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    A REVIEW OF NUCLEAR RECEPTOR GENE ACTIVATION THROUGH COFACTOR PROTEIN INTERACTIONS

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    Issue Date
    2008-07-07
    Author
    Baker, Robert L.
    Publisher
    University of Kansas
    Format
    40 pages
    Type
    Thesis
    Degree Level
    M.A.
    Discipline
    Pharmacology & Toxicology
    Rights
    This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
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    Abstract
    Humans are faced with a vast number of pathological conditions. Some the most prevalent and deadly disease states include cancer, obesity, and diabetes. A large amount of scientific research and development has gone into determining the underlying cause of these pathologies. Certain aspects of the aforementioned diseases have been linked to the aberrant expression and activity of selected gene-expression-programs. Gene expression is regulated by proteins known as transcription factors. One of the largest transcription factor families is the nuclear receptor (NR) superfamily. The ability of NRs to drive gene activation is directed by specific interacting proteins called cofactors. This review will highlight new discoveries regarding the mechanistic role of NRs and their associated protein cofactors in regulating gene activation and in the progression of cancer, diabetes, and obesity.
    URI
    http://hdl.handle.net/1808/4246
    Collections
    • Pharmacy Dissertations and Theses [118]
    • Theses [3828]

    Items in KU ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.


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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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