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Molecular Biosciences: Recent submissions
Now showing items 361-380 of 887
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Herpes Simplex Virus 1 Upregulates p 35, Alters CDK-5 Localization, and Stimulates CDK-5 Kinase Activity during Acute Infection in Neurons
(American Society for Microbiology, 2015-05)The cyclin-dependent kinase 5 (CDK-5) activating protein, p35, is important for acute herpes simplex virus 1 (HSV-1) replication in mice. This report shows that HSV-1 increases p35 levels, changes the primary localization ... -
1.65 Å resolution structure of the AraC-family transcriptional activator ToxT from Vibrio cholerae
(International Union of Crystallography, 2016-08-26)ToxT is an AraC-family transcriptional activator protein that controls the expression of key virulence factors in Vibrio cholerae, the causative agent of cholera. ToxT directly activates the expression of the genes that ... -
Studies on Antioxidant induced giantism and cannibalism of the ciliated protozoan, Blepharisma americanum (Suzuki, 1954)
(University of Kansas, 1981) -
Some studies on the morphology of B. coli
(University of Kansas, 1929) -
You are lost without a map: Navigating the sea of protein structures
(Elsevier, 2015-04)X-ray crystal structures propel biochemistry research like no other experimental method, since they answer many questions directly and inspire new hypotheses. Unfortunately, many users of crystallographic models mistake ... -
Transmembrane Complexes of DAP12 Crystallized in Lipid Membranes Provide Insights into Control of Oligomerization in Immunoreceptor Assembly
(Elsevier, 2015-05-26)The membrane-spanning α helices of single-pass receptors play crucial roles in stabilizing oligomeric structures and transducing biochemical signals across the membrane. Probing intermolecular transmembrane interactions ... -
INVESTIGATING THE PRESENCE OF MITOCHONDRIAL DNA METHYLATION, ITS ALTERATION AND ASSOCIATION WITH MITOCHONDRIAL TRANSCRIPTION AND MITOCHONDRIAL FUNCTION
(University of Kansas, 2015-12-31)Mitochondrial proteins are encoded by both the nuclear and mitochondrial genome (mtDNA). Thus, alterations in mtDNA affect mitochondrial function and are involved in a plethora of diseases associated with mitochondrial ... -
Ewsa-dependent regulation of Runx2 during zebrafish skeletogenesis
(University of Kansas, 2016-05-31)Ewing’s sarcoma is the second most common malignant bone cancer found in adolescents, and the genetic hallmark of this disease is the presence of the aberrant chimeric fusion protein EWS/FLI1. This fusion is induced by the ... -
Heterogeneity and Decision-Making in Cellular Signaling Networks
(University of Kansas, 2016-05-31)Signaling networks are the means by which cells adapt to their environment. Over the last decade, cellular decision-making has been shown to exist in the midst of substantial heterogeneity, even among isogenic cells. The ... -
SUMOylation in centromere organization: Regulation of a putative chromatin remodeler, Polo-like kinase 1 interacting checkpoint helicase (PICH) by mitotic SUMOylation
(University of Kansas, 2016-05-31)SUMOylation is a posttranslational modification that can mediate diverse cellular processes such as DNA replication, transcription, DNA repair, cell cycle regulation, signal transduction and cell death. Similar to ... -
ELUCIDATION OF THE NEEDLE-TIP AND TIP-TRANSLOCON INTERACTIONS OF THE SALMONELLA SPI-1 TYPE III SECRETION SYSTEM AND IDENTIFICATION OF SMALL MOLECULE BINDERS OF THE TIP AND TRANSLOCON PROTEINS
(University of Kansas, 2016-05-31)The type III secretion system (T3SS) is required by many pathogenic Gram-negative bacteria for the initiation and maintenance of infections within eukaryotic host cells. T3SS harboring bacteria include the causative agents ... -
Pocket optimization and its application to identify small-molecule inhibitors of protein-protein interactions
(University of Kansas, 2016-05-31)Because of their ubiquitous nature in many cellular processes, modulating protein-protein interactions offers tremendous therapeutic potential. However, protein-protein interactions remain a difficult class of drug targets, ... -
Role of Zinc in Parkin RING2 E3 Ubiquitin Ligase Ubiquitination
(University of Kansas, 2016-05-31)In common neurodegenerative diseases among older adults, Parkinson’s disease (PD) ranks the second after Alzheimer’s disease. Symptoms of Parkinson’s disease are shaking, slowness of movement, rigidity of the extremities ... -
Development of protein-protein docking methodology and benchmarking environment
(University of Kansas, 2016-05-31)Structural characterization of proteins is essential for understanding life processes at the molecular level. However, only a fraction of known proteins have experimentally determined structures. That fraction is even ... -
The effect of certain amino acids on the growth of certain bacteria
(University of Kansas, 1928) -
Quantum-Classical Reentrant Relaxation Crossover in Dy2Ti2O7 Spin Ice
(American Physical Society, 2003-09-05)We have studied spin relaxation in the spin ice compound Dy2Ti2O7 through measurements of the ac magnetic susceptibility. While the characteristic spin-relaxation time (τ) is thermally activated at high temperatures, it ... -
Quantum and thermal spin relaxation in the diluted spin ice Dy2−xMxTi2O7 (M=Lu,Y)
(American Physical Society, 2004-11-23)We have studied the low-temperature ac magnetic susceptibility of the diluted spin ice compound Dy2−xMxTi2O7, where the magnetic Dy ions on the frustrated pyrochlore lattice have been replaced with nonmagnetic ions, M=Y ... -
Low-temperature spin freezing in the Dy2Ti2O7 spin ice
(American Physical Society, 2004-02-18)We report a study of the low temperature bulk magnetic properties of the spin ice compound Dy2Ti2O7 with particular attention to the (T<4K) spin freezing transition. While this transition is superficially similar to that ... -
Giant Anharmonicity and Nonlinear Electron-Phonon Coupling in MgB2: A Combined First-Principles Calculation and Neutron Scattering Study
(American Physical Society, 2001-03-22)First-principles calculations of the electronic band structure and lattice dynamics for the new superconductor MgB2 are carried out and found to be in excellent agreement with our inelastic neutron scattering measurements. ... -
Dirty spin ice: The effect of dilution on spin freezing in Dy2Ti2O7
(American Physical Society, 2002-08-30)We have studied spin freezing in the diluted spin ice compound Dy2−xYxTi2O7 where the nonmagnetic Y ions replace the magnetic Dy ions on the frustrated pyrochlore lattice. Magnetic ac and dc susceptibility data are presented ...