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Pharmaceutical Chemistry Dissertations and Theses: Recent submissions
Now showing items 61-80 of 141
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CONSENSUS GII.4 VIRUS LIKE PARTICLES; A VACCINE CANDIDATE BIOPHYSICAL CHARACTERIZATION, STABILIZATION, AND ADJUVANTS BINDING STUDIES
(University of Kansas, 2015-05-31)The World Health Organization (WHO) and the United Nations Children's Fund (UNICEF) estimate globally that 1.9 million children under the age of five years old die annually as consequence of diarrhea. Increasing need for ... -
Induced Supersaturation by Hydroxypropylmethyl Cellulose Under Aqueous Acidic Conditions of a Series of Carboxylic Acid Drugs
(University of Kansas, 2016-05-31)Supersaturation of four structurally related crystalline carboxylic acid drugs (naproxen, indomethacin, ibuprofen, and etodolac) was studied in aqueous acidic conditions at 37ºC in the absence and presence of pre-dissolved ... -
Optimizing the Treatment of Experimental Autoimmune Encephalomyelitis via Pulmonary Delivery of Soluble Antigen Arrays
(University of Kansas, 2016-05-31)Soluble antigen arrays (SAgAs) were used to treat experimental autoimmune encephalomyelitis (EAE), which is a mouse model for multiple sclerosis (MS). SAgAs offer a targeted therapy for MS, which is not present in current ... -
Site-Specific Characterization of Oxidative Carbonylation on Recombinant Monoclonal Antibodies
(University of Kansas, 2016-05-31)In the biotechnology industry, oxidative carbonylation as a post-translational modification of protein pharmaceuticals has not been studied in detail. Using Quality by Design (QbD) principles, understanding the impact of ... -
Noncovalently Associated Cell Penetrating Peptides for Nonviral Gene Delivery
(University of Kansas, 2016-08-31)Gene therapy has become a promising strategy for treatment of numerous diseases such as cancer, hemophilia, and neurodegenerative diseases. Glybera® (alipogene tiparvovec) became the first gene therapy approved in the ... -
Development of theranostics nanomaterials
(University of Kansas, 2014-12-31)Clinical outcomes of conventional anticancer therapies are often compromised due to off-target toxicity and adaptive drug resistance. Moreover, currently there are no imaging modalities that can be utilized for real-time ... -
Aggregation of IgG mAb Biotherapeutics: Sources, Methods of Characterization, and Biological Implications
(University of Kansas, 2014-12-31)One of the predominant concerns with protein therapeutics is their tendency to aggregate at various stages of protein production, purification, filling, transportation, and administration. This occurrence has biological ... -
UNDERSTANDING THE RELATIONSHIPS BETWEEN LOCAL DYNAMICS AND PHYSICAL STABILITY OF IgG1 ANTIBODIES: EFFECTS OF EXCIPIENTS, SALTS AND MUTATIONS
(University of Kansas, 2014-12-31)Immunoglobulins are large multi-domain and multi-functional proteins that are increasingly being developed as biologic drugs to bind to a wide variety of therapeutic targets. The immunoglobulin G1 class of molecules ... -
Fluorogenic Derivatization of Pro-Quinoidal Species: From Biogenic Amines to Protein Bound 3-Nitrotyrosine
(University of Kansas, 2014-12-31)The focuses of this dissertation are an examination and advancement of chemistries for the fluorogenic derivatization of the analysis of proquiniodal species. The term proquinoidal species specifically refers to a group ... -
Using Lysine-Reactive Fluorescent Dye for Surface Characterization of a Monoclonal Antibody
(University of Kansas, 2014-12-31)The last decade has witnessed a rapid growth in the development of protein pharmaceuticals for diagnostic and therapeutic purposes. The biopharmaceutical industry increasingly demands thorough characterization of protein ... -
Predicting the Risk of Crystallization for Suspensions of Amorphous Spray Dried Dispersions from Structural, Thermal and Hydrophilicity Properties
(University of Kansas, 2014-08-31)Suspensions of spray dried amorphous dispersions are a valuable tool for enhancing the exposure of poorly soluble compounds in preclinical animal models. However, limitations in drug supply and time/cost of manufacture in ... -
The Effect of Crystalline and Amorphous Lactose on Mechanical Properties of Roller Compaction Ribbons and Tablets
(University of Kansas, 2014-08-31)Lactose is a widely used excipient in the pharmaceutical industry. It exists as anhydrous, alpha- and beta- monohydrate forms, which can be either crystalline or amorphous. Commercially available lactose comes in various ... -
Determination of Binding Sites of Cadherin Peptides on the EC1 domain of E-cadherin using NMR Spectroscopy
(University of Kansas, 2014-05-31)The objective of this work is to evaluate the binding mechanisms of synthetic cadherin peptides (ADTC7, ADTC9 and cHAVc3) to the EC1 domain of human E-cadherin. The binding sites of these peptides to the EC1 domain were ... -
NanoClusters Enhance Drug Delivery in Mechanical Ventilation
(University of Kansas, 2014-05-31)The overall goal of this thesis was to develop a dry powder delivery system for patients on mechanical ventilation. The studies were divided into two parts: the formulation development and the device design. The pulmonary ... -
Investigating Eutectic Mixtures for Poorly Soluble Compounds
(University of Kansas, 2014-05-31)Abstract Improving the solubility and changing the dissolution rate of the poorly soluble active pharmaceutical ingredients (API's) AMG 517, glipizide, and naproxen through the preparation of eutectic mixtures was investigated. ... -
Formulation Development of Anti-Cancer Drugs
(University of Kansas, 2013-12-31)Formulation issues, including stability, solubility and bioavailability, have been identified as key concerns in anti-cancer drug development. The challenges in pharmaceutical formulation often arise from the different ... -
Toward the Development of an Improved Ricin Vaccine
(University of Kansas, 2013-12-31)To date, there is no approved antidote to treat or prevent the toxic effects of ricin exposure. RiVax, a recombinant ricin A chain subunit vaccine antigen, is one such antidote being developed as a prophylaxis. While it ... -
Studies on the mechanisms and consequences of drug-induced perturbations of lysosomal structure and function
(University of Kansas, 2013-12-31)From a clinical perspective, a drug's pharmacokinetic properties (e.g., the volume of distribution, clearance, and half-life) are vitally important as these parameters are used to establish the proper dosing regimen necessary ... -
Probing Shear Thinning Effects on IgG Molecules at the Air-water Interface via Viscosity and Rheological Measurements
(University of Kansas, 2013-12-31)Shear thinning behavior, observed in shear viscosity tests of IgG therapeutic molecules, may lead to inaccurate reporting of apparent viscosity, depending on the severity of the shear thinning behavior. To determine whether ... -
Binding studies of E-Cadherin peptides to the EC1 domain of E-Cadherin
(University of Kansas, 2013-12-31)The blood brain barrier (BBB) is a key role in delivering medication to the brain; if the drug molecules can overcome this obstacle, many brain diseases (i.e., Alzheimer's, Parkinson's, and brain tumor) can be effectively ...