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    γ-Tubulin complexes in microtubule nucleation and beyond

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    Oakley_2015_MBoC.pdf (244.2Kb)
    Issue Date
    2015-07-02
    Author
    Oakley, Berl R.
    Paolillo, Vitoria
    Zheng, Yixian
    Publisher
    The American Society For Cell Biology
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
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    Abstract
    Tremendous progress has been made in understanding the functions of γ-tubulin and, in particular, its role in microtubule nucleation since the publication of its discovery in 1989. The structure of γ-tubulin has been determined, and the components of γ-tubulin complexes have been identified. Significant progress in understanding the structure of the γ-tubulin ring complex and its components has led to a persuasive model for how these complexes nucleate microtubule assembly. At the same time, data have accumulated that γ-tubulin has important but less well understood functions that are not simply a consequence of its function in microtubule nucleation. These include roles in the regulation of plus-end microtubule dynamics, gene regulation, and mitotic and cell cycle regulation. Finally, evidence is emerging that γ-tubulin mutations or alterations of γ-tubulin expression play an important role in certain types of cancer and in other diseases.
    URI
    http://hdl.handle.net/1808/22198
    DOI
    https://doi.org/10.1091/mbc.E14-11-1514
    Collections
    • Molecular Biosciences Scholarly Works [458]
    Citation
    Oakley, B. R., Paolillo, V., & Zheng, Y. (2015).  y-Tubulin complexes in microtubule nucleation and beyond. Molecular Biology of the Cell, 26(17), 2957–2962. doi:10.1091/mbc.e14-11-1514

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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