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    An analysis of the requirement for septate junction proteins in essential morphogenetic events

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    Hall_ku_0099D_14190_DATA_1.pdf (64.62Mb)
    Issue Date
    2015-08-31
    Author
    Hall, Sonia Marie
    Publisher
    University of Kansas
    Format
    142 pages
    Type
    Dissertation
    Degree Level
    Ph.D.
    Discipline
    Molecular Biosciences
    Rights
    Copyright held by the author.
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    Abstract
    Proper organismal development depends upon highly regulated cellular rearrangements and cell shape changes that are driven by intrinsic stabilizing and dynamic forces within an epithelium. These morphological processes require coordination of signaling pathways, cytoskeletal changes, and cell adhesion. To identify essential regulators of morphogenesis, our lab conducted three screens to identify genes involved in regulating morphogenesis. From this screen, we identified a novel component of the septate junction (SJ), Macroglobulin complement related (Mcr). The SJ provides a barrier between epithelial cells to regulate paracellular flow, allowing for organ compartmentalization. The SJ requires over twenty proteins for its organization and function. While the function of the SJ is of critical importance to development and homeostasis, its role in morphogenesis was unclear. We examined whether the identification of Mcr in a screen for morphogenesis was an isolated role of Mcr or a concerted requirement for the entire SJ complex. To explore this question, we conducted an analysis of nine SJ genes and examined the penetrance of defects in head involution, dorsal closure, and salivary gland organogenesis. From this analysis, we determined that each SJ component examined has an essential role in regulating morphogenesis by contributing to cell shape changes and rearrangements.
    URI
    http://hdl.handle.net/1808/19189
    Collections
    • Molecular Biosciences Dissertations and Theses [182]
    • Dissertations [3958]

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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