Pharmaceutical Chemistry Dissertations and Theses
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The synthesis of intermediates for conversion to cortisone analogues
(University of Kansas, 1952-08-31) -
Chemotherapeutic agents in the quinolinol series
(University of Kansas, 1950-05-31) -
Design of Intratumoral Immunostimulant Formulations
(University of Kansas, 2019-12-31)Cancer immunotherapy involves stimulation of the body’s own immune system to fight cancer. Tumors possess myriad suppressive mechanisms that facilitate evasion of the immune system. Immunotherapy aims to stimulate immune ... -
Brain delivery of BDNF and a monoclonal antibody for the treatment of neurodegenerative animal models
(University of Kansas, 2019-12-31)There are a large number of protein-based therapeutics (biologics) that are FDA approved and available on the market for a number of diseases, and the number of biologics being approved every year has tripled in the past ... -
Physicochemical stability and effector function of IgG4-Fc: impact of photo-induced chemical modification and glycosylation
(University of Kansas, 2019-12-31)Immunoglobulin gamma monoclonal antibodies are glycoproteins that have emerged as powerful and promising protein therapeutics. During the process of production, storage and transportation, exposure to ambient light is ... -
Analysis of Spa33 and its Role in T3SS Cytoplasmic Sorting Platform of Shigella
(University of Kansas, 2019-12-31)Enteric infections, particularly those leading to diarrhea, can profoundly disrupt intestinal function and have a major impact on global mortality and morbidity rates.1 Globally, there are 1.7 billion cases of childhood ... -
Preservation of Human T Cell Membrane Integrity after Drying and Rehydration
(University of Kansas, 2019-12-31)The biopharmaceutical industry has reached new frontiers in its ability to produce complex novel modalities for therapeutic application. Novel cell-based therapies offer a promising treatment for cancer by enabling T cells ... -
Method for Simultaneous Quantitation of Free Carrier Protein and Free Polysaccharide in Glycoconjugate Vaccines by High Performance Liquid Chromatography
(University of Kansas, 2019-12-31)Disease caused by bacterial infections affect children and adults worldwide can be potentially life-threatening. Bacterial strains, such as Staphylococcus aureus and Streptococcus pnueumoniae (pneumococcus), express capsular ... -
Development and biophysical characterization of a hyaluronic acid – vitamin E conjugate as a subcutaneous delivery platform
(University of Kansas, 2019-08-31)The inherent properties of protein therapeutics (e.g. high molecular weight, charged, conformationally dependent) has historically limited their administration to parenteral routes which presents new challenges to their ... -
The Application of Machine Learning Algorithms in Understanding the Effect of Core/Shell Technique on Improving Powder Compactability
(University of Kansas, 2019-08-31)The study in this thesis systemically investigated the application of core/shell technique to improve powder compactability. A 28-run Design-of-Experiment (DoE) was conducted to evaluate the effects of the type of core and ... -
Design of Antigen-Specific Immunotherapies Through Modulation of Peripheral Tolerance Pathways
(University of Kansas, 2019-08-31)Current therapies for autoimmune diseases lack specificity for the offending immune cell population resulting in a wide range of side effects and weakening of the immune system. This presents a clear need for antigen-specific ... -
Analytical characterization and formulation development of a trivalent subunit rotavirus vaccine for the developing world
(University of Kansas, 2019-08-31)Although live attenuated, orally delivered rotavirus (RV) vaccines are available globally to provide protection against enteric RV disease, efficacy is substantially lower in low to middle income settings leading to interest ... -
Chemical and Physical Instability of Monoclonal Antibodies Induced by Metal-catalyzed Carbonylation
(University of Kansas, 2019-05-31)In the pharmaceutical industry, recombinant monoclonal antibodies (mAbs) have become a major focus of therapeutic drug development due to their broad applications in many disease areas. During manufacturing and storage of ... -
Utilizing IgG1 Fc As An Immunomodulator
(University of Kansas, 2019-05-31)Antibody-based therapeutics are a rapidly expanding class of biopharmaceuticals. The number of approved antibody-based therapeutics by the FDA and EMA has more than doubled in the last five years, and they are expanding ... -
The Degradation of 4-Morpholinoaniline in Aqueous Solution
(University of Kansas, 2019-05-31)The reactivity of 4-morpholinoaniline with water was examined in aqueous solutions at pH 1 – 4. Two dissociation constant values were identified for 4-morpholinoaniline using spectrophotometric titration: pKa1, which was ... -
Characterization, Stabilization and Formulation Design of IgG and Secretory IgA Monoclonal Antibody Candidates during Storage and Administration
(University of Kansas, 2019-05-31)ABSTRACT Monoclonal antibodies (mAbs) have become a class of therapeutic protein-based drugs of high importance for treating numerous human diseases. As a complex, delicate three dimensional molecule, a mAb can be sensitive ... -
Targeted Proteomics for Exosome Analysis and Its Application to Develop Blood Markers of Liver Drug-Metabolizing Enzymes
(University of Kansas, 2019-05-31)Two main routes of drug elimination include renal excretion via the kidney and metabolic degradation via metabolizing enzymes (DMEs) in the liver, followed by renal excretion or biliary elimination of the now more polar ... -
Strategies to improve the immunogenicity of subunit vaccine candidates
(University of Kansas, 2018-12-31)Subunit vaccines contain highly defined macromolecular components of a pathogen that are capable of eliciting protective immunity. They possess several advantages over other vaccine types (e.g. live attenuated and inactivated) ... -
Understanding the metabolic processes and degradation of therapeutic proteins after subcutaneous administration
(University of Kansas, 2018-12-31)Subcutaneous (SC) route is important for administration of various therapeutic proteins (TPs) like monoclonal antibodies (mAbs), human growth hormone (hGH), insulin, and recombinant subunit vaccines. The SC route has ... -
Impact of Fill-Finish Process on Protein Formulation in the Absence of Stabilizing Agents
(University of Kansas, 2018-12-31)Optimization of the fill-finish process for a biotherapeutic is imperative for the highest quality drug product. Chemical and physical degradation must be fully characterized as an enzyme progresses towards commercialization ...