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Pharmaceutical Chemistry Dissertations and Theses: Recent submissions
Now showing items 101-120 of 141
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INVESTIGATING PHARMACEUTICAL CO-CRYSTALS AS A MEANS TO IMPROVE THE SOLUBILITY OF A DRUG
(University of Kansas, 2012-05-31)Recently co-crystals have emerged as a potential approach to improve the solubility, dissolution, and bioavailability of active pharmaceutical ingredients (API). Often co-crystal formation is studied in the development ... -
INVESTIGATION OF SITE-SPECIFIC CHANGES WITHIN THE N-TERMINAL DOMAIN OF CALMODULIN AND THE RELATIONSHIP TO STRUCTURAL AND THERMAL STABILITY
(University of Kansas, 2011-08-31)The goal of this dissertation was to develop a method to assess how solution conditions affect a protein's stability, and a well-characterized model protein, was used to accomplish this objective. Generally, stabilizing ... -
Comparisons of Two Different Analytical Methodologies for the Characterization of Sub-Visible Particles in Therapeutic Protein Formulations
(University of Kansas, 2011-12-31)The US and EU pharmacopeias require sub-visible particle (SbVP) testing of parenteral drug products by either light obscuration (LO) or light microscopy. According to the USP/EP, the LO method requires the use of four ... -
Development of Peptides to Target Antigen Presenting Cells for Controlling the Immune Response in Experimental Autoimmune Encephalomyelitis
(University of Kansas, 2011-12-31)Experimental autoimmune encephalomyelitis (EAE) is an animal model for the human disease multiple sclerosis (MS). In EAE and MS, the immune system recognizes proteins of the myelin sheath as antigenic, and an inflammatory ... -
Utilizing Antigenic Peptide and Adhesion Molecule Conjugates to Suppress Autoimmune Disease in Animal Models
(University of Kansas, 2011-12-31)Peptides and proteins have been used as carriers to target and deliver molecules to sites of action. Conjugating a drug to a macromolecule offers the unique advantage of being able to target drug to a specific cell surface ... -
Reactivity of the Quinone Methide of Butylated hydroxytoluene in Solution
(University of Kansas, 2011-08-31)BHT is a common antioxidant in pharmaceutical formulations and when oxidized it forms a quinone methide (QM). QM is a highly reactive electrophilic species which can undergo nucleophilic addition. This research investigated ... -
Synthesis and Characterization of Lipid-Polymer Hybrid Nanoparticles for Combinatorial Drug Delivery
(University of Kansas, 2011-08-31)Abstract Overcoming obstacles like multidrug resistance, short circulation half-life, and nonspecific systemic distribution is an ongoing challenge in cancer therapy. One application to address these concerns is to engineer ... -
Soluble Antigen Arrays utilize molecular and physical features to suppress Experimental Autoimmune Encephalomyelitis
(University of Kansas, 2011-08-31)Blockade of immune cell adhesion during antigen recognition may suppress the inflammatory immune response in autoimmune diseases. Employing a novel N-oxime chemistry, Soluble Antigen Arrays (SAgAs) were synthesized to ... -
Effect of pH and light on aggregation and conformation of an IgG1 mAb
(University of Kansas, 2011-08-31)During the purification process, monoclonal antibodies may be exposed to parts of UV-C (200 to 290 nm), UV-B (290 to 320 nm) and visible light (400 to 760 nm) under a variety of buffer and pH conditions. Together, these ... -
Polyelectrolyte-based Nanoparticles for Gene and Protein Delivery
(University of Kansas, 2011-05-31)Polyelectrolytes have emerged as a versatile, simple and promising tool to deliver therapeutic payloads. Their ability to form complexes with oppositely charged polymers or biomacromolecules has led to various applications ... -
Nonviral Vectors for Gene Delivery
(University of Kansas, 2011-04-26)The development of nonviral vectors for safe and efficient gene delivery has been gaining considerable attention recently. An ideal nonviral vector must protect the gene against degradation by nuclease in the extracellular ... -
Characterization of Amorphous Solid Dispersions of AMG 517 in HPMC-AS and Crystallization using Isothermal Microcalorimetry
(University of Kansas, 2011-04-26)Purpose. Recently there has been increasing interest in the development of amorphous materials, particularly on developing low solubility drugs as amorphous solid dispersions (ASDs). Understanding the crystallization rate ... -
Solid-State Physical Form Detection and Quantitation of Pharmaceuticals in Formulations
(University of Kansas, 2011-03-25)The majority of pharmaceutical dosage forms are marketed as solids, and the active pharmaceutical ingredient (API) can exist in various physical forms. These physical forms can be either crystalline or amorphous, and will ... -
The Development of Analytical Methods for Investigations of Dynorphin A 1-17 Metabolism in the Central Nervous System and Peripheral Tissues and Transport at the Blood Brain Barrier
(University of Kansas, 2011-02-15)Dynorphin A 1-17 (Dyn A 1-17) is an endogenous neuropeptide that acts preferentially at the kappa opioid receptor. Elevated concentrations of Dyn A 1-17 have demonstrated neurotoxicity via a non-opioid mechanism, potentially ... -
Effect of pH, sucrose and mannitol on structure and long-term stability of a model IgG1 antibody upon freeze-drying
(University of Kansas, 2011-01-31)Purpose: The purpose of this study is to investigate the effect of pH and potential stabilizers on structure and long-term stability of an IgG1 monoclonal antibody in the solid state after freeze-drying. The inter-relationships ... -
Multidrug resistance-associated protein (MRP) isoforms and the breast cancer resistance protein (BCRP) mediate sulfate conjugate efflux out of BeWo cells
(Elsevier, 2010)The breast cancer resistance protein (BCRP) and the multidrug resistance-associated proteins (MRPs) have the ability to eliminate sulfate conjugates but it is not known if this constitutes one of their roles in the placenta. ... -
FORMATION OF A PHYSICALLY STABLE AMORPHOUS DRUG COMPLEX
(University of Kansas, 2010-12-16)ABSTRACT In this paper we explore the use of Neusilin, an inorganic magnesium aluminometasilicate, to stabilize the amorphous form of an acidic drug a neutral drug and two basic drugs. Both cryomilling and ball milling of ... -
Targeting of nanoparticles to cell adhesion molecules for potential immune therapy
(University of Kansas, 2010-12-10)Cell adhesion molecules including leukocyte function associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) play an important role in regulating inflammatory responses. For circulating leukocytes to ... -
Bioanalysis of Pteroyl Derivatives in Various Aspects of Human Health
(University of Kansas, 2010-11-29)This dissertation describes the development of bioanalytical strategies for a group of experimental and known therapeutic agents and chemically related essential substances. The array of analytes include the antifolate ... -
Solid-State NMR Analysis of Excipients and Drug-Excipient Interactions in the Amorphous State
(University of Kansas, 2010-08-27)Solid-state NMR (SSNMR) experiments were used to investigate numerous aspects of pharmaceutically relevant amorphous materials, such as structure, molecular weight, water content, interactions with other molecules, and ...