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    Concurrent CD44s and STAT3 expression in human clear cell renal cellular carcinoma and its impact on survival

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    Qin_CD44s_2014.pdf (663.9Kb)
    Issue Date
    2014
    Author
    Qin, Jun
    Yang, Bo
    Xu, Bao-Qin
    Smithc, Amber
    Xu, Liang
    Yuan, Jian-Lin
    Li, Ling
    Publisher
    e-Century Publishing
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
    Published Version
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097256/
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    Abstract
    Although CD44 was overexpressed and considered as a useful prognostic marker in renal cell carcinoma, the prognostic role of CD44s in clear cell renal cell carcinoma (ccRCC) remains controversial. Moreover, the correlation and prognostic significance of CD44s and its downstream signaling target pSTAT3 are unclear in ccRCC. In this study, 75 pairs of carcinoma and paired adjacent non-tumor renal tissue samples were collected from patients with localized ccRCC who underwent a nephrectomy. The expression levels of CD44s and pSTAT3 were analyzed using immunohistochemistry. Correlations between CD44s/pSTAT3 expression and clinical and pathological characteristics were determined using x2 test, Kaplan-Meier analysis and Cox’s proportional hazards model. We found that CD44s is highly expressed in 46.67% of tumor tissues, and its high expression was significantly associated with high tumor grade (P < 0.001), large tumor size (P = 0.009) and advanced T stage (P = 0.004). A strong correlation exists between high expression of CD44s and pSTAT3 (r = 0.4013, P = 0.0004). The joint over expression of CD44s and pSTAT3 was present in 42.66% of tumor specimens and had an additive negative impact on overall survival. Patients with CD44shighpSTAT3high expression had significantly poor survival as compared to patients with CD44slowpSTAT3low tumor expression (P = 0.024), though the concurrent overexpression of CD44s and pSTAT3 was not an independent prognostic factor for overall survival. Our data indicate that expression of both CD44s and pSTAT3 in ccRCC is associated with advanced tumor stage and patient survival. The conclusions from this study may improve the prediction of ccRCC prognosis information when CD44s and pSTAT3 expression are evaluated together with classical clinicopathological parameters.
    Description
    This is the published version.
    URI
    http://hdl.handle.net/1808/19336
    Collections
    • Molecular Biosciences Scholarly Works [573]
    Citation
    Qin et. al. "Concurrent CD44s and STAT3 expression in human clear cell renal cellular carcinoma and its impact on survival." International Journal of Clinical and Experimental Pathology (2014): v7(6). www.ijcep.com

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    KU Libraries
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    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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