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Chemistry: Recent submissions
Now showing items 121-140 of 964
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Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma
(Springer Nature, 2019-03-22)A systematic study of the stability of a set of cephalosporins in mouse plasma reveals that cephalosporins lacking an acidic moiety at C-2 may be vulnerable to β-lactam cleavage in mouse plasma. -
Modulation of Pro-Oxidant and Pro-Inflammatory Activities of M1 Macrophages by the Natural Dipeptide Carnosine
(MDPI, 2020-01-25)Carnosine is a natural endogenous dipeptide widely distributed in mammalian tissues, existing at particularly high concentrations in the muscles and brain and possesses well-characterized antioxidant and anti-inflammatory ... -
Hydrogen-Bonding Linkers Yield a Large-Pore, Non-Catenated, Metal-Organic Framework with pcu Topology
(MDPI, 2020-02-06)Pillared paddle-wheel-based metal-organic framework (MOF) materials are an attractive target as they offer a reliable method for constructing well-defined, multifunctional materials. A drawback of these materials, which ... -
Microfluidic Device for On-Chip Immunophenotyping and Cytogenetic Analysis of Rare Biological Cells
(MDPI, 2020-02-24)The role of circulating plasma cells (CPCs) and circulating leukemic cells (CLCs) as biomarkers for several blood cancers, such as multiple myeloma and leukemia, respectively, have recently been reported. These markers can ... -
Facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea
(Beilstein-Institut, 2019-11-27)A highly divergent synthesis of regioisomeric thiohydantoins and pseudothiohydantoins spiro-fused to a pharmacologically valuable pyrrole-2-one fragment involving the reaction of [e]-fused 1H-pyrrole-2,3-diones with thioureas ... -
Mechanisms of Condensed Phase Reactions: The Role of Structure, Dynamics, and Environment in Photoisomerization and Photodissociation
(University of Kansas, 2019-08-31)Light-activated chemistry begins with the excitation of a ground-state molecule to a higher-lying excited state. Once in the excited state, the nuclei in the molecule respond by trying to minimize the energy of the system. ... -
Quantitative Methods to Determine Brain Deposition of Peptides and Proteins after Delivery across the Blood-Brain Barrier
(University of Kansas, 2019-08-31)It is very challenging to develop peptide and protein drugs for treatment of brain diseases because it is difficult to deliver them to the brain due to the presence of the blood-brain barrier (BBB). Therefore, there is an ... -
Analyzing Extracellular Vesicles as Potential Biomarkers of Stroke Using Polymer Microfluidic Devices
(University of Kansas, 2019-08-31)A major drawback of currently available stroke diagnosis methods, such as computed tomography (CT) and magnetic resonance (MRI), is that they cannot provide timely diagnosis within the narrow therapeutic time window of 4.5 ... -
Development and Application of Computational Tools to Study Optical Rotation of Chiral Molecules in Isotropic Media
(University of Kansas, 2019-12-31)The study of optically active molecules has been continuous for over two centuries, due to the role chiral molecules play as both the building blocks of life, and therefore their importance in developing pharmaceuticals. ... -
Surface Immobilization and Electrochemical Studies of Molecular Lanthanide and Actinide Complexes
(University of Kansas, 2019-05-31)Due to their unique properties and emerging applications in materials, the chemistry of the lanthanides and actinides has become a thriving area of research. While much work has been done to probe the electronic, magnetic, ... -
Theoretical and Experimental Development of Bipolar Based Fluorescence Detection for Microchip Electrophoresis
(University of Kansas, 2019-05-31)Abstract Methods for the separation and detection of reactive oxygen and nitrogen species (RNOS) at the cellular level can be useful tools for the study of the biochemical mechanisms of neurodegenerative diseases. Microchip ... -
Analysis of Glycopeptides by HPLC MS and Detection of Leukemic Cells by Microfluidics using Time Delayed Integration Spectral Flow Cytometry
(University of Kansas, 2019-05-31)Protein glycosylation drives many biological processes and serves as marker for disease; therefore, the development of tools to study glycosylation is an essential and growing area of research. Mass spectrometry can be ... -
Materials for Molecular Electronics Devices: Anchoring Azulene Derivatives to A Gold Surface via Molecular Self-Assembly
(University of Kansas, 2019-05-31)The use of molecular electronics to build nano-scale devices is potentially applicable to the development of electronic components, such as wires, switches, or diodes. The work described herein involves the self-assembly ... -
Metal-Templated Assembly of Heterocyclic Rings via Nucleophilic Cyclization of Cyclopropenes
(University of Kansas, 2019-05-31)This thesis is focused on the development and application of methods for the intramolecular nucleophilic addition of tethered nucleophiles to cyclopropenes. Addition of carbon-, nitrogen, and oxygen-nucleophiles was ... -
Extracellular Processing of Lysyl Oxidase-like 2 and Its Effect on Amine Oxidase Activity
(American Chemical Society, 2018-11-30)Overexpression of lysyl oxidase-like 2 (LOXL2) is associated with several hepatic and vascular fibrotic diseases and tumor progression in some aggressive cancers. Secreted LOXL2 promotes extracellular matrix cross-linking ... -
Tocopherol Emulsions as Functional Autoantigen Delivery Vehicles Evoke Therapeutic Efficacy in Experimental Autoimmune Encephalomyelitis
(American Chemical Society, 2019-01-07)Contemporary approaches to treating autoimmune diseases like multiple sclerosis broadly modulate the immune system and leave patients susceptible to severe adverse effects. Antigen-specific immunotherapies (ASIT) offer a ... -
Metal-Templated Assembly of Cyclopropane-Fused Diazepanones and Diazecanones via exo-trig Nucleophilic Cyclization of Cyclopropenes with Tethered Carbamates
(American Chemical Society, 2018-10-24)A strain-release-driven, cation-templated nucleophilic 7- and 8-exo-trig-cyclization of tethered Boc-protected amines to cyclopropenes is described. The featured reaction proceeds in diastereo- and regioselective fashion ... -
Continuous monitoring of adenosine and its metabolites using microdialysis coupled to microchip electrophoresis with amperometric detection
(Royal Society of Chemistry, 2018-05-09)Rapid monitoring of concentration changes of neurotransmitters and energy metabolites is important for understanding the biochemistry of neurological disease as well as for developing therapeutic options. This paper describes ...