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    Changes in Cortical Connectivity and Gene Expression of the Rostral Forelimb Area After Ischemic Infarct in Motor Cortex in the Rat

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    Urban_ku_0099D_12957_DATA_1.pdf (14.86Mb)
    Issue Date
    2013-08-31
    Author
    Urban, Edward Theodore Richard
    Publisher
    University of Kansas
    Format
    240 pages
    Type
    Dissertation
    Degree Level
    Ph.D.
    Discipline
    Molecular & Integrative Physiology
    Rights
    Copyright held by the author.
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    Abstract
    Stroke is a large and growing problem in the United States. There are 795,000 incidences each year, and most are new incidences. Survivors are left with lasting functional deficits, and therefore stroke is one of the leading causes of adult disability in humans. Some function is regained that was lost to stroke, and this recovery is correlated to physiological reorganization. That is to say, after stroke the brain functions differently. The physiological reorganization may be based on anatomical reorganization. If this is true, the brain acts differently, because it is wired differently after stroke. The anatomical reorganization may be based on expression differences; thus, leading to the conclusion that the brain is wired differently because genes were expressed in different ways after the stroke. The series of studies within this dissertation lead the reader down this train of thought and show evidence for it by using adult rats in a model of ischemic injury to the cortex, and compare the connectivity and gene expression patterns of lesioned brains to non-lesioned brains.
    URI
    http://hdl.handle.net/1808/19624
    Collections
    • Dissertations [4454]
    • Molecular Biosciences Dissertations and Theses [270]

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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