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    AURORA KINASES IN SOLELY ESTROGEN-INDUCED ONCOGENESIS: RELATION TO CENTROSOME AMPLIFICATION AND CHROMOSOMAL INSTABILITY

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    Issue Date
    2008-06-02
    Author
    Hontz, Adrianne Elizabeth
    Publisher
    University of Kansas
    Format
    180 pages
    Type
    Dissertation
    Degree Level
    PH.D.
    Discipline
    Pharmacology, Toxicology & Therapeutics
    Rights
    This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
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    Abstract
    Estrogens play a crucial role in the causation and development of sporadic breast cancer, which accounts for ~ 90 - 95% of all breast cancer cases. To understand the molecular and cellular events involved in solely estrogen-induced oncogenesis, we studied the role of mitotic kinases, Aurora A and B, and the MDM2-p53wt pathway in estrogen-elicited oncogenesis, using two animal tumor models, the estrogen-induced tumors of the kidney in male Syrian hamsters, and the mammary gland in female ACI rats. Evidence is presented indicating that both Aurora kinase and MDM2 over-expression are under estrogen control in both tumor models studied. Our data further show that estrogens, interacting with the estrogen receptor α, elicit persistent Aurora A kinase over expression that may affect abnormal centrosome duplication, and together with the loss of p53wt activity by the over expression of MDM2 lead to estrogen-induced oncogenesis.
    URI
    http://hdl.handle.net/1808/4234
    Collections
    • Dissertations [4473]
    • Pharmacy Dissertations and Theses [118]

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    785-864-8983
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    785-864-8983

    KU Libraries
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    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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