ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
Molecular Biosciences: Recent submissions
Now showing items 421-440 of 887
-
Novel effects of ouabain in autosomal dominant polycystic kidney disease cystogenesis
(University of Kansas, 2013-08-31)Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in Pkd1 or Pkd2, genes encoding for polycystin-1 (PC-1) and polycystin-2 (PC-2), respectively. ADPKD is characterized by the progressive growth ... -
Changes in Cortical Connectivity and Gene Expression of the Rostral Forelimb Area After Ischemic Infarct in Motor Cortex in the Rat
(University of Kansas, 2013-08-31)Stroke is a large and growing problem in the United States. There are 795,000 incidences each year, and most are new incidences. Survivors are left with lasting functional deficits, and therefore stroke is one of the leading ... -
Ewing's Sarcoma EWS protein regulates skeletogenesis by modulation of SOX9
(University of Kansas, 2013-05-31)Ewing sarcoma is the second most common form of bone cancer in adolescents, characterized by the presence of an aberrant chimeric fusion gene EWS/FLI1. Wildtype EWS has been proposed to play a role in splicing and ... -
Novel roles for CD23, CTLA-4 and lipoproteins in human T cell function and differentiation
(University of Kansas, 2014-05-31)The differentiation of multipotent naïve T cells is influenced by the microenvironment. Cytokines, costimulatory proteins and other biological factors can tune this differentiation process, influencing cell fate. Controlling ... -
Mechanisms of structural plasticity in mature sensory axons: Role of BMP4 in female reproductive tract
(University of Kansas, 2013-05-31)Structural changes in sensory axons are associated with many peripheral nerve disorders. Degenerative loss or excessive sprouting of axons are hallmarks of sensory neuropathies or hyperinnervating pain syndromes respectively. ... -
Structural and Biochemical Investigations of the Heme Loading Mechanisms in Hemophores HasAp from Pseudomonas aeruginosa and HasAyp from Yersinia pestis
(University of Kansas, 2014-05-31)Under iron-limiting conditions, several Gram-negative pathogens secrete hemophore (HasA) protein that binds heme and deliver it to the outer membrane receptors in bacteria. Hemophore proteins have been structurally and ... -
Regulation of telomerase reverse transcriptase expression in Schizosaccharomyces pombe
(University of Kansas, 2013-12-31)Eukaryotic cells undergo chromosome shortening during each cell division due to the inability of DNA polymerase to replicate chromosome ends. This end replication problem is counteracted by the ribonucleoprotein telomerase, ... -
pH-Triggered Membrane Insertion of Proteins
(University of Kansas, 2015-05-31)Several classes of membrane proteins refold from their original soluble conformations in response to acidification and insert into lipid bilayers. Despite the recent advances in unraveling the molecular mechanisms of ... -
REGULATION OF ALC1'S SNF2 ATPASE: INTERPLAY BETWEEN THE SNF2 DOMAIN, THE MACRODOMAIN AND OTHER CONSERVED ELEMENTS
(University of Kansas, 2015-05-31)ALC1, also known as CHD1L, was originally identified as a gene present on a human chromosome 1q21 region amplified in ~50% of human hepatocellular carcinomas (HCC). ALC1 overexpressing cells form tumors in nude mice, and ... -
MicroRNA Sequencing of Long-Term Estrogen Deprived Breast Cancer Cells Reveals a Potential Role for miR-181a in Estrogen-Independent Growth
(University of Kansas, 2015-05-31)Breast cancer is a genetically complex disease that affects over 230,000 people in the U.S. every year. Estrogen signaling has been shown to play a large role in the development and progression of breast tumors that express ... -
Targeting the adaptability of heterogeneous aneuploidy population
(University of Kansas, 2015-05-31)Aneuploid genomes, characterized by unbalanced and diverse chromosome stoichiometry (karyotype), are associated with cancer malignancy and drug-resistance of human pathogenic fungi. My PhD projects studied three aspects ... -
An Automated Image-Based Method for Rapid Analysis of Chlamydia Infection as a Tool for Screening Antichlamydial Agents
(American Society for Microbiology, 2012-05-10)A major limitation in the identification of novel antichlamydial compounds is the paucity of effective methods for large-scale compound screening. The immunofluorescence assay is the preferred approach for accurate ... -
Concurrent CD44s and STAT3 expression in human clear cell renal cellular carcinoma and its impact on survival
(e-Century Publishing, 2014)Although CD44 was overexpressed and considered as a useful prognostic marker in renal cell carcinoma, the prognostic role of CD44s in clear cell renal cell carcinoma (ccRCC) remains controversial. Moreover, the correlation ... -
Local packing modulates diversity of iron pathways and cooperative behavior in eukaryotic and prokaryotic ferritins
(American Institute of Physics, 2014)Ferritin-like molecules show a remarkable combination of the evolutionary conserved activity of iron uptake and release that engage different pores in the conserved ferritin shell. It was hypothesized that pore selection ... -
Structure of an Aspergillus fumigatus old yellow enzyme (EasA) involved in ergot alkaloid biosynthesis
(International Union of Crystallography, 2014-10-08)The Aspergillus fumigatus old yellow enzyme (OYE) EasA reduces chanoclavine-I aldehyde to dihydrochanoclavine aldehyde and works in conjunction with festuclavine synthase at the branchpoint for ergot alkaloid pathways. The ... -
SUMOylation of Psmd1 Controls Adrm1 Interaction with the Proteasome
(Elsevier, 2014-06-05)SUMOylation is the covalent conjugation of SUMO polypeptides to cellular target proteins. Psmd1 is a subunit of the proteasomal 19S regulatory particle that acts as a docking site for Adrm1, another proteasome subunit that ... -
A Mutation in the DNA Polymerase Accessory Factor of Herpes Simplex Virus 1 Restores Viral DNA Replication in the Presence of Raltegravir
(American Society for Microbiology, 2014-10)Previous reports showed that raltegravir, a recently approved antiviral compound that targets HIV integrase, can inhibit the nuclease function of human cytomegalovirus (HCMV terminase) in vitro. In this study, subtoxic ... -
Lipopolysaccharide-Binding Alkylpolyamine DS-96 Inhibits Chlamydia trachomatis Infection by Blocking Attachment and Entry
(American Society for Microbiology, 2014-03-24)Vaginally delivered microbicides are being developed to offer women self-initiated protection against transmission of sexually transmitted infections such as Chlamydia trachomatis. A small molecule, DS-96, rationally ... -
An analysis of the requirement for septate junction proteins in essential morphogenetic events
(University of Kansas, 2015-08-31)Proper organismal development depends upon highly regulated cellular rearrangements and cell shape changes that are driven by intrinsic stabilizing and dynamic forces within an epithelium. These morphological processes ... -
Engineering GFP-Family Member Protiens to Achieve Novel Functions: A Class of Proteins Limited Only by the Imagination
(University of Kansas, 2015-05-31)The Green Fluorescent Protein (GFP) has single handedly revolutionized microscopy and molecular biology. A simple search for GFP in the NCBI Pubmed database yields over 29,900 unique publications as of April 2015 demonstrating ...