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Molecular Biosciences: Recent submissions
Now showing items 341-360 of 887
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An Investigation of the Catalytic Mechanism of S-adenosylmethionine Synthetase by QM/MM Calculations
(Elsevier, 2010-12-01)Catalysis by S-adenosylmethionine synthetase has been investigated by quantum mechanical/molecular mechanical calculations, exploiting structures of the active crystalline enzyme. The transition state energy of +19.1 ... -
Development of a novel cell-based assay to monitor the transactivation activity of the HSV-1 protein ICP0
(Elsevier Masson, 2016-08-01)The herpes simplex virus type 1 (HSV-1) immediate-early phosphoprotein infected cell protein 0 (ICP0) is a potent transcriptional activator of viral genes and is required for efficient viral replication and reactivation ... -
CK2 Inhibitors Increase the Sensitivity of HSV-1 to Interferon-β
(Elsevier Masson, 2012-09-01)Herpes simplex virus type 1 (HSV-1) requires the activities of cellular kinases for efficient replication. The host kinase, CK2, has been shown or is predicted to modify several HSV-1 proteins and has been proposed to ... -
Lantibiotic Smb: Characterization of the immunity protein, identification of a novel receptor-like protein, and a new perspective on regulation
(University of Kansas, 2014-05-31)Dental caries, commonly known as tooth decay, is a chronic disease that develops slowly and requires formation of biofilm on tooth surfaces, commonly known as dental plaque. Dental plaque is a highly complex multispecies ... -
IDENTIFICATION OF THE RNA BINDING PROTEIN RBM3 AS A NOVEL EFFECTOR OF β-CATENIN SIGNALING AND COLON CANCER STEM CELLS
(University of Kansas, 2014-05-31)The intestinal epithelium is one of the fastest renewing tissues within the adult. This renewal is primarily driven by the intestinal epithelial stem cell compartment and homeostasis of this compartment needs to be strictly ... -
A characterization of deficits associated with loss of NCB5OR in the mouse brain
(University of Kansas, 2016-05-31)The simplest approach to the study of an event is to first consider that of the simplest cause. When investigating the mechanisms governing idiopathic diseases, this generally takes the form of an ab initio genetic approach, ... -
PARACELLULAR EPITHELIAL TRANSPORT MAXIMIZES ENERGY EFFICIENCY IN THE KIDNEY
(University of Kansas, 2016-08-31)Claudins are tight junction transmembrane proteins that act as paracellular ion channels. The proximal renal tubule reabsorbs 70% of glomerulus-filtered Na+. Of this Na+, up to 1/3 is reabsorbed passively via the paracellular ... -
PROTEOSTASIS IN BUDDING YEAST
(University of Kansas, 2016-08-31)Cells utilize an array of quality control mechanisms to maintain a stable and functional proteome. These protein homeostasis mechanisms counteract the constant challenges of protein damages through an integrated network ... -
A genomic analysis of meiosis in Drosophila melanogaster
(University of Kansas, 2016-05-31)Meiosis is a specialized form of cell division in which a single diploid cell undergoes one round of genome duplication followed by two rounds of cell division to produce four haploid gametes. In most organisms, including ... -
SUMOylation at the centromere: The role of SUMOylation of the DNA topoisomerase IIα C-terminal domain in the regulation of mitotic kinases in cell cycle progression.
(University of Kansas, 2016-08-31)In many model systems, SUMOylation is required for proper mitosis; in particular, chromosome segregation during anaphase. It was previously shown that interruption of SUMOylation through the addition of the dominant negative ... -
NMR studies of molecular interactions involved in the type III secretion system, SUMOylation, and the RNA binding protein HuR
(University of Kansas, 2016-08-31)Proteins are one of the most intriguing, versatile, and complex macromolecules in living systems. Proteins rarely function independently and perform their activities through a multitude of interactions with other proteins ... -
New roles for Hox and Wnt in Cell Migration
(University of Kansas, 2016-08-31)Neuron migration is a critical process during central nervous system development. In the dissertation below I report new roles for established genes such as Wnt and Hox, and describe roles for several new genes in neuron ... -
THE COMPLEX GENETICS OF LIFESPAN AND XENOBIOTIC RESISTANCE IN DROSOPHILA MELANOGASTER
(University of Kansas, 2016-08-31)It is constantly observed that populations of species, like the DSPR, harbor considerable genetic variation for phenotypic traits. However, our understanding of the location, effect, and frequency of alleles that create ... -
Genetic Control of Tissue Specific Growth in the Drosophila Trachea
(University of Kansas, 2016-08-31)In most organisms, different tissues and organs grow at different rates relative to each other, suggesting underlying growth mechanisms that act tissue specifically. The mechanisms of tissue specific growth are less well ... -
The C. elegans ephrin EFN-4 functions non-cell autonomously with heparan sulfate proteoglycans to promote axon outgrowth and branching
(2015-07-17)The Eph receptors and their cognate ephrin ligands play key roles in many aspects of nervous system development. These interactions typically occur within an individual tissue type, serving either to guide axons to their ... -
Stress‐response balance drives the evolution of a network module and its host genome
(Wiley Open Access, 2015-08-01)Stress response genes and their regulators form networks that underlie drug resistance. These networks often have an inherent tradeoff: their expression is costly in the absence of stress, but beneficial in stress. They ... -
Spatial regulation of a common precursor from two distinct genes generates metabolite diversity
(Royal Society of Chemistry, 2015-07-13)In secondary metabolite biosynthesis, core synthetic genes such as polyketide synthase genes usually encode proteins that generate various backbone precursors. These precursors are modified by other tailoring enzymes to ... -
γ-Tubulin complexes in microtubule nucleation and beyond
(The American Society For Cell Biology, 2015-07-02)Tremendous progress has been made in understanding the functions of γ-tubulin and, in particular, its role in microtubule nucleation since the publication of its discovery in 1989. The structure of γ-tubulin has been ... -
Oligopolyphenylenevinylene-Conjugated Oligoelectrolyte Membrane Insertion Molecules Selectively Disrupt Cell Envelopes of Gram-Positive Bacteria
(American Society for Microbiology, 2015-01-09)The modification of microbial membranes to achieve biotechnological strain improvement with exogenous small molecules, such as oligopolyphenylenevinylene-conjugated oligoelectrolyte (OPV-COE) membrane insertion molecules ... -
Pheromone killing of multidrug-resistant Enterococcus faecalis V583 by native commensal strains
(National Academy of Sciences, 2015)Multidrug-resistant Enterococcus faecalis possess numerous mobile elements that encode virulence and antibiotic resistance traits as well as new metabolic pathways, often constituting over one-quarter of the genome. It was ...