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Pharmaceutical Chemistry Dissertations and Theses: Recent submissions
Now showing items 121-140 of 141
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INVESTIGATING THE EFFECT OF ENANTIOMERIC RATIO AND PREPARATION METHOD ON CRYSTALLINE FORMS OF PROLINE USING SOLID-STATE NMR SPECTROSCOPY
(University of Kansas, 2010-08-26)Chiral molecules are prevalent among currently marketed pharmaceutical products, many of which are solid formulations. The solid-state form of a drug can have a dramatic effect on its solubility, dissolution rate (hence ... -
IN VITRO AND IN VIVO EVALUATION OF NOVEL I-DOMAIN CONJUGATES FOR DRUG TARGETING TO IMMUNE CELLS AND SUPPRESSION OF EAE IN MICE
(University of Kansas, 2010-06-23)The long-term objective of this project is to utilize the I-domain of leukocyte function associated antigen-1 (LFA-1) to target antigenic peptides and drugs to intercellular adhesion molecule-1 (ICAM-1) expressed on the ... -
The Application of Empirical Phase Diagrams to the Biophysical Characterization and Stabilization of Viral Vaccine Candidates
(University of Kansas, 2010-04-20)This dissertation describes the application of a composite biophysical approach to the characterization and stabilization of viruses and virus-like particles for vaccine purposes. Spectroscopic, calorimetric, and ... -
COCRYSTALLIZATION TO IMPROVE THE DISSOLUTION AND PHARMACOKINETICS OF A POORLY SOLUBLE DRUG
(University of Kansas, 2010-04-12)Improving the dissolution and pharmacokinetics of the poorly soluble active pharmaceutical ingredient, AMG 517, through cocrystallization was investigated. Correlations between the in vitro powder and intrinsic dissolution ... -
Methods for Increasing Sensitivity and Throughput of Solid-State NMR Spectroscopy of Pharmaceutical Solids
(University of Kansas, 2010-01-22)Solid-state nuclear magnetic resonance (SSNMR) spectroscopy has been demonstrated to be a powerful technique for investigating solid dosage formulations. SSNMR has the ability to determine physical form, molecular structure, ... -
Development of Analytical Methodology for Neurochemical Investigations
(University of Kansas, 2010-01-25)David J. Fischer Department of Pharmaceutical Chemistry University of Kansas Neurochemical Applications of Microchip Electrophoresis The development of sensitive and selective analytical tools has facilitated the investigation ... -
Formulation and Development of Recombinant Protein Vaccines
(University of Kansas, 2009-04-02)Recombinant protein vaccines are fast becoming the focus of the vaccine industry due to their increased safety. Here we examine the development of several recombinant protein vaccines and the challenges involved. Once an ... -
ROLES OF SULFOTRANSFERASE ENZYMES IN TRANS-PLACENTAL DISPOSITION
(University of Kansas, 2009-01-28)The trophoblast cell layer constitutes the rate-determining barrier for trans-placental transfer. Several isoforms of the sulfotransferase enzymes are functional in placenta but there is only limited information available ... -
Development of online microdialysis-microchip system for in vivo monitoring
(University of Kansas, 2009-08-31)Microdialysis is a sampling technique that can be employed to monitor biological events in vivo and chemical reactions in vitro. When it is coupled to an analytical system, microdialysis can provide near real time information ... -
Understanding Structural Stability of Pharmaceutically Relevant Macromolecular Complexes: A Biophysical and Biochemical Approach
(University of Kansas, 2009-08-10)Macromolecules, due to their large size and complexity are prone to a variety of physical and chemical degradations. Development of stable formulations that retain the macromolecule's stability and activity over its ... -
Age-Dependent Changes in Protein Phosphorylation: Differential Studies in Rat Tissue
(University of Kansas, 2009-12-16)Protein phosphorylation is a reversible process that is involved in cellular growth, division and signaling. The mechanisms for protein phosphorylation can be significantly altered during the aging process. These alterations ... -
Using High-Resolution NMR to Examine the Components that Contribute to the Activity and Stability of Phosphatase of Regenerating Liver (PRL-1) and Their Dependence on the Redox State of Cysteine Residues
(University of Kansas, 2009-12-15)Phosphatase of regenerating liver (PRL-1) has gained attention as an important therapeutic target because of its involvement in cancer and metastasis, where it promotes proliferation and cell motility. The protein is found ... -
CREATING A MULTIVALENT SUBUNIT VACCINE USING TYPE III SECRETION SYSTEM TIP PROTEINS AS ANTIGENS
(University of Kansas, 2009-07-06)Many gram-negative bacterial pathogens employ type III secretion systems (TTSS) to transport effector proteins into eukaryotic host cell membranes and cytoplasms to subvert normal cellular functions. TTSSs contain a basal ... -
The Niemann-Pick C1 Protein Functions in Regulating Lysosome Amine Content
(University of Kansas, 2008-01-01)Mutations in the lysosome membrane protein Niemann-Pick C1 (NPC1) are known to cause a generalized block in retrograde vesicle-mediated transport from the lysosome, resulting in the hyper-accumulation of multiple lysosomal ... -
Synthesis and Physiochemical Characterization of Sulfenamide Prodrugs of Antimicrobial Oxazolidinones
(University of Kansas, 2008-10-24)The synthesis, physicochemical characterization and evaluation of sulfenamide derivatives of antimicrobial oxazolidinones as prodrugs are described in this dissertation. Synthesis of sulfenamide derivatives described in ... -
A Proteomic Study of Protein Tyrosine Nitration
(University of Kansas, 2008-08-28)Protein post-translational modifications are of great interest due to their effects on protein structure and function. Our interest lays in the nitration of tyrosine residues by powerful oxidants such as peroxynitrite ... -
Targeted Drug Delivery To Leukocytes with ICAM-1 Derived Peptides
(University of Kansas, 2008-07-15)Intercellular adhesion molecule-1 (ICAM-1) derived cyclic peptide cIBR [cyclo(1,12)PenPRGGSVLVTGC] showed high affinity for leukocyte function associated antigen-1 (LFA-1) receptor and was internalized into the MOLT-3 ... -
Chemical and Physical Characterization of Therapeutic Proteins in Solution and Amorphous Solids
(University of Kansas, 2008-06-16)The chemical and physical stability of proteins in solution and solids was addressed in this dissertation. Protein-excipient interactions in lyophilized solids were studied by hydrogen/deuterium exchange with mass spectrometry ... -
Improvement of the chemical and physical stability of the EC1 domain of E-cadherin by blocking its disulfide-mediated dimerization
(University of Kansas, 2008-01-30)The EC1 protein has an important role in the E-cadherin mediated cell-cell adhesion in epithelial and endothelial tissues. It may be used as modulator of cellular adhesion to improve paracellular delivery of macromolecules. ... -
Improving the Biopharmaceutical Properties of Cyclic Opioid Peptide Prodrugs
(University of Kansas, 2008-05-05)In an attempt to improve the "drugability" of opioid peptides, cyclic prodrugs of the opioid peptide DADLE (H-Tyr-D-Ala-Gly-Phe-D-Leu-OH) were developed using a coumarinic acid linker (CA). CA-DADLE was metabolically ...