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Molecular Biosciences: Recent submissions
Now showing items 321-340 of 887
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The Bacterial Type III Secretion System as a Target for Developing New Antibiotics
(wiley, 2014-12-17)Antibiotic resistance in pathogens requires new targets for developing novel antibacterials. The bacterial type III secretion system (T3SS) is an attractive target for developing antibacterials as it is essential in the ... -
Chondroinductive Hydrogel Pastes Composed of Naturally Derived Devitalized Cartilage
(Springer Verlag, 2016-06)Hydrogel precursors are liquid solutions that are prone to leaking from the defect site once implanted in vivo. Therefore, the objective of the current study was to create a hydrogel precursor that exhibited a yield stress. ... -
NMR Identification of the Binding Surfaces Involved in the Salmonella and Shigella Type III Secretion Tip-Translocon Protein-Protein Interactions
(Wiley, 2016-08)The type III secretion system (T3SS) is essential for the pathogenesis of many bacteria including Salmonella and Shigella, which together are responsible for millions of deaths worldwide each year. The structural component ... -
NMR characterization of the Type III Secretion System Tip Chaperone Protein PcrG of Pseudomonas aeruginosa
(Biochemistry, 2015-11-03)Lung infection with Pseudomonas aeruginosa is the leading cause of death among cystic fibrosis patients. To initiate infection, P. aeruginosa assembles a protein nanomachine, the type III secretion system (T3SS) to inject ... -
Optogenetic inhibitor of the transcription factor CREB
(Elsevier, 2016-11-19)Current approaches for optogenetic control of transcription do not mimic the activity of endogenous transcription factors, which act at numerous sites in the genome in a complex interplay with other factors. Optogenetic ... -
Choice of resident costimulatory molecule can influence cell fate in human naïve CD4+ T cell differentiation
(Elsevier, 2011-08-27)With antigen stimulation, naïve CD4+ T cells differentiate to several effector or memory cell populations, and cytokines contribute to differentiation outcome. Several proteins on these cells receive costimulatory signals, ... -
Characterization of thromboxane A2 receptor and TRPV1 mRNA expression in cultured sensory neurons
(Elsevier, 2012-04-25)Thromboxane A2 (TxA2) is an arachidonic acid metabolite that stimulates platelet aggregation and vasoconstriction when released from platelets and other cell types during tissue trauma. More recent research has demonstrated ... -
More than two decades of Apc modeling in rodents
(Elsevier, 2013-01-17)Mutation of tumor suppressor gene adenomatous polyposis coli (APC) is an initiating step in most colon cancers. This review summarizes Apc models in mice and rats, with particular concentration on those most recently ... -
Studies in bacterial association
(University of Kansas, 1931) -
Cytological and bacteriological aspects of refrigerator slime
(University of Kansas, 1930) -
Breaking a pathogen’s iron will: inhibiting siderophore production as an antimicrobial strategy
(Elsevier, 2015-05-10)The rise of antibiotic resistance is a growing public health crisis. Novel antimicrobials are sought, preferably developing nontraditional chemical scaffolds that do not inhibit standard targets such as cell wall synthesis ... -
Branched amphiphilic peptide capsules: Cellular uptake and retention of encapsulated solutes
(Elsevier, 2014-02-22)Branched amphiphilic peptide capsules (BAPCs) are peptide nanospheres comprised of equimolar proportions of two branched peptide sequences bis(FLIVI)-K-KKKK and bis(FLIVIGSII)-K-KKKK that self-assemble to form bi-layer ... -
Interactions of Bordetella pertussis adenylyl cyclase toxin CyaA with calmodulin mutants and calmodulin antagonists: Comparison with membranous adenylyl cyclase I
(Elsevier, 2012-01-13)The adenylyl cyclase (AC) toxin CyaA from Bordetella pertussis constitutes an important virulence factor for the pathogenesis of whooping cough. CyaA is activated by calmodulin (CaM) and compromises host defense by excessive ... -
Structure-Activity Relationships for the Interactions of 2’- and 3’-(O)-(N-Methyl)anthraniloyl-Substituted Purine and Pyrimidine Nucleotides with Mammalian Adenylyl Cyclases
(Elsevier, 2011-05-18)Membranous adenylyl cyclases (ACs) play a key role in signal transduction and are promising drug targets. In previous studies we showed that 2’,3’-(O)-(N-methylanthraniloyl) (MANT)-substituted nucleotides are potent AC ... -
Distinct Interactions of 2′- and 3′-O-(N-Methyl)anthraniloyl-Isomers of ATP and GTP with the Adenylyl Cyclase Toxin of Bacillus anthracis, Edema Factor
(Elsevier, 2009-08-01)Anthrax disease is caused by the spore-forming bacterium, Bacillus anthracis. Bacillus anthracis produces a calmodulin-activated adenylyl cyclase (AC) toxin, edema factor (EF). Through excessive cAMP accumulation EF disrupts ... -
Differential Interactions of the Catalytic Subunits of Adenylyl Cyclase with Forskolin Analogs
(Elsevier, 2009-04-02)The diterpene forskolin (FS) binds to, and activates, mammalian membranous adenylyl cyclase (AC) isoforms I–VIII. Diterpenes without C1-OH group do not activate ACs. The C1-OH group forms a hydrogen bond with the backbone ... -
Studies on pernicious anemia
(University of Kansas, 1929) -
Redesign of MST enzymes to target lyase activity instead promotes mutase and dehydratase activities
(Elsevier, 2013-09-19)The isochorismate and salicylate synthases are members of the MST family of enzymes. The isochorismate synthases establish an equilibrium for the conversion chorismate to isochorismate and the reverse reaction. The salicylate ... -
Lysine221 is the general base residue of the isochorismate synthase from Pseudomonas aeruginosa (PchA) in a reaction that is diffusion limited
(Elsevier, 2013-08-11)The isochorismate synthase from Pseudomonas aeruginosa (PchA) catalyzes the conversion of chorismate to isochorismate, which is subsequently converted by a second enzyme (PchB) to salicylate for incorporation into the ...