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    Mechanisms of Cutaneous Wound Healing are Mediated via Peripheral Neuropeptide Activity

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    umi-ku-2638_1.pdf (1.182Mb)
    Issue Date
    2008-07-16
    Author
    Rook, Jerri Michelle
    Publisher
    University of Kansas
    Format
    171 pages
    Type
    Dissertation
    Degree Level
    PH.D.
    Discipline
    Pharmacology, Toxicology & Therapeutics
    Rights
    This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
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    Abstract
    Topically applied morphine is routinely used to alleviate pain in cutaneous wounds such as burns and pressure sores, yet evidence suggests the topical administration of exogenous opioid drugs may impair wound closure. This dissertation research was designed to test the hypothesis that topical morphine application delays cutaneous wound healing via mechanisms dependent upon peripheral neuropeptide activity. Results demonstrate that topical morphine application delays cutaneous wound closure rates. The delay occurs in a concentration-dependent manner (consistent with opioid-receptor mediated effects), is mimicked by NK-1 and NK-2 receptor antagonists, and can be reversed by the exogenous application of either substance P or neurokinin A. The results indicate that morphine acts presynaptically, delaying wound closure by activating opioid receptors located on primary afferent nerve terminals and subsequently inhibiting the antidromic release of neuropeptides into the wound. The temporal pattern of the effects of topical morphine treatment can be attributed to alterations in the initiation and duration of essential, early processes during wound healing. The delay in closure evoked by topical morphine not only leaves the cutaneous wound open longer, increasing the risk of infection, but also results in long-term architectural deficits, compromising the integrity of the healed skin. Furthermore, dysregulation of neurokinin receptor-expressing cells essential for normal wound healing emerges as a mechanism capable of significantly disrupting the dynamic processes involved in wound healing.
    URI
    http://hdl.handle.net/1808/4232
    Collections
    • Dissertations [4475]
    • Pharmacy Dissertations and Theses [118]

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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