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    Pheromone killing of multidrug-resistant Enterococcus faecalis V583 by native commensal strains

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    Hancock_2015.pdf (1.071Mb)
    Issue Date
    2015
    Author
    Gilmore, Michael S.
    Rauch, Marcus
    Ramsey, Matthew M.
    Himes, Paul R.
    Varahan, Sriram
    Manson, Janet M.
    Lebreton, Francois
    Hancock, Lynn E.
    Publisher
    National Academy of Sciences
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
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    Abstract
    Multidrug-resistant Enterococcus faecalis possess numerous mobile elements that encode virulence and antibiotic resistance traits as well as new metabolic pathways, often constituting over one-quarter of the genome. It was of interest to determine how this large accretion of mobile elements affects competitive growth in the gastrointestinal (GI) tract consortium. We unexpectedly observed that the prototype clinical isolate strain V583 was actively killed by GI tract flora, whereas commensal enterococci flourished. It was found that killing of V583 resulted from lethal cross-talk between accumulated mobile elements and that this cross-talk was induced by a heptapeptide pheromone produced by native E. faecalis present in the fecal consortium. These results highlight two important aspects of the evolution of multidrug-resistant enterococci: (i) the accretion of mobile elements in E. faecalis V583 renders it incompatible with commensal strains, and (ii) because of this incompatibility, multidrug-resistant strains sharing features found in V583 cannot coexist with commensal strains. The accumulation of mobile elements in hospital isolates of enterococci can include those that are inherently incompatible with native flora, highlighting the importance of maintaining commensal populations as means of preventing colonization and subsequent infection by multidrug-resistant strains.
    URI
    http://hdl.handle.net/1808/22135
    DOI
    https://doi.org/10.1073/pnas.1500553112
    Collections
    • Molecular Biosciences Scholarly Works [581]
    Citation
    Gilmore, M. S., Rauch, M., Ramsey, M. M., Himes, P. R., Varahan, S., Manson, J. M., … Hancock, L. E. (2015). Pheromone killing of multidrug-resistant Enterococcus faecalis V583 by native commensal strains . Proc Natl Acad Sci USA, 112(23), 7273–7278. doi:10.1073/pnas.1500553112

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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