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Pharmaceutical Chemistry Scholarly Works: Recent submissions
Now showing items 241-260 of 358
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A Simple Protein Precipitation-based Simultaneous Quantification of Lovastatin and Its Active Metabolite Lovastatin Acid in Human Plasma by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry using Polarity Switching
(OMICS International, 2015-03-30)Lovastatin is an anti-cholesterol lactone drug indicated for the treatment of hyperlipidemia and to reduce the risk of coronary heart disease. It is converted to the β-hydroxy acid form (lovastatin acid) in vivo, which is ... -
Sarcoendoplasmic Reticulum Ca2+ ATPase. A Critical Target in Chlorine Inhalation–Induced Cardiotoxicity
(American Thoracic Society, 2015-04)Autopsy specimens from human victims or experimental animals that die due to acute chlorine gas exposure present features of cardiovascular pathology. We demonstrate acute chlorine inhalation–induced reduction in heart ... -
Visualization of the type III secretion sorting platform of Shigella flexneri
(National Academy of Sciences, 2015-01-27)Bacterial type III secretion machines are widely used to inject virulence proteins into eukaryotic host cells. These secretion machines are evolutionarily related to bacterial flagella and consist of a large cytoplasmic ... -
Vitamin D Receptor Gene Ablation in the Conceptus Has Limited Effects on Placental Morphology, Function and Pregnancy Outcome
(Public Library of Science, 2015-01-29)Vitamin D deficiency has been implicated in the pathogenesis of several pregnancy complications attributed to impaired or abnormal placental function, but there are few clues indicating the mechanistic role of vitamin D ... -
The effect of Vdr gene ablation on global gene expression in the mouse placenta
(Elsevier, 2015)The effects of vitamin D are mediated through the vitamin D receptor (VDR), a predominantly nuclear receptor, expressed in numerous tissues including the placenta. VDR and the retinoid X receptor (RXR) form a dimer complex ... -
Comparison of neostigmine induced reversal of vecuronium in normal weight, overweight and obese female patients
(Medknow Publications, 2015)Background and Aims: Obese patients are more vulnerable to residual neuromuscular block (NMB) and its associated complications in the post-operative period. This study was carried out to compare neostigmine induced reversal ... -
Broadly Protective Shigella Vaccine Based on Type III Secretion Apparatus Proteins
(American Society for Microbiology, 2012-03)Shigella spp. are food- and waterborne pathogens that cause severe diarrheal and dysenteric disease associated with high morbidity and mortality. Individuals most often affected are children under 5 years of age in the ... -
Impact of detergent on biophysical properties and immune response of the IpaDB fusion protein, a candidate subunit vaccine against Shigella species.
(American Society for Microbiology, 2014-11-03)Shigella spp. are causative agents of bacillary dysentery, a human illness with high global morbidity levels, particularly among elderly and infant populations. Shigella infects via the fecal-oral route, and its virulence ... -
Direct and Indirect Effects of Soluble Extracts of Schistosoma mansoni Eggs on Fibroblast Proliferation In Vitro
(American Society for Microbiology, 1982-10)The possibility that soluble products of Schistosoma mansoni eggs might participate in the pathogenesis of hepatic fibrosis in schistosomiasis was investigated. Both crude saline extracts of eggs (soluble egg antigen [SEA]) ... -
Evidence for Two Distinct CoA Binding Sites on Yeast alpha-Isopropylmalate Synthase
(American Society for Biochemistry and Molecular Biology, 1977) -
The conformation of nascent polylysine and polyphenylalanine peptides on ribosomes
(American Society for Biochemistry and Molecular Biology, 1991-01-25)Polypeptide synthesis using either phenylalanine or lysine was initiated on Escherichia coli ribosomes; then the position and conformation of the nascent peptide were monitored by fluorescence techniques. To this end, ... -
Structure-Function Analysis of Invasion Plasmid Antigen C (IpaC) from Shigella flexneri
(American Society for Biochemistry and Molecular Biology, 2002-11-08)Shigella flexneri causes a self-limiting gastroenteritis in humans, characterized by severe localized inflammation and ulceration of the colonic mucosa. Shigellosis most often targets young children in underdeveloped ... -
The Needle Component of the Type III Secreton of Shigella Regulates the Activity of the Secretion Apparatus
(American Society for Biochemistry and Molecular Biology, 2005-10)Gram-negative bacteria commonly interact with eukaryotic host cells by using type III secretion systems (TTSSs or secretons). TTSSs serve to transfer bacterial proteins into host cells. Two translocators, IpaB and IpaC, ... -
Self-chaperoning of the Type III Secretion System Needle Tip Proteins IpaD and BipD
(American Society for Biochemistry and Molecular Biology, 2007-02-09)Bacteria expressing type III secretion systems (T3SS) have been responsible for the deaths of millions worldwide, acting as key virulence elements in diseases ranging from plague to typhoid fever. The T3SS is composed of ... -
Identification of the MxiH Needle Protein Residues Responsible for Anchoring Invasion Plasmid Antigen D to the Type III Secretion Needle Tip
(American Society for Biochemistry and Molecular Biology, 2007-09-07)The pathogenesis of Shigella flexneri requires a functional type III secretion apparatus to serve as a conduit for injecting host-altering effector proteins into the membrane and cytoplasm of the targeted cell. The type ... -
Deoxycholate Interacts with IpaD of Shigella flexneri in Inducing the Recruitment of IpaB to the Type III Secretion Apparatus Needle Tip
(American Society for Biochemistry and Molecular Biology, 2008-05-01)Type III secretion (TTS) is an essential virulence function for Shigella flexneri that delivers effector proteins that are responsible for bacterial invasion of intestinal epithelial cells. The Shigella TTS apparatus (TTSA) ... -
Structural Characterization of the N Terminus of IpaC from Shigella flexneri
(American Society for Microbiology, 2003-03)The primary effector for Shigella invasion of epithelial cells is IpaC, which is secreted via a type III secretion system. We recently reported that the IpaC N terminus is required for type III secretion and possibly other ... -
Soluble invasion plasmid antigen C (IpaC) from Shigella flexneri elicits epithelial cell responses related to pathogen invasion
(American Society for Microbiology, 1996-10)Shigella flexneri invades colonic epithelial cells by pathogen-induced phagocytosis. The three proposed effectors of S. flexneri internalization are invasion plasmid antigens B (IpaB), IpaC, and IpaD, which are encoded on ... -
Shigella flexneri 2a Strain CVD 1207, with Specific Deletions in virG, sen, set, and guaBA, Is Highly Attenuated in Humans
(American Society for Microbiology, 2000-03)