds (NDs) are ideal optical contrast agents for photoacoustic (PA) imaging in biological tissues due to their good biocompatibility and high optical absorbance in the near-infrared (NIR) range. Acid treated NDs are oxidized to form carboxyl groups on the surface, functionalized with polyethylene glycol (PEG) and human epidermal growth factor receptor 2 (HER2) targeting ligand for breast cancer tumor imaging. Because of the specific binding of the ligand conjugated NDs to the HER2-overexpressing murine breast cancer cells (4T1.2 neu), the tumor tissues are significantly delineated from the surrounding normal tissue at wavelength of 820 nm under the PA imaging modality. Moreover, HER2 targeted NDs (HER2-PEG-NDs) result in higher accumulation in HER2 positive breast tumors as compared to non-targeted NDs after intravenous injection (i.v.). Longer retention time of HER-PEG-NDs is observed in HER2 overexpressing tumor model than that in negative tumor model (4T1.2). This demonstrates that targeting moiety conjugated NDs have great potential for the sensitive detection of cancer tumors and provide an attractive delivery strategy for anti-cancer drugs.
Zhang, Ti, Huizhong Cui, Chia-Yi Fang, Janggun Jo, Xinmai Yang, Huan-Cheng Chang, and M. Laird Forrest. "In Vivo Photoacoustic Imaging of Breast Cancer Tumor with HER2-targeted Nanodiamonds." Nanoimaging and Nanospectroscopy (2013): n. pag.
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