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Pharmaceutical Chemistry Dissertations and Theses: Recent submissions
Now showing items 81-100 of 141
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Fluorogenic and Affinity Derivatization Methods to Enable Proteomic Study of 3-Nitrotyrosine and 3,4-Dihydroxyphenylalanine as Markers of Oxidative Stress
(University of Kansas, 2013-08-31)Purpose: Oxidative post-translational modification of protein-bound tyrosine residues can have a significant impact on protein structure and function and thus may be important to physiological and pathological processes. ... -
Applicability of Using Physical Stability Data and Advanced Visualization Methods in Protein Comparability Studies
(University of Kansas, 2013-12-31)Comparability assessments are frequently performed during biopharmaceutical drug development to evaluate the effects of manufacturing process changes on the structural integrity, safety and efficacy of candidate protein ... -
Synthesis and Characterization of MOG-IDAC and PLP-PEG-B7AP Molecules for Efficacy Evaluation in the EAE mouse model
(University of Kansas, 2012-05-31)Synthesis, Formulation, and In vivo Evaluation of MOG-PEG-IDAC and PLP-PEG-B7AP for Targeting APC to Suppress EAE John M. Stewart, Crisandra Wilkie, Barlas Buyuktimkin, Ahmed Badawi, Paul Kiptoo, and Teruna J. Siahaan ... -
Determination of Absolute Protein Content of Hepatic CYP4F Enzymes in Human Liver Microsomes Using LC/MS/MS Methodology and Comparison with Immunoquantification and Enzyme Activity
(University of Kansas, 2013-08-31)The purpose of the work presented herein was to determine the absolute protein content of multiple cytochrome P450 (CYP) enzymes in individual donor human liver microsome (HLM) samples. The CYP4F subfamily of enzymes have ... -
Water Content Determination of Rubber Stoppers Utilized for Sealing Lyophilized Pharmaceutical Products: Assessment of Two Karl Fischer Titration Methods
(University of Kansas, 2013-08-31)In the pharmaceutical industry, the success of a new drug product is strongly impacted by the stability of the drug formulation. For many formulations, stability is governed by the drug product's water content, thus the ... -
Applications of a Biorelevant In Vitro Dissolution Method Using USP Apparatus 4 in Early Phase Formulation Development
(University of Kansas, 2013-08-31)Dissolution plays various roles throughout drug development, including assessment of the lot-to-lot quality of a drug product, guidance for development of new formulations, and assurance of continuing product quality and ... -
Understanding Transformations of Trehalose in the Solid State
(University of Kansas, 2013-05-31)Trehalose has many applications as an excipient in pharmaceutical formulations; however, its use is limited in part because the transformations among the solid forms of trehalose are not yet understood. Form changes that ... -
Correlation of solid-state NMR relaxation times to functional properties such as chemical stability and particle size
(University of Kansas, 2013-05-31)The purpose of the work presented in this dissertation was to investigate the correlation between the particle size of crystalline active pharmaceutical ingredients (APIs) and their solid-state NMR (SSNMR) proton spin-lattice ... -
Instability of Immunoglobulin G (IgG) Monoclonal Antibodies Induced by Redox-Active Metal Ions adn Photo-Irradiation
(University of Kansas, 2012-08-31)Since the approval of the first monoclonal antibody (mAb) drug in 1986, mAbs have developed into a major class of therapeutic agents due to their unique properties. Compared to traditional small molecule drug products, the ... -
Design of Cyclic-ADT Peptides to Improve Drug Delivery to the Brain via Inhibition of E-Cadherin Interactions at the Adherens Junction
(University of Kansas, 2012-08-31)We have developed linear cadherin peptides (i.e., HAV- and ADT peptides) that enhance brain delivery of drug molecules to the central nervous system (CNS). These peptides modulate cadherin interactions in the adherens ... -
Development of lymphatic drug delivery platforms for the treatment of carcinomas
(University of Kansas, 2011-05-31)Many cancers, such as breast cancer, lung cancer, and head and neck cancer, preferentially metastasize via the lymphatic system prior to their systemic invasion. Conventional chemotherapy has limited penetration into the ... -
DEVELOPMENT OF MULTIPLE SAMPLE SOLID-STATE NMR PROBES FOR ANALYSIS OF PHARMACEUTICAL COMPOUNDS AND FORMULATIONS
(University of Kansas, 2011-12-31)Solid-state NMR spectroscopy (ssNMR) is an extremely powerful technique for the analysis of pharmaceutical dosage forms. A major limitation of ssNMR is the number of samples that can be analyzed in a given period of time. ... -
Development and Optimization of Polymeric Carriers for Lymphatic Imaging and Drug Delivery
(University of Kansas, 2011-12-31)Many cancers, including melanoma and breast cancer, metastasize via the lymphatic system, a mono-directional network of vessels and nodes that parallels the circulatory system. Accurate determination of the lymph nodes ... -
Development and Application of a High Throughput Methodology to Characterize and Formulate Protein-Based Therapeutics
(University of Kansas, 2012-12-31)The conformational stability of a protein is a fundamental concern in formulating protein drug products, and development of analytical methods for stability characterization is critical for this purpose. Because of the ... -
STUDIES ON THE CONFORMATIONAL STABILITY, DYNAMICS AND VISCOSITY OF IMMUNOGLOBULINS
(University of Kansas, 2012-12-31)Proteins, such as immunoglobulins, are inherently dynamic molecules with unique biological functions. The intra- and intermolecular interactions that govern the dynamic nature and function of immunoglobulins may also ... -
Investigations into the Synthesis, Identification and Developability of Active Ionic Liquids
(University of Kansas, 2012-12-31)Studied for decades, ionic liquids have largely been used as solvents in the pharmaceutical industry. An active ionic liquid (AIL) contains an active pharmaceutical ingredient (API) as one of the counterions. They have to ... -
Studies on the impact of amine-containing compounds on lysosomes
(University of Kansas, 2011-12-31)Lysosomes accumulate weakly basic amine-containing drugs (i.e., lysosomotropic amines) through an ion trapping-type mechanism and are capable of disrupting lysosomal structure and function. A common finding following ... -
Intracellular Trafficking and Uptake of Hyaluronan-Doxorubicin Conjugates in Vitro
(University of Kansas, 2012-08-31)The purpose of this study was to determine the mechanism of uptake and release of doxorubicin from HA nanoparticle. We used human head and neck squamous cell carcinoma MDA-1986 as a model cell line. MDA-1986 was imaged ... -
Techniques to Improve the Characterization of Protein Particles in Biologic Drug Products
(University of Kansas, 2012-08-31)The characterization of particulate matter, especially protein aggregates, in the sub-visible and visible size range has become an area of focus in the biopharmaceutical industry. This heightened focus is due, in part, to ... -
A Single-step Reaction for Glycosylation of Aminooxy Peptides
(University of Kansas, 2012-08-31)Proteins and peptides have been increasingly used to treat many diseases including autoimmune diseases and cancer. The benefits of using peptides and proteins as drugs for treatment are higher target specificity and ...